Cbd oil 300 mg for alzheimer’s

CBD Oil for Dementia and Alzheimer’s Disease: Benefits, Dosage, & Uses

Alzheimer’s disease is the most common age-related neurodegenerative disorder in the developed world.

CBD oil has recently shown a lot of promise as a new treatment for this condition.

How does it work, how can I use it, and what products are the best for treating this debilitating neurological condition?

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Alzheimer’s disease (dementia) is the most common age-related neurodegenerative disorder [2].

It’s becoming more common year by year, causing a lower quality of life to the individuals who suffer from the condition and their families.

Unfortunately, there’s no cure for Alzheimer’s disease yet. However, in recent years, there’s been a lot of hype around CBD oil as a promising treatment for the condition.

Does it live up to the expectations? How does CBD oil help slow the progression of Alzheimer’s disease? What does the research say?

Learn how it works and where to find the best CBD oils for dementia.

MEDICALLY REVIEWED BY

Updated on November 14, 2021

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The Benefits of CBD Oil For Dementia & Alzheimer’s Disease

CBD oil offers several key benefits to Alzheimer’s disease and dementia. However, it takes a while for CBD to work for this condition. For best results, CBD oil should be used for several weeks or months before you can expect any improvement.

The benefits of CBD oil for dementia and Alzheimer’s disease include:

  • May protect from beta-amyloid plaques (one of the underlying causes of Alzheimer’s disease)
  • May boost blood flow to the brain
  • Protects the brain from inflammation and oxidative damage
  • May prevent the buildup of TAU protein tangles (another common cause of the condition)

1. CBD May Protect the Brain from Amyloid-Beta

One study showed that cells pre-treated with CBD were better able to survive and resist the damaging effects of amyloid-beta.

Other studies have found that CBD and some of the terpenes found in the cannabis plant have the ability to inhibit an enzyme known as acetylcholinesterase.

This enzyme is responsible for breaking down a neurotransmitter known as acetylcholine, which plays a key role in the process of memory formation and retrieval. It’s especially active in a region of the brain known as the hippocampus, which is one of the first areas to show signs of damage during Alzheimer’s disease.

It’s believed that acetylcholine dysfunction plays a role in the formation of amyloid-beta plaques [18].

One of the main methods of treatment for Alzheimer’s disease is to improve acetylcholine function. This is generally done by inhibiting the breakdown of acetylcholine by an enzyme called acetylcholinesterase. This may slow the buildup of the damaging amyloid-beta and also improves memory function by increasing acetylcholine levels overall.

Many of the terpenes in full-spectrum CBD oils have been shown to inhibit acetylcholinesterase in-vitro, including:

  • Δ-3-carene [5]
  • 1,8-cineole [5]
  • Limonene [5]
  • Thymol [6]
  • γ-terpinene [6]

Both CBD and THC also inhibit acetylcholinesterase, helping to increase overall acetylcholine levels and reduce the production of damaging amyloid-beta [10].

Mouse studies have also shown CBD to reduce the neuroinflammatory response to amyloid-beta, as well as the reactive gliosis (neural cell swelling damage) that ensues [22].

Various cannabinoids have also demonstrated to have a specific activity in the hippocampus, suggesting a deeper support mechanism may also be at play [11].

2. CBD Oil May Boost Blood Flow to the Brain

One of the main benefits of CBD oil is through its indicated ability to increase blood flow to the brain.

It likely owes these effects to many of the terpenes contained in the plants, including:

  • Eucalyptol [12]
  • Caryophyllene oxide [13]
  • Borneol [14]

CBD itself also improves blood flow indirectly by improving the function of our main endocannabinoid, anandamide [15].

This naturally occurring cannabinoid is involved with regulating our arteries and veins, helping to control the blood flow throughout the body.

3. CBD Helps the Body Resist Oxidative Damage

There are many different causes of oxidative damage, including:

  • Heavy metal exposure
  • Smoking
  • Poor blood flow to the brain
  • Stroke
  • Poor glial cell function
  • Inflammation

CBD oil contains a number of different antioxidant compounds that help stop this damage from occurring in the first place.

Antioxidants work by essentially sacrificing themselves to take the damage from free radicals, so the cells don’t have to. They satisfy the free radicals’ need to steal electrons to balance their charge.

When looking for a CBD oil with these properties, it’s important to choose a product that contains the full spectrum of terpenes, cannabinoids, and flavonoids of the hemp or marijuana plant.

Some of the main antioxidant compounds in cannabis plants include:
  • Terpenes (eucalyptol, γ-terpinene, α-Terpineol, pinene) [6, 8, 9]
  • Cannabidiol (CBD) [4, 7]
  • Tetrahydrocannabinol (THC) [4]

Using CBD Oil for Alzheimer’s Disease

Getting started with using CBD oil for Alzheimer’s disease is simple.

You need to find a product that contains a full spectrum of terpenes, cannabinoids, and other phytochemicals from your local dispensary or online shop.

The usual dose of CBD for assisting in this condition can vary significantly; however, most people will start anecdotally somewhere around the 300 mg per day mark.

Depending on how this affects each person individually, the dose can either be increased or decreased.

Top Three Best CBD Oils For Alzheimer’s Disease

Will I Notice Benefits Right Away?

The main benefits of CBD oil for Alzheimer’s disease is the theoretical possibility of slowing the progression of the disease.

For this reason, the benefits won’t be as clear as they will be for other conditions such as pain or inflammation.

When it comes to Alzheimer’s disease, CBD oil should be taken every day, along with a balanced diet and regular exercise to get the best effects out of it. Take any medications as prescribed, and be sure to follow up regularly with your doctor, especially before you begin a CBD regimen to avoid interactions and/or if you have liver health issues.

The idea is that the CBD oil might make Alzheimer’s progression slower, helping to increase patients’ quality of life in the long-term. Of course, further clinical research will be needed to demonstrate any true or characteristic benefit.

What is Alzheimer’s Disease?

Alzheimer’s dementia is a chronic degenerative condition affecting the brain.

It results from a gradual breakdown of the grey matter in the brain, resulting in a number of psychological, behavioral, and cognitive changes.

Grey matter makes up the outer portion of the brain and is responsible for most of what we experience as thought. It’s where we make decisions, form memories, and solve problems.

The symptoms of Alzheimer’s Disease (dementia) come on gradually in 4 stages:

Stage 1 [1-4 years]
  • Mild lapses in memory
  • Increased irritability
Stage 2 [4-8 years]
  • Less interest in work or hobbies
  • Lower energy levels
  • Loss of recent memories
  • Language problems
  • Mild coordination problems
  • Mood swings
  • Irritability
  • Difficulty navigating
Stage 3 [8-12 years]
  • Rambling speech
  • Frequent memory issues with larger lapses in time
  • Depression
  • Speech difficulties
  • Inability to navigate effectively
  • Severe irritability and frustration
  • Mild-moderate coordination problems
  • Paranoia
Stage 4 [12+ years (end of life)]
  • Inability to walk or conduct normal life activities like bathing or using the bathroom
  • Inability to communicate effectively
  • Constant forgetfulness
  • Inability to recognize close family or friends
  • Confusion
  • Anger/mood swings
  • Fictional understanding of the world around them
  • Paranoia

The Possible Causes of Alzheimer’s Disease

Despite how common Alzheimer’s disease is, we still lack a thorough understanding of what exactly causes the condition. But, of course, there are a few prevailing theories that are gaining more evidence.

1. Amyloid-beta Plaques

Amyloid-beta is a sticky substance produced in the brain as a byproduct of normal neuron activity.

Normally, the glial cells – a group of special cells in the brain that act as the garbage disposal crew, among other things – come out at night to clear out these plaques, preventing them from building up and causing damage to the neurons.

Unfortunately, as we age, our cleanup crew doesn’t work as efficiently as it used to, allowing this amyloid-beta to build up and form thick plaques on the nerve cells and blood vessels. It is also likely that the fluids in the brain do not flush out as well as they used to also because of this plaque build-up.

Eventually, this causes the nerve cell to die off and blood flow to worsen.

As more of these cells continue to die, we start to see an increase in neuroinflammation, tau protein tangles, and the symptoms of Alzheimer’s disease progress.

Interestingly, a strong genetic link was found between the ApoE4 enzyme — an enzyme responsible for helping glial cells clear out amyloid-beta — and the risk of developing Alzheimer’s disease [20]. More recently discovered, ApoE4 is also linked to increased tau protein tangles, which are more strongly correlated to worse clinical symptoms than amyloid-beta plaques [21]. However, amyloid-beta plaques still probably play an important role in starting the disease process.

This makes preventing amyloid-beta a primary treatment aim for doctors trying to treat or prevent the condition.

2. Tau Protein Tangles

The most probable cause of Alzheimer’s disease is a buildup of another substance in the brain, known as tau proteins [3].

These tau proteins accumulate and become neurofibrillary tangles, which are toxic for neurons. However, this mechanism is poorly understood and is actually associated with a lot of other conditions. Any condition involving issues with these proteins are referred to as tauopathies.

Proteins are the main building blocks of life – much of what we’re made of can be distilled down to a protein. These tau proteins are just one type of protein that makes up our body. When they start to break down, they form unorganized “tangles”.

They’re essentially “knots in the nerve cells”, building up inside and hurting their ability to function normally.

There are a few experimental medications currently being tested that target these tau tangles, but some of the newest, most promising candidates are coming from the natural world in plant-based chemicals.

3. Poor Blood Flow to the Brain

As we age, blood flow to the brain may begin to decline.

Blood brings nutrients and oxygen to the cells. It’s also responsible for clearing out the garbage and toxic byproducts.

Think about it as living in a city.

Our houses are the cells, and the roads represent blood flow.

In order to get the water and food we need, we must build a road that connects our house to the rest of the city. We also need these roads for the garbage trucks to come and pick up the garbage we left out the night before.

If for any reason the road becomes blocked, we won’t have any access to food, and our garbage begins to pile up outside the house.

If this happens for too long, we will eventually die of starvation or from an infection from the rotting garbage.

It’s similar to the brain. If blood flow is bottlenecked for too long, the neurons will die of toxic overload and lack of nutrients or oxygen.

This is related to the pathological processes taking place with Alzheimer’s disease. The same amyloid-beta plaques that are neurotoxic also bind to blood vessels in the brain and reduce the ability of the blood vessel to exchange materials and clear things out. It also weakens the blood vessel wall and increases the risk of stroke. The risk of developing amyloid plaques on blood vessels is higher in people with more ApoE4 genetic inheritance.

Therefore improving blood flow to the brain is one of the primary goals of hospitals when treating the condition.

4. Glial Cell Dysfunction

Remember the garbage disposal cells we talked about earlier?

These are the glial cells.

They’re the most abundant cell type in the brain and for good reason.

They’re tasked with keeping the functional part of the brain, the neurons, working at their best – and they do that by fighting pathogens, removing dead neurons, keeping the neurons in place, bringing in oxygen and nutrients, and more!

As soon as the glial cells stop doing their job, the neurons will start to degrade, causing all kinds of issues with cognition. This includes Alzheimer’s disease or other forms of dementia.

The Apo enzymes are supposed to help glial cells and astrocytes to envelop and degrade amyloid-beta proteins before they become plaques. ApoE4 is the least efficient in carrying amyloid-beta to glial cells, thereby increasing the risk of developing Alzheimer’s dementia.

Anything that improves the health and function of the glial cells is theoretically likely going to go a long way in offsetting the processes behind Alzheimer’s disease.

5. Oxidative Damage

We all need oxygen to survive, but did you know it’s also the main reason we age?

Oxidative damage refers to a special type of chemical reaction known as “oxidation”.

Fitting name right?

Oxidation happens when molecules steal electrons from other molecules. When this happens, the molecules that had their electrons stolen start to degrade and fall apart. If enough molecules are affected on a cell, the cell may die.

When these molecules make up the outside of our nerve cells, this becomes a major problem.

Oxidative damage occurs whenever toxic compounds like amyloid-beta, lactic acid, heavy metals, or other free radical compounds are allowed to build up outside the cell.

Over time, oxidative damage may be a risk factor for Alzheimer’s disease.

Antioxidant support is a common method of protecting the brain, as well as every other organ in the human body. This is one of the strengths offered to us from the natural world, as some plants tend to be very high in antioxidant compounds.

Common Treatments for Alzheimer’s Disease

While no medication can stop Alzheimer’s disease, there are a few commonly used to slow down its progression. These can help the patient live more comfortably and prolong their independence.

Cholinesterase inhibitors (galantamine, rivastigmine, and donepezil) seem to prevent the breakdown of acetylcholine and work best for mild to moderate cases. These can provide some relief of symptoms and help control behavior.

N-methyl D-aspartate (NMDA) antagonists like memantine help those with moderate to severe Alzheimer’s disease maintain daily functions a little longer.

Since CBD can interact with certain medications, it’s important you talk to your doctor before combining it with over-the-counter or prescription drugs.

Summing it All Up: CBD and Alzheimer’s Disease

CBD oils may potentially offer an excellent array of benefits for the progression of Alzheimer’s disease, as suggested by early but exciting research.

The indicated effects of the oil are mainly preventative in nature, helping to slow the progression of the disease and improve the overall quality of life.

If you want to avoid the psychoactive effects, we recommend choosing a product that has less than 0.03% THC content.

But if you don’t mind the psychoactivity and live in a country or state where THC oils are legal, we highly recommend going with a product containing closer to a 1:1 ratio of CBD to THC for maximum benefits.

CBD Oil for Alzheimer’s & Dementia: How to Use & Dosage

Hemp and CBD oil were federally legalized with the 2018 Farm Bill, but scientists have been researching cannabidiol and its potential benefits for many years prior to the cannabis boom.

CBD products are gaining popularity at a rapid pace, mainly due to the number of conditions potentially alleviated by this compound.

Researchers are discovering new symptoms that CBD may be able to treat or help with in some way — from anxiety to inflammation and neurodegenerative diseases like dementia. CBD may provide relief to thousands of people across the country.

In this article, I’ll dive specifically into the potential application of CBD for dementia and the collateral damage it does to individuals suffering from this disease.

I want to explain the ins and outs of using CBD oil, how it can interact with dementia, and guide you through the brands that currently offer the best CBD products on the market.

Best CBD Oils for Dementia

Not all CBD is made equal. In fact, there’s a large degree of difference when it comes to the quality of ingredients in different CBD oils.

If you’re using this supplement for dementia, it’s important to find something clean and as high quality as possible — preferably in a higher potency.

Here are my top 3 recommended products that meet those requirements:

1. Royal CBD

Get 15% off all Royal CBD products. Use code “CFAH” at checkout.

  • Royal CBD uses organic hemp from local farmers
  • The company makes its products with supercritical CO2 extraction
  • Available as full-spectrum CBD and isolate
  • Four potency strengths to choose from: 250mg, 500mg, 1000mg, and 2500mg
  • The oil is potent — it contains up to 83.3 mg of CBD in each mL
  • Suspended in premium MCT oil for better taste and improved absorption
  • Every batch of product has been tested for potency and purity in a 3rd-party laboratory
  • The 2500 mg oil is available only in the unflavored option
  • Royal CBD products are slightly more expensive than the competition given the quality of ingredients this company uses
My Thoughts on Royal CBD:

Royal CBD is a rising star of premium CBD oils — offering high-quality products made from organically-grown American hemp. The oil contains the full spectrum of cannabinoids and terpenes, providing the synergy from these compounds and contributing to the higher efficacy of CBD.

Aside from extracting its oil with pressurized CO2, Royal CBD sends each batch of product to independent laboratories for testing. This is used to confirm the potency and purity of every bottle sold.

The oil offers 250 mg to 2500 mg of full-spectrum CBD per bottle, suiting both novice consumers and experienced users or those with more severe symptoms.

I like how this product tastes. Because it’s suspended in high-quality MCT oil, it doesn’t leave that bitter, earthy aftertaste on the tongue. The flavor is masked by nutty rather than earthy notes.

But if you prefer other forms of administration, Royal CBD offers convenient soft gel capsules (25 mg of CBD per piece) and isolate-based gummies (10 mg of CBD per count). These forms may not have the fastest onset but are easier to dose and take on the go.

2. CBDPure

  • CBDPure’s products are sourced from organic hemp grown in Colorado
  • The company uses CO2 extraction in all their products
  • The oil is sold in larger bottles than the competition (60 mL)
  • These products are made with full-spectrum hemp extract
  • The entire product lineup has been tested in an independent laboratory for quality assurance
  • Narrow product range
  • The oil is less potent than Royal CBD
  • No isolates available
My Thoughts on CBDPure:

If you don’t know where to start and need plenty of information about each stage of the CBD oil manufacturing stage, CBDPure is one of the best brands you can choose. This company is very transparent and uses organic hemp in every product they offer.

Similar to Royal CBD, CBDPure prefers to keep things simple, offering two types of products — oil drops and capsules.

Their CBD oil comes in 60 mL bottles but is slightly less potent than Royal CBD, so you may choose this option if you benefit from lower doses, which isn’t common for people with dementia symptoms.

If you want a product that will give you more CBD and offer consistent dosing, you may go for CBDPure softgels. Each capsule comes with 25 mg of full-spectrum cannabidiol.

3. CBDistillery

  • CBDistillery uses Colorado-grown hemp
  • The company’s products are available as ‘full-spectrum’ or ‘pure oil’ (zero THC)
  • Broad product selection
  • The oil is very potent — up to 5,000 mg of CBD per bottle
  • CBDistillery sends samples of their CBD oil to a third-party laboratory for thorough content analysis
  • It’s one of the most affordable brands on the market
  • Their hemp isn’t organic
  • The CBD oil is available only in the unflavored version
My Thoughts on CBDistillery:

CBDistillery is a Colorado-based brand with a diverse product selection. Out of all their products, my favorite is their full-spectrum CBD oil. Interestingly, this product is also available as pure oil, with no THC inside.

The oil comes in a wide potency range, from 250 to 5,000 mg of total CBD. The company caters to different types of CBD consumers and budgets.

Their oil may not be as high quality as Royal CBD or CBDPure — it’s not made from organic hemp — but this is well justified by the cost of their products. CBDistillery doesn’t sell the best CBD oil out there, but that’s definitely the best CBD oil in this price range.

On top of making affordable CBD products, CBDistillery is known for its influence on raising awareness about the health benefits of cannabis. They have created the #CBDMOVEMENT hashtag to provide education for customers in their social media.

What is Dementia?

Dementia is not a disease, per se. Instead, it’s a group of conditions that impair the functioning of your brain.

Generally, dementia is characterized by the deterioration of at least two important brain functions, such as weakened judgment and memory loss. As a matter of fact, any form of dementia can compromise cognitive functioning.

As with every health condition, there are certain symptoms that can help diagnose dementia, namely:

  • Impairment of motor functions and coordination
  • Memory loss usually noticed first by a close family member
  • Personality changes
  • Difficulty with problem-solving or reasoning
  • Anxiety, agitation, depression, or paranoia
  • Confusion
  • Hallucinations and awkward behavior
  • Problems handling complex tasks

Is Dementia the Same as Alzheimer’s Disease?

Alzheimer’s is the most common form of dementia, so dementia is just a category that Alzheimer’s Disease belongs to. Yet, there are other forms of dementia besides Alzheimer’s.

Dementia can be categorized into four different forms of dementia:

  1. Frontotemporal dementia: the type where the nerve cells in the temporal and frontal lobes of the brain degenerate. Frontotemporal dementia affects the parts of the brain that control behavior, language, and personality
  2. Lewy Body Dementia: the most common type of progressive dementia, Lewy Body Dementia occurs when abnormal clumps of protein start to form in the brain.
  3. Vascular Dementia: it’s the second most prevalent form of dementia. It’s caused by the damage in the blood vessels that limits direct blood supply to the brain and may lead to blood vessel clogs or stroke.
  4. Mixed dementia: it typically involves some combination of Alzheimer’s Disease and other forms of dementia. While Alzheimer’s may strike those over the age of 65, mixed dementia occurs upon further progression.

What Are the Benefits of CBD for Dementia?

CBD has been proposed by scientists as a natural alternative for many serious conditions including memory loss conditions, anxieties, and sleep disorders.

CBD is a potent antioxidant, anti-inflammatory, and neuroprotectant, so it may greatly improve brain functioning, which is essential in slowing and halting the progression of neurodegenerative diseases.

Below I explain how CBD oil could improve different forms of dementia based on the latest scientific findings.

1. Alzheimer’s Disease

Research shows a clear link between CBD and the reduction of inflammation and brain cell decline.

Inflammation increases the negative impact of Alzheimer’s disease. It’s a core cause of this condition. The more inflamed the brain, the greater the damage.

Alzheimer’s sufferers often show a path of rapid decline and degeneration of brain cells in certain regions. Scientists have recently found that CBD has the potential of improving the plasticity of the hippocampal region — the part of the brain responsible for cognitive functioning and forming memories.

In clinical trials, researchers have found that the endocannabinoid system is involved in neurotransmission, neuropathology, and neurobiology of different forms of dementia, including Alzheimer’s Disease.

2. Vascular Dementia

As mentioned, people who have vascular dementia typically encounter problems with planning, reasoning, memory, judgment, and other thought processes due to brain damage from reduced blood flow to their brains.

A 2016 study conducted by the National Institute of Health (NIH) found that activating cannabinoid receptors in the brain promoted the recovery of blood flow to the brain.

3. Parkinson’s Disease Dementia

Parkinson’s is a progressive neurodegenerative disease mainly affecting middle-aged and elderly people. Some symptoms of dementia may be the result of Parkinson’s disease — referred to as Parkinson’s disease dementia.

Scientists suggest that Parkinson’s disease may derive from lowered dopamine production and is most commonly expressed by muscular strains, tremors, and slow, flawed movement.

A digestive imbalance may also be a significant factor in the progression of Parkinson’s and the seriousness of its symptoms. Cannabinoids such as CBD have been shown to produce neuroprotective and antioxidant effects on the brain which, along with its anti-inflammatory properties, can be effective in managing Parkinson’s disease-induced dementia.

4. Lewy Bodies Dementia

Lewy Bodies is a scientific name for the alpha-synuclein protein deposits in the brain. These buildups can lead to problems with judgment, sleeping, behavior, movement, and mood.

Research has found that CBD may reduce anxiety and stabilize mood. In addition, the anti-inflammatory effects of CBD can reduce the severity of motor symptoms and help with sleep regulation.

5. Frontotemporal Dementia

As the brain loses more cells in its frontal or temporal lobes, this can trigger symptoms of depression and psychosis. Unlike many antipsychotic drugs, CBD may alleviate tremors, anxiety, and rigidity without the side effects associated with prescription drugs.

6. Huntington’s Disease Dementia

Also known as Huntington’s chorea, this disease is an inherited disorder that leads to degeneration of brain cells — which often results in symptoms of dementia.

The earliest symptoms of this condition are often mild and involve problems with mood and concentration. As the disease progresses, a person may suffer from a general lack of coordination and an unsteady gait (walking motion).

A 2016 study conducted by researchers from the University of Madrid discovered that CBD’s antioxidant and anti-inflammatory properties can be beneficial for managing Huntington’s disease and is safe even at very high doses.

What Experts Say About CBD Oil and Dementia

Scientists are going to use a CBD/THC oral spray Sativex to treat dementia patients in the first major trial in the UK. The study is led by researchers at King’s College London and funded by Alzheimer’s Research UK.

Researchers will be investigating the efficacy of Sativex, a drug already approved for patients with multiple sclerosis, by observing 60 patients between the age of 55–90 who are living in care homes for the duration of the trial. The study will aim at easing aggression and agitation, one of the main symptoms of dementia.

Dag Aarsland, a psychiatrist and the professor supervising the trial says:

“Most often, people associate Alzheimer’s disease with memory problems, but this is just one aspect of a complex condition that can affect people in different ways. Many people with Alzheimer’s can become agitated or aggressive, and this can pose difficulties for the person with the condition and those closest to them.”

If full-spectrum extracts prove effective as a dementia treatment, this can be a breakthrough for modern medicine considering that scientists have been struggling to come up with effective solutions for almost two decades.

“With no new dementia treatments in over 15 years, it is vital that we test a wide range of approaches to find effective ways to help people living with the condition,” said David Reynolds, Ph.D., of Alzheimer’s Research U.K. Reynolds underlines the importance of finding a medicine that will not only slow or stop the progression of dementia but also benefits people’s day-to-day performance.

“Based on some preliminary studies in other populations, like younger individuals with bipolar disorder and schizophrenia, as well as animal studies, there is at least some reason to theorize these drugs would have a benefit,” follows Dr. Nathan Herrmann, head of geriatric psychiatry department at Sunnybrook Health Sciences Centre in Canada, showing support for his colleagues in the UK.

Sativex has equal amounts of THC and CBD. Hemp-derived CBD oil contains only 0.3% THC and there are no trials that would look into the effects of this cannabis solution on dementia.

What’s the Best CBD Oil Dosage for Dementia?

There are no definite dosage guidelines when it comes to using CBD oil for dementia. However, various studies have been performed on the efficacy of different CBD doses for Alzheimer’s patients.

A study conducted in 2014 found that higher concentrations of CBD may be required until the effects take hold. The study was conducted on transgenic mice.

Given the lack of regulation in the CBD marketplace, the best thing you can do is observe the effects of different dosages and report to a foundation or science institute that specializes in seeking new forms of dementia treatment. With more self-reports from patients, healthcare professionals will be able to come up with some general guidelines for people with dementia in the future.

Where to Buy CBD Oil for Dementia

If you’ve been considering taking hemp-derived CBD oil for dementia, you can buy one in a local cannabis dispensary or search for CBD products online.

I prefer buying CBD oil online. The majority of CBD supplements are sold this way, so you get access to a wider range of products. Cannabis dispensaries have plenty of CBD supplements as well, but they may not carry the best products out there, not to mention that they might have stood on the shelves for a long time after arrival — which is not the best way to store CBD oil.

Buying CBD oil online is also more convenient. You can easily check the reputation of your potential supplier. Always make sure that your manufacturer uses organic hemp, makes its products with CO2 extraction, and posts testing results from 3rd-party laboratory screening.

Finally, online stores are less expensive than dispensaries. Usually, you will pay around twice as much for CBD oil in a local dispensary than you would for a product ordered online.

It’s worth waiting the extra 2-3 days to get exactly what you’ve been looking for without spending an arm and a leg.

Final Thoughts on Using CBD Oil for Dementia

Dementia is a severe neurodegenerative condition. It’s not a disease per se; instead, it’s a set of symptoms that describe a predictable set of symptoms. It can take many forms, from Alzheimer’s Disease to vascular dementia and Lewy Bodies Dementia. Dementia can also result from the progress of other neurodegenerative diseases, such as Parkinson’s or Huntington’s Disease.

Scientists have been investigating the neuroprotectant properties of CBD and its influence on neurodegeneration for quite some time now. While the evidence isn’t conclusive yet, results from animal studies and preclinical trials indicate that the endocannabinoid system and cannabinoids can be used to prevent neurodegeneration and reverse its impact with consistent administration.

If you’re interested in trying CBD oil for dementia, make sure to contact your doctor first to figure out whether CBD is good for you, especially if you’re already using some medication.

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Nina Julia

Nina created CFAH.org following the birth of her second child. She was a science and math teacher for 6 years prior to becoming a parent — teaching in schools in White Plains, New York and later in Paterson, New Jersey.

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Effects of THC-Free CBD Oil on Agitation in Patients With Alzheimer’s Disease

This is a randomized, double-blinded, placebo-controlled, crossover trial that aims to 1) determine the efficacy of THC-free cannabidiol (CBD oil) in reducing the severity of agitation among participants and 2) determine whether THC-free CBD oil can reduce the burden on caregivers and increase the participants’ quality of life.

Condition or disease Intervention/treatment Phase
Alzheimer Disease Dementia Major Neurocognitive Disorder With Aggressive Behavior Drug: THC-free CBD Oil Drug: Placebo Phase 2

Individuals with Alzheimer’s and other forms of dementia often go through a period of significant behavioral and psychological symptoms of dementia (BPSD). It is estimated that up to 90% of persons with dementia (PWD) experience behavior problems at some point. BPSDs can be challenging for both unpaid family caregivers as well as paid caregivers. Family caregivers provide the bulk of care for PWD and number over 15 million. One of the most common types of BPSDs is agitation with a prevalence of up to 87%, based on a recent systematic review. Agitation can lead to impaired daily functioning, prolongation of hospitalization, reduced time to institutionalization, and is associated with higher mortality. Additionally, agitated behavior is associated with increased injury to both patients and caregivers. Based on the 2018 Alzheimer’s disease drug development pipeline report almost 70% of clinical trials related to BPSD are dedicated to agitation behavior. Finding ways to address agitation is necessary to improve overall quality of life for PWD and their caregivers. Currently, there are no medications available specifically for the treatment of BPSDs. The use of benzodiazepines, antipsychotics and mood stabilizing agents are common, but the risks and side effects often outweigh any benefits.

Several small studies have investigated the use of cannabinoids in the treatment of pathology and symptomology of Alzheimer’s disease (AD), as well as treatment of the agitation component of BPSD. A handful of these studies showed that the symptoms of BPSD were decreased with the use of cannabinoids. However, due to small sample sizes, study design, and short trial duration of these studies, the efficacy of these agents on BPSD cannot be confirmed. In addition, cannabinoids have demonstrated anti-oxidant and anti-inflammatory effects, and both processes have been indicated as major contributors to the neurologic effects of AD. Some evidence exists that agitation is related to this neuroinflammatory process. This study will examine the effects of cannabinoids on the behavioral and psychological symptoms of individuals with a dementia diagnosis.