CBD Oil And Her2-positive Breast Cancer

Recent research on CBD + breast cancer – Recently, I gave a lecture at the senior center in Manchester about CBD. The lecture was very well attended, and the interest and questions were even Comparing the antitumoral activity of single-molecule THC and whole plant cannabis Looking for alternative cancer treatments? Read Headcovers take on cannabis oil & how it can help fight breast cancer. Learn more about CBD Oil today!

Recent research on CBD + breast cancer

Recently, I gave a lecture at the senior center in Manchester about CBD. The lecture was very well attended, and the interest and questions were even better! Having the opportunity to help the community is something all of the doctors in our office love to do, and public lectures are one of the ways we serve the community. Also, we have an opportunity to dive into the research a little deeper when we prepare for these talks. Today’s blog post will be centered around a very interesting studying including breast cancer and medical marijuana.

In this study, they found cannabinoids significantly reduce the growth of erbB2-positive (also known as HER2 or neu) breast cancer tumors in a mouse model. This type of breast cancer (many other type of breast cancers not discussed with this study) is known to be more aggressive and metastatic, and less responsive to therapy. HER2 positive breast cancer means there is a gene that is being over expressed that leads to cell proliferation.

The study took mice that were genetically predisposed to HER2 overactivation – aka mice given HER2 positive breast cancer, and then given either THC, CBD, or nothing (control or ‘Veh’) over the course of 100 days and measured many ways during this time period. Below is a Xenograph – the standard of assessing how tumor cells respond to a treatment (usually new potential chemotherapeutics).

That is a pretty remarkable response to CBD and THC treatment compared to doing nothing. Unfortunately this research did not use a chemo-therapy drug for comparison, however we know there are not many chemotherapies that response to HER2+ breast cancers.

To be clear, this article is NOT to be taken that CBD or THC is a proven treatment for breast cancer. It is recommended that a patient with any type of breast cancer works with an oncology team to discuss the best treatment for their case. However, I do believe that CBD/THC products need to begin to be included in human oncology trials. I am confident that this ‘normalizing’, ancient botanical medicine is not going to make things worse in someone’s therapy. Medical marijuana is widely accepted to be a powerful anti-nausea, appetite stimulator, and pain reducer – all common symptoms that challenge patients going through conventional treatments.

THC vs. Breast Cancer

It’s no secret that many cancer patients are using cannabis to help manage pain, fatigue, nausea, and other side effects of chemotherapy. Less well known is the fact that extensive preclinical research shows that plant cannabinoids — most notably, tetrahydrocannabinol ( THC ) and cannabidiol ( CBD ) – produce antitumor responses in various animal models of cancer.

The vast majority of this preclinical research has examined the anticancer activity of pure compounds, mainly THC isolates. But medical cannabis patients aren’t using pure, single-molecule THC to battle cancer. Instead, they are consuming whole plant cannabis oil extracts that include hundreds of compounds, many of which also have therapeutic properties. These artisanal cannabis oil preparations are available in licensed dispensaries in states where medical cannabis is legal and elsewhere via the unregulated black market.

Thus far, however, few rigorous studies have analyzed the effects of whole plant cannabis extracts. So a team of Spanish researchers, led by Cristina Sanchez at Complutense University in Madrid, decided to compare the efficacy of pure THC isolates and THC -rich oil extracts in a series of preclinical experiments that focused on breast cancer. (The oil extracts were provided by Aunt Zelda’s, a California-based medical cannabis producer.) The researchers also investigated the effects of pure THC and an artisanal THC -rich oil formulation when each was combined with standard chemotherapy drugs.

Their findings were reported in a 2018 article – “Appraising the ‘Entourage Effect’: Antitumor action of a pure cannabinoid versus a botanical drug preparation in preclinical models of breast cancer” – which was published in the journal Biochemical Pharmacology. The phrase “entourage effect” in this context refers to the full-spectrum synergistic interplay between numerous cannabis compounds – cannabinoids, terpenes and flavonoids – that impart a therapeutic impact that’s greater than the sum of the plant’s individual components.

Spoiler alert: Both THC and the artisanal THC -rich oil were shown to have antitumoral properties, but the oil worked better than the THC isolate for three different breast cancer subtypes.

Tricky to Treat

It is estimated that one in eight women will develop breast cancer. Breast cancer is tricky to treat because there are few biomarkers that signal when someone has the disease, and many patients show or develop resistance to current therapies. Moreover, several specific types of breast cancer respond poorly to modern treatment. These difficulties underscore the importance of exploring new treatments for breast cancer.

Two biomarkers frequently used to diagnose breast cancer are hormonal receptors (the estrogen receptor and progesterone receptor) and the HER2 oncogene (a gene which can transform a normal cell into a tumor cell). But a more aggressive malignancy, known as “triple-negative breast cancer,” doesn’t express hormonal receptors or the HER2 oncogene. No targeted therapy exists for triple-negative breast cancer, so patients are treated with harsh chemotherapies that indiscriminately kill proliferating cells, whether cancerous or not.

These three types of cancer – hormone-sensitive, HER2 , and triple-negative – were used as models for “Appraising the entourage effect.”

In all models of breast cancer studied, in vitro as well as in vivo, the whole plant extract was significantly more effective at producing anticancer effects than single-molecule THC . These results were largely consistent for type of cancer and type of model. Researchers tested the compounds in cell cultures (petri dishes) and in rodent models (mice).

THC & Hormone-Sensitive Breast Cancer

In the case of hormone-sensitive breast cancer cells, whole plant extract was found to be 15-25% more potent than THC alone. In live-animal models single molecule THC exhibited no significant antitumor response, unlike the whole plant extract, which had a pronounced antitumor effect. Testing on lab animals is a necessary step towards establishing the efficacy of a specific clinical treatment.

When the cannabinoid preparations were added to tamoxifen, a standard chemotherapy drug, in a cell plate, the combined therapy was about 20-25% more effective than chemotherapy alone. But these results were not replicated in live-animal trials. Importantly, the cannabinoids also did not negatively impact the efficacy of the chemotherapy. This suggests that at the very least using cannabis as an add-on treatment to deal with common side effects of chemotherapy, like nausea and appetite loss, won’t impede chemotherapy’s ability to destroy cancer cells.

In hormone-sensitive breast cancer, it appears that THC produces effects via interaction with the CB2 cannabinoid receptor. CB2 receptor activation has received significant attention because of its potential to treat diseases while avoiding the “high” mediated by the CB1 cannabinoid receptor, which THC also activates. When THC binds to CB1 , it causes the swimmy-headed feelings of intoxication associated with cannabis consumption.

THC & HER2 -Positive Breast Cancer

Whole plant extract was found to be significantly more potent than THC for HER2 -positive breast cancer cells. Both single-molecule THC and whole plant extract showed antitumor effects when the experiment was replicated in mice. Additionally, both THC and the whole plant extract amplified the anticancer effects of lapatinib, the standard chemotherapy drug for HER2 breast cancer.

As with hormone-sensitive breast cancer, THC ’s antitumoral effect in HER2 -positive breast cancer experiments was shown to be mediated by the CB2 cannabinoid receptor. Published in the Proceedings of the National Academy of Science, a subsequent report by Cristina Sanchez and other Spanish scientists noted that HER2 and CB2 receptors are often found in the same exact place on cells.

CB2 actually conjoins with HER2 – forming what is called a dimer – and this dimerization is associated with poor treatment outcome for breast cancer. The PNAS report shed new light on THC ’s anticancer mechanism of action: When THC binds to the CB2 receptor, it breaks up the CB2 – HER2 dimer, triggering a chain reaction of signals that culminates in tumor regression.

THC & Triple-Negative Breast Cancer

Triple-negative, the breast cancer subtype with the worst prognosis, does not generally respond well to chemotherapy. But the Spanish group found that THC and THC -rich cannabis oil both offer some hope in improving treatment outcomes for this highly aggressive cancer. Again, the whole plant extract was found to be more effective than THC alone in decreasing the viability of cancer cells in vitro as well as in mouse model studies.

There are several other examples where a combination of plant cannabinoids and standard chemotherapy agents have produced a heightened antitumoral response that exceeded the potency of either therapy alone. A phase 2 clinical trial tested the strength of Sativex, an equal THC and CBD mixture, combined with temozolomide, the “gold-standard” chemo for brain cancer, and the results were positive.

Cancer patients are often treated with several single-compound drugs in an effort to create a treatment that can hit multiple targets. “Although current medicine is mostly based on the use of pure compounds that have single targets,” the Spanish scientists write, “it is increasingly obvious that for diseases as complex as cancer, multi-target approaches could conceivably be more effective.”

The results of the Spanish study, along with compelling data from other researchers, suggest a promising future for whole plant cannabis oil extracts and multitarget cancer therapies. But the Western medical system and its typical drug development procedures are not conducive to the approval of complex botanical preparations as multitarget medicaments – in part because elucidating a precise mechanism of action when numerous compounds are involved is much more difficult than studying a single-molecule pharmaceutical that’s geared toward a single, primary outcome.

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The Takeaway

The fact that both the THC isolate and the whole plant cannabis extract were shown to be effective at reducing tumor viability is truly groundbreaking and should be an impetus for advancing the development of nontoxic, cannabinoid-based treatments for breast cancer.

Cannabinoid therapies are particularly promising for tumor-producing cancers given that “no overtly cannabis-resistant tumors have been described so far,” according to the Spanish researchers. “Considering how different cancer subtypes are, and the fact that the viability of non-transformed cells is not affected by cannabinoids at the concentrations they kill tumor cells, it is tempting to speculate that these compounds tackle essential, as yet unidentified, cellular functions that all cancer cells share, and that are absent in their non-cancerous counterparts.”

The Spanish breast cancer study underscores the importance of the entourage effect by demonstrating that full spectrum artisanal cannabis oil extract with numerous components is more effective than pure THC .* “[A]lthough the pharmacology of cannabis drug preparation extracts is obviously more complex to study,” the researchers acknowledge, “this therapeutic approach has the potential to produce better therapeutic responses than pure cannabinoids.”

The Spanish scientists emphasize that the whole plant cannabis drug preparation “did not, in any case, diminish the antitumor efficacy of any of the standard treatments.” That’s good news for cancer patients who use cannabis to manage the adverse side effects of chemo. Cannabis is very likely a safe add-on therapy for treating pain and nausea and for appetite stimulation. And it may also increase the efficacy of standard chemotherapy treatments, which means that chemo could be more effective – requiring lower and less toxic doses – when used in combination with cannabis.

Alex Andia, who holds his PhD in Chemistry, teaches Organic Chemistry at the City University of New York – City College. He is also the brains behind Chemical Makeup, a non-profit dedicated to promoting the queer voice in science.

Copyright, Project CBD . May not be reprinted without permission.

Footnote

*An interesting finding from the Spanish breast cancer study pertains to the not fully understood role of terpenes, the aromatic compounds that give cannabis its distinctive smell. The scientists created a “terpene cocktail” composed of the five most prominent terpenes in the full-spectrum cannabis oil extract: beta-caryophyllene, alpha-humulene, nerolidol, linalool, and beta-pinene. When added to the THC isolate, however, this terpene cocktail failed to increase the antitumoral efficacy of the single-molecule cannabinoid. This could mean that mixing a few terpenes with pure THC does not adequately recreate the qualities of a full-spectrum cannabis oil extract. Or it could be that other compounds in the oil extract are responsible for enhancing THC ’s anticancer impact. The authors note that the whole plant cannabis oil extract used in the study also contained measurable amounts of cannabigerol ( CBG ) and tetrahydrocannabinolic acid ( THCA – the ‘raw’ form of THC that won’t get you high). CBG has demonstrated effectiveness against colon cancer in preclinical models, and THCA is known to interact with a PPAR (nuclear) receptor that mediates apoptosis (cell death) in cancer cell lines. A combination of all these compounds may be required to achieve the antitumoral response observed in the Spanish breast cancer study.

3 Ways Cannabis Oil Helps Fight Breast Cancer

More than 60 peer-reviewed studies on medical marijuana were conducted between 1990 and 2014 for conditions ranging from breast cancer to Parkinson’s disease. The vast majority of these studies (68.3%) found marijuana had medicinal benefits, 23.3% were inconclusive, and only 8.3% yielded negative results. Medical marijuana is beneficial in its various forms, and marijuana and cannabis oil may have to the potential to fight breast cancer and other diseases.

In the U.S., 44 states have medical marijuana laws on the books, which means 85% of the country should have access to medicinal cannabis for treating a wide range of debilitating conditions. In reality, the laws governing this vary greatly by state and obtaining medical marijuana is difficult, if not impossible, in many of the 44 states due to the way the laws are written. Moreover, marijuana is still illicit on a federal level and legislation dating back to 1937 needs to be rewritten.

Forms of Medical Marijuana

Medical marijuana is available in many different forms:

  • Joints smoked like illicit marijuana
  • It is also available to vape
  • Edibles such as tea, cookies, popcorn, crackers, nut mixes, lollipops, ice cream, gummy bears, chocolate bars, chews, and many other kinds of food.
  • Sublingual sprays
  • Tinctures
  • Transdermal patches
  • Topical ointment

Each method has its own pros and cons so it is important to talk to your physician about what form will work best for your specific medical condition.

What is Cannabis Oil?

Cannabis oil is a thick, sticky, resinous substance extracted from the cannabis plant (Cannabis sativa or Cannabis indica). Cannabis oil is obtained by separating the resins from cannabis flowers using a solvent extraction process. Cannabis oil is the most concentrated and potent of the three main cannabis products, the other two being the actual cannabis flower (marijuana) and resin (hashish).

Like marijuana, cannabis oil contains two primary ingredients: the high-inducing THC (tetrahydrocannabinol) and cannabidiol (CBD), the second most active ingredient in marijuana. Typically, oils marketed for medicinal uses contain much less THC than an average joint, however, both THC and CBD are touted for their curative powers. Unlike medical marijuana,cannabis oil is legal in all 50 states, so long as it does not contain THC.

High quality cannabis oil can be used medicinally via several methods:

  • Orally
  • Vaporized
  • As a suppository
  • Applied topically

Cannabis Treatment: Breast Cancer

Cannabidiol and its related cousin chemicals, all broadly called cannabinoids, show some benefits for reducing chemotherapy-related pain and other symptoms like vomiting and nausea in patients. Other research has shown cannabinoids can uniquely target and kill cancer cells and anecdotal cases speak to supposedly miraculous recoveries from cancer as a result of using cannabis oil.

Unfortunately, some people with cancer have been scammed, taking cannabis oil sold illegally through drug dealers. Research does not show any evidence cannabis oil is a cure, and moreover, cannabis oil sold illicitly on the street is often contaminated with dangerous ingredients and may not even contain any THC or CBD. So the question remains, does cannabis oil have any benefits for breast cancer patients? Here is a look at three potential uses of high quality cannabis oil for breast cancer.

1. A research study showed CBD inhibits a gene called Id-1.

Researchers believe Id-1 triggers the metastatic process responsible for spreading cells from the original breast tumor to other parts of the body such as the brain and lungs. “This is the first evidence that a cannabinoid can target the expression of an important breast cancer metastasis gene,” said Manuel Guzman, a Spanish expert on cannabinoids and cancer. He described the California study as giving “preliminary insight into the question of whether CBD could be used clinically to treat metastatic breast cancer.” The experiments in this study were conducted in cultured cells, therefore animal model research is the next step to determine if cannabis oil has the potential for treating metastatic breast cancer.

Moreover, Id-1 is just one of many genes involved in breast cancer metastasis, so future research also needs to examine the impact of CBD on other metastasis genes.

2. CBD oil may help slow or stop the spread of cancer.

A California woman received a grim diagnosis of an aggressive form of breast cancer called HER2-positive, already in late stages and metastasized to her lungs. She was told she only had 18 months to two years to live. She used three different homemade herbal remedies containing high amounts of CBD. She made the concentrate out of marijuana plants using low enough temperatures to retain the medical benefits of the CBD, while minimizing the psychoactive effects of the THC. The end results were a salve applied topically to her breast, a tincture she drank as a tea in the morning, and a high-potency oil kept in a syringe for measurement purposes, administered through a suppository. The latter allowed the medicine to be absorbed more efficiently. Within five weeks of treatment, a scan showed her lymph nodes were clear and the tumors were basically gone. Her homemade CBD treatment resulted in halting the spread of an especially aggressive form of breast cancer. Although this story is anecdotal, it speaks to the potential of CBD for treating breast cancer.

3. Cannabis is useful in combatting multiple cancer-related symptoms including anorexia, chemotherapy-induced nausea and vomiting, pain, insomnia, and depression.

The safety of cannabis is acceptable with generally tolerable and short-lived side effects. Preclinical data suggest cannabinoids are effective in treating and preventing chemotherapy-induced peripheral neuropathy. Preclinical data indicate cannabinoids may directly impart anti-tumor activity, possibly most notably in central nervous system malignancies. While anecdotal evidence is promising regarding the curative effects of CBD for breast cancer, large-scale clinical studies are needed to test this hypothesis.

Suggested CBD Oils:

  • Pure Organic Wintermint CBD Oil – 750 mg
  • Pure Organic Wintermint CBD Oil – 3000 mg

Suggested Capsule forms of CBD Oil:

Do you know someone who has used Cannabis Oil? Was it helpful? Tell us in the comments below!

It’s irresponsible to post anecdotal stories as proof. Anecdotal stories have led to all kinds on crazy treatments of breast cancer over the years. You would be shocked to know what treatments were touted based on single experiences. Anecdotal stories should be removed.

CBD oil it’s good for dense breast tissue ? Please help I need your kindheart advice about my problem . Thank you and God bless us all.

Thank you for sharing and spreading awareness! Cannabis is really indeed magical. As studies progress, it unfolds a lot of possible uses and applications in science and medicine. I hope this could be the future treatment of a lot of diseases.

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CBD stands for cannabidiol. It is the second most common of the active ingredients of cannabis (marijuana). While
cbd for pets is an integral part of medical marijuana, it originates directly from the hippopotamus, which is a cousin of the marijuana plant. While CBD is part of marijuana (one of the hundreds), it does not in itself cause a “high”. According to a report from the World Health Organization, “CBD has no effects suggesting abuse or dependence. So far, there are no signs of public health problems associated with the use of pure CBD.

wow! I didn’t know that cannabis can also help cure cancer disease. it’s so amazing how cannabis works in different types of diseases.

Of course, on the first place 68.63% of the studies prove that marijuana has medicinal benefit that many people can people get through it. Like marijuana, cannabis oil contains marijuana active ingredients.

Thank you for sharing your article on cannabis oil as a treatment for breast cancer. It’s interesting to know how preclinical data shows how cannabis is effective in treating and preventing cancer-related symptoms like chemotherapy-induced nausea and vomiting, pain, insomnia, and depression. Although more tests and clinical studies are needed, just like you said, it may be something worth a try and looking into. I can only imagine how much pain a person in chemotherapy goes through every time. We’d be looking out for more updates and studies on this subject. Thank you for sharing!

Excellent article! I cannot believe cannabis oil can impact on cancer survival. Would love to hear more about this!

After an ultrasound and mammogram, I was diagnosed in Feb/17 with stage 3A breast cancer with lymph node involvement under my right arm. I did have a double mastectomy and removal of cancerous lymph nodes under my right arm, but I refused chemo, radiation and hormone suppressants. I knew I needed my immune system to stop my cancer spread, even with the removal of the lymph nodes. I’m not sleeping well. I have nerve damage from removal of my lymph nodes under my arm and scar tissue on my chest from the mastectomy. A lesion has been found on my cervix and I’m due for an MRI mid-June this year. I’m about to start taking high CBD 20:1 MCT oil, 1/2 tsp morning and evening. I’m hopeful that it will help me sleep and help with the pains from my mastectomy, at least. Any other benefit of stopping spread or healing would be an absolute blessing. Great forum, thanks to all who shared. I feel alone on this most of the time.

Hi Patti. Just read your post from a last year. I’m in a similar position now – seeing oncologist in a few weeks, but feel quite confident in refusing chemo and hormone suppressants. I was just wondering how you are getting on? I really do hope you are doing well. Would be great to hear from you if you have a chance. Best wishes Trish

Question about tamoxifen and interactions with cannabis – wondering if a topical CBD would interfere with the use of tamoxifen for my mom and her breast cancer?

Hi Carey, We would recommend that she ask her doctor to be certain. Best of luck to her with her treatments and I hope that all is going well!

I was so surprised! “A research study showed CBD inhibits a gene called Id-1. Researchers believe Id-1 triggers the metastatic process responsible for spreading cells from the original breast tumor to other parts of the body such as the brain and lungs. ” Thanks for sharing!

I was diagnosed with Lymphoma T-Cell cancer in April 2018. I have gone thru 5 CHOP treatments of chemo. I got congestive heart failure from it and could not continue thru the 6th and final chemo. Turns out after a PET scan, ne lymph node in my neck was still there. All others in my body were gone. Now I have started a second, less strong chemo treatment. I was told that if I didn’t take this chemo, I could be dead before Christmas. I’m scared! Do this kind of Cannabis oil work for
lymph node T-Cell??

Carole, I am so sorry to hear about your test results. I can only imagine how scary this must be for you. Please don’t allow your doctor’s words to discourage you. Doctors can make guesses on how long you might live with your condition, but they cannot predict the future. I’ve seen so many that have been flat out wrong over the years. individuals who had 6 months to live but were still around 10 years later. Statistics cannot predict individual outcomes. It’s so important to hold on to hope and faith. Alternative therapies (such as CBD oil) can be used in conjunction with your regular medical treatments but should not be used in place of them. In other words, CBD oil should be viewed as a supplement to your ongoing treatments but should never be considered the treatment itself. Here’s a guide on using Cannabis Oil During Cancer Treatments that should answer most of your questions. As always, we recommend consulting with your doctor before using this product or others. Please know that you are in my thoughts and prayers.

In January 2018 I was diagnosed with stage 2a breast cancer. I was told the tumor was 1.5 to 2 cm in size. My brother had a homemade cannibus oil and I had ordered suppositories. Since I have never use marijuana in any form the suppositories were to be a better option. I started using it in mid January and eating a diet that included lots of carrots, broccoli, eating tomatoes and tomatoe soup and a list of other foods that were to stop the breast cancer cells. My surgery was on Jan. 31st because I wanted the tumor out of me. the pathology report came back and the tumor was .07cmx.08cmx.05cm. one-fourth the size. So what did it? Or were the other two just wrong? Not sure but I am trying a way to get me the CBD oil that I can use on a daily basis.
I would like to know the doses?

I’m so curious to hear what ratio and dosage you took. I was diagnosed with triple positive Stage 1a invasive ductal carcinoma of the left breast 2 weeks ago- no node involvement yet. They want me to do 6 rounds of chemo and Herceptin- type drugs (those for a full year), plus a partial mastectomy after that, plus radiation. I started taking pure CBD before bed but am really interested in using a THC/ CBD blend to help control/ shrink the tumor. I’d so appreciate any advice!

I was diagnosed with HER2 positive breast cancer that was in my lymph nodes. After I started my regimen of weed my scans are clear and I had no bad side affect from chemo. I think marijuana has cured my breast cancer and will stop it from spreading!! I am 33 years old and cancer free!! I am forever grateful to this plant for helping me and giving me more years with my 6 year old daughter!

Hi Brit,
Congratulations on being a survivor! I’m also HER2 positive luckily it didn’t spread. Can you provide more detail what your regimen consists of? I’m very interested but just don’t know how to go about this. Thank you!

Britt,
Could you go into specifics on your Regimen for treatment. How long did it take you to build up to your dose?
Other sources I have found recommend taking an amount equal to a grain of rice 3 times a day and double that every 4 days until you get to 1 gram a day. Then continue for 60 days. If the cancer is gone by then you want to reduce the amount .25 gram and continue to take for a while until you feel like your free.
If you have a medical card in Colorado you can purchase the oil at a dispensary. They sell it for recreational but it’s not strong enough, you need the full FECO. It’s not that hard to make if you have quality flower.

I would like to know more about the CBD oil and THC,what is safe,the best way to take,how much to take and where to purchase safety to receive the right oil.Had breast cancer in 1992 and came back,just had both breast removed 6-1-17 and 4 high doses(two different kinds combined) chemo treatments.In severe pain daily from bone pain(neck,spine,hips,feet,just about every bone in my body.Surgeon I see said I can not have surgery because my back and neck is so bad that I could be paralyzed and he told me not to let anyone operate on it,this is what he specializes in but refuses to operate because of the danger.Just fell and broke my hip in two places(3 months after finishing chemo.I take 10mg of Norco(allowed only 4 within 24 hours,still hurt Day and night.please if there’s something better and safer would rather not take Norco because if I stay up on my feet after taking i still am in bad pain.Tired of not able to do anything just because of so much pain,other wise I could do more.

5hisnisna great topic to discuss and I read all the requests for help from people being diagnosed with various Cancers. In the UK Cannabis oil is still illeagle, but it isn’t in Canada, I would suggest that you visit a Canadian forum as the users there will have more advice on how to administer the oil the best way for you

Also, take a look on you tube under Sacred Plant, it’s American but really interesting.

My theory of why CBD oil cures some diseases is different from others’. Since the pathogen mentioned below can cause all those diseases, and since CBD kills that pathogen (CBD is the plants’ natural defense against that type of microorganism), then that’s how it works.

Some online documents state this cancer-causing, mental illness-inducing airborne pathogen is not zoonotic. That’s wrong! It’s carried and shed by bats in their feces. And healthy people can get it, too.

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My coworkers and I, all immunocompetent, got Disseminated Histoplasmosis from roosting bats, that shed the fungus in their feces. The doctors said we couldn’t possibly have it, since we all had intact immune systems. The doctors were wrong.

More than 100 outbreaks have occurred in the U.S. since 1938, and those are just the ones that were figured out, since people go to different doctors. One outbreak was over 100,000 victims in Indianapolis. 80-90+% of people in some areas have been infected, and it can lay dormant for up to 40 years in the lungs and/or adrenals.

This underdiagnosed airborne infectious disease mimics the flu and can cause malignancies, precancerous conditions, rheumatological diseases, connective tissue diseases, heart disease, autoimmune symptoms, inflammation, adrenal insufficiency, seizures, migraines, hydrocephalus, hallucinations, etc. and is often undiagnosed/misdiagnosed in immunocompetent people.

It’s known to cause hematological malignancies, and doctors claim leukemia patients go into remission when given antifungal. My friend in another state who died from lupus lived across the street from a bat colony. An acquaintance with alopecia universalis and whose mother had degenerative brain disorder has bat houses on their property.

Researchers claim the subacute type is more common than believed. It’s known to at least “mimic” autoimmune diseases and cancer and known to give false-positives in PET scans. But no one diagnosed with an autoimmune disease or cancer is screened for it. In fact, at least one NIH paper states explicitly that all patients diagnosed with sarcoidosis be tested for it, but most, if not all, are not. Other doctors are claiming sarcoidosis IS disseminated histoplasmosis.

What if this infection, that made me and my coworkers so ill, isn’t rare in immunocompetent people? What if just the diagnosis is rare, since most doctors ignore it?

Older documents state people who spend a lot of time in a building with roosting bats, in caves, working as landscapers, construction workers, pest control workers, etc. are known to get Disseminated Histoplasmosis, but the info appears to have been lost, for the most part. And now bat conservationists encourage people to leave bats in buildings/homes. What a terrible mistake they’ve made.

This pathogen parasitizes the reticuloendothelial system/invades macrophages, can infect and affect the lymphatic system and all tissues/organs, causes inflammation, granulomas, and idiopathic (unknown cause) diseases and conditions, including hematological malignancies, autoimmune symptoms, myelitis, myositis, vasculitis, panniculitis, dysplasia, hyperplasia, etc. It causes hypervascularization, calcifications, sclerosis, fibrosis, necrosis, eosinophilia, leukopenia, anemia, neutrophilia, pancytopenia, thrombocytopenia, hypoglycemia, cysts, abscesses, polyps, stenosis, perforations, GI problems, hepatitis, focal neurologic deficits, etc.

Many diseases it might cause are comorbid with other diseases it might cause, for example depression/anxiety/MS linked to Crohn’s.

The fungus is an Oxygenale and therefore consumes collagen. It’s known to cause connective tissue diseases (Myxomatous degeneration?), rheumatological conditions, seizures, and mental illness. Fungal hyphae carry an electrical charge and align under a current. It causes RNA/DNA damage. It’s known to cause delusions, wild mood swings (pseudobulbar affect?), and hallucinations. It’s most potent in female lactating bats, because the fungus likes sugar (lactose) and nitrogen (amino acids, protein, neurotransmitters?), releasing lactase and proteinases to obtain them. What about female lactating humans…postpartum psychosis (and don’t some of these poor women also have trouble swallowing)? The bats give birth late spring/summer, and I noticed suicide rates spike in late spring/early summer. It’s known to cause retinal detachment, and retinal detachments are known to peak around June-July/in hot weather. A map of mental distress and some diseases appear to almost perfectly overlay a map of Histoplasmosis. Johns Hopkins linked autism to an immune response in the womb. Alzheimer’s was linked to hypoglycemia, which can be caused by chronic CNS histoplasmosis. Cancer is known to occur more often near rivers than in mountains or deserts, just like this infection.

The bats eat moths, which are attracted to blue and white city lights that simulate the moon the moths use to navigate. Bats feed up to 500 feet in the air and six miles away in any direction from their roost, but not when it’s raining or when the temperature is less than approximately 56° F. The fungus can grow in bird feces, but birds don’t carry it because their body temperature is too high, killing the fungus.

I believe the “side effects” of Haldol (leukopenia and MS symptoms) might not always be side effects but just more symptoms of Disseminated Histoplasmosis, since it causes leukopenia and MS symptoms. What about the unknown reason why beta receptor blockers cause tardive dyskinesia? The tinnitus, photophobia, psychosis “caused” by Cipro? Hypersexuality and leukemia “caused” by Abilify? Humira linked to lymphoma, leukemia and melanoma in children? Disseminated Histoplasmosis is known to cause enteropathy, so could some people thought to have nonsteroidal anti-inflammatory drug enteropathy have it and taking NSAIDs for the pain/inflammation it causes, and the NSAIDs aren’t the actual culprit?

From my experience, I learned that NO doctor, at least in DFW, will suspect subacute and/or progressive disseminated histoplasmosis in immunocompetent people. Some doctors, at least the ones I went to, will actually REFUSE to test for it, even when told someone and their coworkers have all the symptoms and spend a lot of time in a building with bats in the ceiling. Victims will be accused of hypochondriasis. (My doctors told me only farmer’s get it, it’s only in bird feces, and it only infects the lungs. wrong, wrong, and wrong!) In fact, the first doctor to diagnose me was a pulmonologist, and the only reason he examined me was to try to prove that I didn’t have it, when I really did. No doctor I went to realized bats carry the fungus. And NO doctor I went to in DFW, even infectious disease “experts,” understand the DISSEMINATED form, just the pulmonary form, and the only test that will be done by many doctors before they diagnose people as NOT having it is an X-ray, even though at least 40-70% of victims will have NO sign of it on a lung X-ray. It OFTEN gives false-negatives in lab tests (some people are correctly diagnosed only during an autopsy after obtaining negative test results) and cultures may not show growth until after 6-12 weeks of incubation (but some labs report results after 2 weeks).

One disease of unknown cause that could be caused by Disseminated Histoplasmosis: I suspect, based on my and my coworker’s symptoms (during our “rare” infectious disease outbreak) and my research, that interstitial cystitis and its comorbid conditions can be caused by disseminated histoplasmosis, which causes inflammation throughout the body, causes “autoimmune” symptoms, and is not as rare as believed. I read that “interstitial cystitis (IC) is a chronic inflammatory condition of the submucosal and muscular layers of the bladder, and the cause is currently unknown. Some people with IC have been diagnosed with other conditions such as irritable bowel syndrome (IBS), fibromyalgia, chronic fatigue syndrome, allergies, and Sjogren’s syndrome, which raises the possibility that interstitial cystitis may be caused by mechanisms that cause these other conditions. In addition, men with IC are frequently diagnosed as having chronic nonbacterial prostatitis, and there is an extensive overlap of symptoms and treatment between the two conditions, leading researchers to posit that the conditions may share the same etiology and pathology.” Sounds like Disseminated Histoplasmosis, doesn’t it?

My coworkers and I were always most ill around April/May/June, presumably since the Mexican Free-tail bats gave birth in Texas during May (and the fungus was most potent), and fall/Thanksgiving to December, for some unknown reason (maybe migrating bats from the north?). We had GI problems, liver problems, weird rashes (erythema nodosum, erythema multiforme, erythema marginatum/annulare, etc.), plantar fasciitis, etc., and I had swollen lymph nodes, hives, lesions, abdominal aura, and started getting migraines and plantar fasciitis in the building, and I haven’t had them since I left. It gave me temporary fecal incontinence, seizures, dark blood from my intestines, tinnitus, nystagmus, blurry vision/floaters/flashes of light, benign paroxysmal positional vertigo, isolated diastolic hypertension, what felt like burning skin, various aches and pains (some felt like pin pricks and pinches), tingling, tremors, “explosions” like fireworks in my head while sleeping, and temporary blindness. Suddenly I was allergic to Comice pears (latex fruit allergy or oral allergy syndrome?). I had insomnia (presumably from the fungus acidifying the blood, releasing adrenaline) and parasomnias. It felt like strong bursts of electrical shocks or steady electrical currents in my body, which now feel like low electrical currents at times, mostly at night. I suddenly had symptoms of several inflammatory/autoimmune diseases, including Fibromyalgia, Sarcoidosis, ALS, MS, Sjogren’s syndrome, etc. that have disappeared since leaving the area and taking nothing but Itraconazole antifungal.

No one, including doctors (we all went to different ones), could figure out what was wrong with us, and I was being killed by my doctor, who mistakenly refused to believe I had it and gave me progressively higher and higher doses of Prednisone (2 years after I already had Disseminated Histoplasmosis) after a positive ANA titer, until I miraculously remembered that a visiting man once told my elementary school class that bats CARRY histoplasmosis. So much of it that they evolved to deal with the photophobia and tinnitus it causes by hunting at night by echolocation. There’s a lot more. I wrote a book about my experience with Disseminated Histoplasmosis called “Batsh#t Crazy,” because bats shed the fungus in their feces and it causes delusions and hallucinations, I suspect by the sclerotia fungal mycelia can form emitting hallucinogens (like psilocybin and dimethyltryptamine) along with inflammation in the CNS. (Schizophrenics have 2X of a chemical associated with yeast, part of the fungal life cycle.)

Thank you for your time,

P.S. Doesn’t this infection share all the same symptoms with Gulf War Syndrome?