The effects of iron build up (shown to disrupt mitochondria and potentially cause alzheimer’s disease) can be reduced with cannabidiol (CBD). Newest Cbd Oil And Iron Overload | PIER88 cbd oil works to reduce seizures and is legal Best Usage Best Selling cbd oil and iron overload PIER88. Zhang thc free marijuana Ying, of course, Hemochromatosis is a condition where your body absorbs too much iron. Find out what causes it and what treatments are available.
Study: Cannabidiol (CBD) May Help to Prevent or Treat Neurodegenerative Diseases
With the advances in science, life expectancy is much longer now than it was 100 years ago. While this is a positive thing, it means that more and more people are being affected by neurodegenerative diseases, like Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease.
“Iron is deposited in parts of the body and gradually builds up. Excess iron is linked to various diseases, such as: liver fibrosis, heart attacks, and cancer.”
Unfortunately, there is still a lot that we don’t know about neurodegenerative diseases. Much of what we do know can be attributed to Dr. George Bartzokis.
Knowing that iron builds up in certain parts of our body over time, he investigated the effect iron has on brain development. In his research, he found a link between excess levels of iron and brain degradation, showing that excess iron buildup is responsible for the cognitive deficits associated with certain diseases.
One of the areas where the brain stores iron is the basal ganglia (an area of the brain involved in voluntary movement and habit regulation, among other functions), which is the area that is often associated with diseases like Alzheimer’s and Parkinson’s.
Iron Affects Mitochondria Dynamics, Triggers Cell Death
To best understand the study published in the July 2013 issue of Molecular Neurobiology, it helps to understand the role of mitochondria; they are found in most cells and housed inside of a membrane. Because mitochondria generate most of a cell’s chemical energy, they are often referred to as the “cellular power plant.” It is their job to control cell processes, like apoptosis (or programmed cell death).
One deficit associated with neurodegenerative diseases, like Alzheimer’s and Parkinson’s, is less chemical energy at the synapses (where cells pass signals to each other). This suggests that mitochondria may play a key role in maintaining an efficient circuit of neurons in the brain. The iron seems to disrupt the dynamics of the mitochondria, causing them to initiate more cell death than normal.
CBD May Benefit Alzheimer’s, Parkinson’s Disease Patients
Influenced by past studies, which showed cannabidiol helps recover iron-induced memory deficits, researchers from Pontifical Catholic University in Brazil examined the relationship between CBD and neurodegenerative diseases in this study. They focused on the mitochondria in order to understand how cannabidiol (CBD) helps those suffering from Alzheimer’s and Parkinson’s.
First, the researchers overloaded rats with iron and treated some of them with cannabidiol. They found high levels of dynamin-1-like (DNM1L) and caspase 3, proteins associated with cell death, as a result of excess iron. This gives further proof to the idea that iron disrupts the balance of mitochondria.
“CBD should be considered as a potential molecule with memory-rescuing and neuroprotective properties.” – Pontifical Catholic University researchers
The study found promising results when they examined the effect of cannabidiol. The levels of DNM1L and caspase 3 in the hippocampus returned to the normal levels with CBD treatment. Because those are the proteins associated with cell death, the researchers concluded that CBD may have protected the brain from the rapid cell death associated with iron.
The effects that iron build-up has on the brain is apparent; it is very closely tied to the onset of Alzheimer’s disease, among other neurodegenerative diseases. To this point, our knowledge of how to treat neurodegenerative diseases is sparse, but these findings are promising. More research is certainly necessary, but cannabidiol treatment could prove to be a successful way of preventing brain degradation.
Click here for more information on the potential for cannabinoid medicine use in the prevention/treatment of neurodegenerative diseases.
For information on reasonable expectations and safety in considering whole-plant medical cannabis use, as well as how you can advocate to move cannabis out of the Schedule I controlled substance classification in order to increase research on phytocannabinoids in the United States, click here.
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What Is Hemochromatosis?
Normally, your intestines absorb just the right amount of iron from the foods you eat. But in hemochromatosis, your body absorbs too much, and it has no way to get rid of it. So, your body stores the excess iron in your joints and in organs like your liver, heart, and pancreas. This damages them. If it’s not treated, hemochromatosis can make your organs stop working.
There are two types of this condition — primary and secondary.
Primary hemochromatosis is hereditary, meaning it runs in families. If you get two of the genes that cause it, one from your mother and one from your father, you’ll have a higher risk of getting the disorder.
Secondary hemochromatosis happens because of other conditions you have. These include:
- Certain kinds of anemia disease
- Getting a lot of blood transfusions
White people of northern European descent are more likely to get hereditary hemochromatosis. Men are 5 times more likely to get it than women.
Up to half of people who have hemochromatosis don’t get any symptoms. In men, symptoms tend to show up between ages 30 and 50. Women often don’t show signs of this condition until they’re over 50 or past menopause. That may be because they lose iron when they get their periods and give birth.
Symptoms of hemochromatosis include:
- Pain in your joints, especially your knuckles
- Feeling tired
- Unexplained weight loss that has a bronze or gray color
- Pain in your belly
- Loss of sex drive
- Loss of body hair
- Foggy memory
Sometimes people don’t get any symptoms of hemochromatosis until other problems arise. These may include:
problems, including cirrhosis (scarring) of the liver
- Abnormal heartbeat (trouble having an erection)
If you take a lot of vitamin C or eat a lot of foods that contain it, you can make hemochromatosis worse. That’s because vitamin C helps your body absorb iron from food.
It can be tricky for your doctor to diagnose hemochromatosis, because other conditions have the same symptoms. They might want you to get tested if:
- You’re having symptoms.
- You have one of the problems listed above.
- A family member has the disorder.
There are some other ways your doctor can figure out if you have it:
Checking your history. They’ll ask about your family and if anyone has hemochromatosis or signs of it. They might also ask about things like arthritis and liver disease, which might mean you or someone in your family has hemochromatosis but doesn’t know it.
Physical exam. Your doctor will examine your body. This involves using a stethoscope to listen to what’s going on inside. They might also tap on different parts of your body.
Blood tests. Two tests can give your doctor a clue about hemochromatosis:
- Transferrin saturation. This shows how much iron is stuck to transferrin, a protein that carries iron in your blood.
- Serum ferritin. This test measures the amount of ferritin, a protein that stores iron, in your blood.
If either of these shows you have more iron than you should, your doctor might order a third test to see if you have a gene that causes hemochromatosis.
Liver biopsy. Your doctor will take a small piece of your liver. They’ll look at it under a microscope to see if there’s any liver damage.
MRI. This is a scan that uses magnets and radio waves to take a picture of your organs.
If you have primary hemochromatosis, doctors treat it by removing blood from your body on a regular basis. It’s a lot like donating blood. Your doctor will insert a needle into a vein in your arm or leg. The blood flows through the needle and into a tube that’s attached to a bag.
The goal is to remove some of your blood so that your iron levels return to normal. This could take up to a year or more. Blood removal is divided into two parts: initial treatment and maintenance treatment.
Initial treatment. You’ll visit your doctor’s office or a hospital once or twice a week to have your blood drawn. You may have up to a pint taken at a time.
Maintenance treatment. Once your blood iron levels have gone back to normal, you’ll still have to have to have blood taken, but not as often. It’ll be based on how fast iron builds back up in your body.
Cleveland Clinic: “Hemochromatosis.”
National Heart, Lung, and Blood Institute: “What Is Hemochromatosis?”
American Academy of Family Physicians (familydoctor.org): “Hereditary Hemochromatosis.”
National Institute of Diabetes and Digestive and Kidney Diseases: “Hemochromatosis.”