2500 ug cbd oil for pain

Should You Give Your Kid CBD?

More Americans are using the hemp (or marijuana) extract on their kids, but experts aren’t sold on its efficacy.

Send any friend a story

As a subscriber, you have 10 gift articles to give each month. Anyone can read what you share.

Give this article

Priscilla Batista is stuck at home in Charlotte, N.C., with a highly emotional 4-year-old.“Every toddler obviously is emotional, but she’s a pretty constant, volatile child,” she said. “It doesn’t allow her to focus. She’s just struggling.” Batista doesn’t yet have an official diagnosis for her daughter, but, suspecting an attention deficit disorder, she has turned to CBD (cannabidiol) for help.

CBD is one of the more well-known components of cannabis, along with THC (tetrahydrocannabinol). Both chemicals affect the brain, but while THC makes users feel high, CBD doesn’t, though it does make some users feel more relaxed. CBD products have become hugely popular around the world, from oils that can be eaten or rubbed on skin, to soaps, gummy candies and even pet treats.

A 2019 Gallup poll found 14 percent of more than 2,500 Americans surveyed use CBD products, mostly for pain, anxiety and sleep problems. Statistics for kids are much harder to come by, but there are Facebook groups with thousands of followers where parents discuss giving CBD to their kids for conditions including the autism spectrum and attention deficit hyperactivity disorder. In April, a cannabis-focused magazine published a survey of more than 500 parents and found that 40 percent had given CBD products to their children for behaviors related to the autism spectrum.

Very little controlled research has been done with CBD and kids. There is only one approved drug based on CBD for any age group, and that’s for rare kinds of epilepsy in children. There are promising hints — but little proof thus far — that the compound might work on some other conditions in children too, including other kinds of seizures, autism and anxiety.

“When you’re desperate, you want options,” said John Mitchell, clinician at Duke ADHD Clinic in Durham, N.C. “I’m a parent myself. I get it.” But, he cautioned, for now the enthusiasm is running ahead of the science. “I’m very hesitant to say anything promising about it. It’s an open question.”

The medical community considers pure CBD relatively safe: The World Health Organization, for example, has said there’s no evidence of anyone abusing CBD recreationally, or of any public health problems. But there are still some risks, especially for kids.

Last year, the Food and Drug Administration wrote that CBD has the potential to cause liver injury (in users of any age), and suggested it might affect the developing brains of children. No one knows the long-term effects of giving CBD to kids, said Arno Hazekamp, Ph.D., a pharmaceutical researcher and cannabis consultant in the Netherlands. “Those kids are still kids,” he said. Researchers will have to wait until they are older to assess long-term effects. Also, since most CBD products aren’t regulated, he added, they can be tainted with dangerous additives.

Hints of help

The only drug containing CBD that has been approved for adults or children is Epidiolex, which is currently the only known treatment for two rare and devastating forms of childhood epilepsy: Dravet syndrome and Lennox-Gastaut syndrome. Epidiolex, approved in 2018, was developed after the high-profile case of Charlotte Figi, whose desperate mother used CBD to dramatically control her debilitating seizures.

The way that CBD acts on the brain makes it a good candidate for controlling seizures caused by other conditions too. The Epilepsy Foundation said that early evidence from animal studies, anecdotal reports and small clinical trials suggest that CBD could potentially help with seizures. Dozens of trials are underway to test if, why and how CBD might work for kids and adults suffering from seizures of various kinds.

There are also hints CBD might work for some autistic kids. Dr. Gal Meiri, M.D., clinical director of the National Autism Research Center of Israel at Ben Gurion University of the Negev, has studied CBD oils and autism. In a study that Meiri co-authored in 2019, 155 autistic kids aged 18 years and younger tried CBD oil for at least six months. More than 80 percent of the parents reported significant or moderate improvement in their kids. “Some of the parents reported benefits not just with seizures but also behaviors, like self-harm,” he noted.

See also  How long does cbd oil effects last for dogs

Most such studies are based on parents’ perceptions, rather than measured changes in comparison to placebo groups. The placebo effect can be strong, since parents typically want to see improvements. A placebo-controlled trial of CBD for autistic children has been completed at the Shaare Zedek Medical Center in Israel, but the results aren’t yet published. Another is underway at the University of California, San Diego.

“I’m trying to be very cautious about it,” said Meiri with regards to CBD and autism. “We still don’t have enough research about safety and efficacy.”

Similarly, many parents are trying CBD products for children with A.D.H.D., for which there are no reported controlled trials with kids. One small trial on 30 adults with a mouth spray containing both CBD and THC had inconclusive results.

With no scientific proof that CBD works and is safe for children, Mitchell said stimulant-based medications like Adderall are a better option than CBD. “We know much more about one than the other, so the choice is simple,” he said. But he understands why a parent might consider CBD as an alternative, he said, given that it is typically seen as a gentle drug with few side effects.

That matches Batista’s experience. “My daughter has a beautiful personality; she’s sweet, she’s spunky. I don’t want to medicate her with something that’s going to turn her into a zombie,” she said, referring to parent complaints that some stimulant-based drugs can make their kids seem spacey.

“I don’t want her to fall behind,” she said. Batista has seen other kids with A.D.H.D. struggle academically. “It can really swallow a kid whole; then you have a failure to launch.”

Mitchell added there are signs CBD might help with anxiety: a symptom that sometimes accompanies autism and A.D.H.D. In a 2018 study of CBD for kids with autism, for example, anxiety improved in more than a third of the 60 patients.

Surprisingly, there’s not much evidence that CBD helps with sleep — despite its reputation for causing drowsiness in recreational users. “Something can make you sleepy and have no effect on your sleep quality,” said Hazekamp.

No silver bullets

Even if CBD is someday approved for use against other kinds of seizures, autism or A.D.H.D., it is unlikely to work for everyone.

Kelly Cervantes, a mother and health activist in Chicago, gave CBD to her daughter Adelaide, who suffered from an unidentified neurodegenerative condition with severe infantile spasms. “We were desperate, and we wanted to try anything we could,” said Cervantes. That was when her daughter was about a year and a half old, and before Epidiolex, so she says she got the product online rather than though her doctor. Sadly, Adelaide’s symptoms got worse. “It entirely depends on the child. There is no one pill, one oil, one treatment that is going to cure everyone,” she said.

In addition, Adelaide’s doctors began to see signs of liver failure. Cervantes took her off the CBD. She said CBD, “does not come without side effects, which I think is a major misconception about it.” In trials of Epidiolex, a moderate dose caused side effects in at least 10 percent of the children, including elevated liver enzymes, decreased appetite, diarrhea, fatigue, sleep problems and malaise.

Furthermore, it’s impossible to know what’s in a CBD product without independent testing. One of Hazekamp’s studies in the Netherlands analyzed 46 cannabis oils made by patients or sold online. Only 21 products even advertised the ingredient concentrations and many of those were wildly wrong. Seven didn’t contain any cannabinoids at all. One of them had more than 50 percent more THC in it than the product claimed.

“There can be pesticides, heavy metals and microbes in the plants,” said Hazekamp. It isn’t clear if those are making it into CBD oils, he said.

It’s impossible to overdose on pure CBD, but synthetic knock-offs can be poisonous. In 2019, the American Association of Poison Control Centers put out an alert noting “growing concern” about CBD products, with national calls about CBD rocketing from just over 100 in 2017 to more than 1,500 last year.

See also  Cbd oil side effects for dpgs

“The labels aren’t always right,” said Hazekamp. “If you try it, make sure it is what you think it is.”

Talk to your doctor

When Cervantes tried CBD, she bought it online from what she believed to be a reputable company, but she can’t be sure what was in it. It would help parents of suffering children, she said, if CBD products were more regulated and parents felt they could talk to their doctors about it, rather than worrying about its association with marijuana.

“I had a patient start taking CBD and I only found out a month in,” said Mitchell. “Parents may assume that a doctor will respond in a negative way.” It’s a doctor’s responsibility, he said, to be open to discussing options. “If you shut a patient down, it doesn’t mean you won the argument, it means they’re not going to talk about it.”

Batista said her daughter’s doctors told her to be careful with CBD and didn’t recommend it.

Still, she’s been using it for several months, getting it from a company that advertises independent testing to confirm their product’s contents, and starting with a low dose. She said she can’t tell if it’s doing anything, but holds out hope that a gentle drug with few side effects will be effective for her little girl. “I want to think that it’s helping.”

Concentration Level

One of the variables to take into consideration when evaluating CBD products is potency.

CBD potency specifically refers to how strong it is. If a CBD extract is rated at 300mg, it’s going to be about half as strong (potent) as the same amount of a CBD extract rated at 600mg CBD. These potencies also rely on the actual size of the bottle! The total CBD listed in mg refers to the dose contained IN THE ENTIRE BOTTLE. If you have a smaller bottle, the potency will increase, so 300 mg in a 15 mL bottle will be twice as potent as a 300 mg oil in a 30 mL bottle.

The majority of CBD companies sell oil tinctures in three different potencies:

• 300 mg
• 600 mg
• 1000 mg

Each of these potencies can come in a 15, 30, 50, or 60mL bottle. These are the most common, but there are also more potent 2000 mg and 4000 mg CBD options available too.

The most important thing to remember when you buy CBD oil is to keep in mind that the bottle size matters. There’s a simple calculation you can make to determine the strength of a CBD oil. It goes like this:

[AMOUNT OF CBD IN MG] ÷ [BOTTLE SIZE IN ML] = STRENGTH IN MG/ML

• Anything below 5 mg/mL (10%) is considered low strength
• Anything between 15 and 30 mg/mL (15-30%) is medium strength
• Anything between 30 and 60 (30-60%) is high strength
• Anything else (60+%) is considered ultra-high strength or classified as a concentrate

CBD oil, like most products, can be watered down. Although concentrations of CBD vary across a wide range, quality products will provide between 250mg and 1,000mg per fluid ounce. An effective dosage can range from as little as a few milligrams of CBD oil to a full gram or more, depending on several individual factors and the condition you are interested in treating.

Always start with a small dose, especially if you have little or no experience with cannabis. Less is often more with regard to cannabis therapy; the compounds in CBD oil have biphasic properties, meaning that low and high doses often produce opposite effects. Small doses of CBD oil tend to stimulate; large doses sedate. CBD has no known adverse side effects, but an excessive amount of CBD is likely to be less effective than a moderate dose.
Though there are seemingly endless different CBD manufacturers to choose from, most will offer products in at least two or three different potencies or concentrations. Starting with the lowest potency lets you adequately gauge how much CBD is needed to relieve your specific condition. You can gradually increase the dose to see how that works for you, simultaneously reducing the likelihood of developing a tolerance to the product.

Low-potency CBD oil (300 mg):

Relatively low-potency oil (300 mg) is likely to be a good option for people who may be sensitive to CBD, and some individuals’ endocannabinoid systems are more active than others, so naturally they won’t need as much CBD as others. Many people use a 300 mg oil for things like mild to moderate anxiety, or minor aches & pains. A single serving from a 300 mg (30 mL) bottle is equivalent to 15 drops of oil, which translates to a 7.5 mg dose of CBD. However, plenty of people won’t even use a full dose, as they’re able to achieve relief with as little as 5-7 drops of oil, or about a 3.5 mg dose. CBD has long been recognized as an effective anti-inflammatory with specific properties that reduce the risk of cancer, metabolic disorders, and nerve cell degeneration. Some studies on mice have actually shown CBD to promote the creation of new nerve cells, which could potentially be highly relevant in numerous age-related neurodegenerative diseases. For example, CBD has been proven to block certain specific enzymes known to inhibit marrow-producing tissues, making it an excellent preventative treatment for age-related bone diseases like osteoporosis and arthritis.

See also  What kind of cbd oil is food for doggie dementia

A huge body of research supports the idea that using CBD as a simple, daily supplement provides natural disease-prevention qualities. A low-strength, 300 mg bottle of CBD oil is a good option for a daily supplement; many people take a single daily dose to increase immune health, increase homeostatic balance, and as general disease prevention. CBD oil can be used as a daily treatment to lower the risk of everything from mental disorders and diabetes to obesity and heart disease. Research has shown that the specific antioxidants found in CBD are more powerful than vitamins E and C in terms of physiological function. When used in serums and tinctures, this translates to a wealth of disease-preventing characteristics.

Top CBD researchers and physicians are starting to draw connections between CBD’s influence on brain-to-body communication. For example, Harvard University experimental psychologist and one of the world’s leading CBD researchers, Dr. Bradley E. Alger claims that the core of medicinal cannabinoid treatment lies at the chemical “matrix” between brain and body. According to Alger, CBD likely involves a chemical mechanism that interconnects brain activity and bodily homeostasis: “… the endocannabinoids are literally a bridge between body and mind. By understanding their function, we begin to see a mechanism that could connect brain activity and states of physical health and disease.”

In all honesty, it’s appearing more and more likely that daily small doses (less than 5 mg) of CBD oil may be an extraordinary means of long-term disease prevention. Also, considering the fact that excellent quality, low-concentration oils (300 mg or less) are available for less than $30, it appears that a 100% natural disease-preventing therapy is now a practical means for individuals of all income types – regardless of whether or not they have health insurance.
Preventative medication is likely the key to developing a happier, healthier, and more productive society, and CBD oil very well may be the necessary link that’s been missing for generations on end.

Mid-potency CBD oil (600 mg):

The 600 mg oil is a good “step-up” option for people who find that they’re having to take larger or multiple doses of the 300 mg in order to get effective results. In general, a lot of people use this strength for more moderate cases of anxiety, pain, inflammation, and digestive issues. A single dose is still the same 15 drops of oil, but instead of containing 7.5 mg of CBD, a 600 mg bottle will contain 15 mg per dose.

High-potency CBD oil (1,000 mg):

1,000 mg CBD oil is the highest-strength option. People have used it successfully treat insomnia, depression, anxiety/panic attacks, chronic pain, and/or as a buffer while weaning off drug or alcohol addiction. We do no recommended that first-time users start with this strength tincture.
Just like the 300 and 600 mg products, it comes in a 30 mL bottle, but a single 15 drop serving equates to a heavy 24 mg dose of CBD; unless your condition is fairly severe, you likely won’t need this high-strength tincture.

The main thing to consider when deciding the right strength of CBD oil is to realize that each person’s biochemistry is different. It’s important to start with the smallest possible dose and work up from there.