CBD Oil And Prozac Interaction Dogs

This article will show you how CBD may be used as an alternative to fluoxetine, and that it may be beneficial in helping canine depression, fear aggression, anxiety, separation anxiety, and more! Looking for an easy way to wean your dog off medications? CBD oil might help you in this endeavor. CBD and fluoxetine are both used to treat clinical depression. Are they safe to use together? What are the risks? Learn about the potential dangers.

CBD as an Alternative to Fluoxetine

Recognizing the symptoms of anxiety, fear, stress, and depression will help you keep your dog happy and relaxed. Understanding the symptoms allows us to intervene at an earlier stage, and to address these problems with veterinarians and behaviorists.

This article will show you how CBD may be used as an alternative to fluoxetine, and that it may be beneficial in helping canine depression, fear aggression, anxiety, separation anxiety, and more! That said, combining both CBD and doggie Prozac may depress the cardiac/respiratory system, and you’ll need to consult with your veterinarian before doing so.

Dogs don’t grow out of fear or depression. You’ll need to step in and help! The first thing to know is that you’ll need to make use of multi modal approaches and begin by helping your furry best friend relax.

Behavior modification, counter conditioning, as well as desensitization help will fear, but when your pooch is depressed, your veterinarian may recommend fluoxetine or doggie Prozac to help. This has proven to be very helpful with depression, and other behavioral issues in dogs.

That said, today CBD is trending as a natural supplement. Cannabinoids interact with the endocannabinoid receptors in dogs, which in turn helps to maintain homeostasis. If you’re considering using CBD on your dog instead of fluoxetine, you’ll need to consult with your veterinarian first for the best advice!

According to Veterinary Practice News , “Fluoxetine is a selective serotonin re-uptake inhibitor (SSRI). That is to say, it delays re-absorption of serotonin into presynaptic nerve endings following its release by blocking the reuptake mechanism. This causes serotonin to persist for longer and thus enhances its effects,” Dr. Nicholas Dodman, BVMS, Dipl. ACVB , via Veterinary Practice News.

Dr. Dodman also goes on to add that fluoxetine also has two other actions. “Two other actions of fluoxetine, as opposed to other SSRIs, are that it is a potent 5-HT2C antagonist and a sigma-1 receptor agonist. Overactivity of 5-HT2C contributes to anxiety and depression so antagonism of these receptors may be advantageous. The sigma receptor agonist action may also be beneficial in some instances in producing antidepressant-like effects.”

“Another purported action of fluoxetine and other SSRIs is to stimulate neurogenesis (maturation of progenitor neurons) in the dentate gyrus of the hippocampus. In this way, SSRIs may act like Miracle-Gro for the brain. This effect takes time and may be responsible for the longish delay before SSRIs attain their peak effects.”

What Is It Used for?

Did you know that fluoxetine is prescribed for dogs for a variety of behavior problems? These include the following:

How to Wean Your Dog Off Medications Using CBD Oil

If so, you may have heard about some dog parents replacing their pet’s prescription drugs with CBD.

Well, it’s possible — although it requires veterinary supervision and a lot of knowledge on your part.

In this article, I elaborate on using the best CBD oil to wean your dog off their medication.

Does CBD Interact with Medications?

While CBD is a natural and safe substance, it can compete with other drugs in your body.

That’s because CBD is an inhibitor of specific liver enzymes that metabolize most pharmaceutical medications.

These enzymes are called cytochrome P450 and help break down around 60% of all the medications available on the market.

This includes antidepressants, anticonvulsants, analgesics, NSAIDs, etc.

Research has shown that CBD can block the activity of these enzymes, slowing down the metabolic rate of other medications.

As a result, the medications stay in the body for longer, and in larger concentrations.

CBD’s impact on these metabolic enzymes depends on dosage as well as the presence of any other drugs in the body.

The most alarming side effect of these interactions is the higher incidence of adverse reactions from the elevated levels of medications in the body.

For more detailed information about interactions between CBD and pharmaceutical substances, check out the Flockhart P450 Drug Information Table.

Can You Give Your Dog CBD Alongside Other Drugs and Supplements?

This question requires more than a simple answer.

CBD is considered a safe supplement and is commonly used together with other supplements and medications.

As a matter of fact, some studies found that cannabinoids could help increase the efficacy of some medications, such as painkillers.

The paper from the 2016 Journal of Opioid Management describes the synergism of cannabinoids with other pain medications.

Now, considering that CBD can bolster the effects of other drugs — it can be both positive and troublesome.

For example, studies have shown that cannabinoids have the potential to increase the potency of opioid medications — leading researchers to a conclusion that CBD helps lower opioid doses in patients. This could slowly help them wean off their current medication and reduce dependence on pharmaceutical drugs.

The problematic part of this feature involves the aforementioned risk of second-hand side effects that come from these medications when you take them alongside CBD.

For now, there’s a limited body of evidence that examined specifically how CBD interferes with the effects of other drugs.

Even fewer studies have been conducted on these interactions when it comes to veterinary drugs.

Therefore, the first step you should take before using CBD to wean your dog off its medication is to consult your vet.

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Or look for one that specializes in holistic treatments if your vet doesn’t know much about CBD.

How CBD May Affect the Potency of Other Drugs and Supplements

Before I continue to elaborate on weaning your dog off its regular medications, let’s take a closer look at how CBD may affect the potency of pharmaceutical medications.

This is a paramount aspect of this article because some medications like anticonvulsants, antidepressants, or chemotherapy, are often prescribed at very specific doses.

For example, when treating dogs with cancer, veterinarians often take a lot of time to figure out the right dosage of their chemo treatment.

The dose should be strong enough to effectively target cancer, yet small enough to avoid toxicity and minimize the side effects.

These drugs are, as you may guess, metabolized by cytochrome P450 enzymes in the liver.

Given this, using CBD alongside chemotherapy could be risky because it may elevate the levels of these drugs in your dog’s blood.

In other words, what would be a safe dose of chemo could, potentially, become threatening when used together with CBD.

The reality is that CBD is becoming more popular among different kinds of patients due to its versatility as a therapeutic compound.

These patients find that CBD improves their quality of life by helping them maintain a healthy appetite, reduce fatigue and lethargy, curb nausea, manage pain, and more.

There’s very little evidence that shows interactions between CBD and chemotherapy agents — despite these experimental lab models.

My Rocky has age-related arthritis and before I started giving him CBD oil for dogs with arthritis, he was very lethargic and became dependent on his medications.

After seeing his condition deteriorating, I gave CBD the leap of faith because it was helping with my knee pain too. Considering that dogs have the endocannabinoid system as well, my decision seemed reasonable to me.

And it was actually the best decision I could make at that time. I consulted my vet and we slowly started changing the doses of CBD oil and Rocky’s meds — gradually weaning him off of his pharmaceuticals.

Don’t get me wrong, I’m not encouraging you to leave your dog’s current medications away. It’s just an option that you may want to consult with your vet if the risks and side effects start to outweigh the benefits.

When is it Time to Wean Your Dog Off Their Medication?

That’s a question many pet owners ask. The answer is not so obvious and depends on a lot of individual factors, such as your dog’s condition, tolerance to the medication they’re taking, and their current results.

Ask your vet how these medications are processed in the body and whether taking into account CBD’s effect on liver enzymes, there’s a risk of an interaction.

Also, make sure to check the P450 Flockhart Drug Interactions Chart and look for the dog your dog is taking to confirm if the interaction might occur.

If your dog’s meds aren’t on this list, still reach out to your vet before adding CBD to its diet.

Should there be a possibility of drug interaction, I’d suggest weaning your dog pet off their meds first.

In case the drugs weren’t on the above list, you may use CBD together with their regular medicines.

From there, you can begin to wean your dog off their other meds steadily.

5 Ways You Can Replace Your Dog’s Prescription Meds with CBD

There are a few things you can do to incorporate CBD as smoothly as possible.

Here’s what I recommend:

  1. Consult your vet
  2. Make sure that CBD is appropriate for the specific condition
  3. Start with low doses
  4. Slowly increase the CBD dose while cutting down on the medication dose
  5. Don’t rush anything

Let me elaborate on each step.

1. Consult Your Veterinarian

Before you introduce anything new to your dog’s supplementation plan, talk to your vet about the potential benefits of CBD as well as the risk of a drug interaction. If there’s a possibility CBD might affect the way your pet’s body processes other medication, you should figure out how it happens and what you can do to avoid negative reactions while using both.

2. Learn About the Health Benefits of CBD for Dogs

Once you know there’s no risk of negative drug interaction and that CBD can replace your dog’s medications, you can give it a green light. Just remember that CBD is no miracle cure and can’t replace any medication out there despite its versatility.

3. Find the Right CBD Dosage for Your Dog

Make the transition to CBD slowly and don’t rush large doses. Observe your pet’s reaction to certain amounts of the supplements. Start low and increase the dose slowly; you can break it down into two smaller daily doses.

Reputable companies provide clear instructions on dosage and serving sizes for dogs based on different weight groups to help new users introduce CBD to dogs safely.

4. Establish the Right Routine for CBD and Medication

Once your dog has adjusted to CBD, you can start increasing the dose while decreasing the dose of their other medications.

Just make sure to monitor the doses of CBD and the meds because certain medications can have dangerous side effects if there’s an excess concentration in the body. Your vet should know how to manage the dosages safely.

5. Take this Process Easy

Being patient will help you go through the transition process smoothly. Weaning your dog off its medications can be a process lasting weeks or even months. Remember, the way you do it will also vary depending on how long your dog has been on its meds, the dose it has been taking, and the half-life of the substance.

Unfortunately, I can’t give you any recommendations as to how to reduce your dog’s drug doses; that’s the job of your veterinarian, they should be qualified enough to help you out.

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Medications that Can Be Replaced with CBD

Thanks to its broad range of health benefits, CBD could replace a lot of regular pet medications.

The list is quite long and includes:

  • Tramadol
  • Antihistamines
  • Carprofen
  • Steroids
  • Metacam
  • Rimadyl
  • Phenobarbital
  • Antifungals
  • Anxiolytics
  • Prozac
  • Gabapentin
  • Maropitant
  • Mirtazapine
  • Oxymorphone

The Benefits of Weaning Off Your Dog’s Medication with CBD

Just so we’re on the same page: I’m not the enemy of all prescription medications. I always try to see the bright side in both natural and made-man medications because I understand their value.

But, I also believe that natural remedies can offer your pet a lot of health benefits and are generally safer than their pharmaceutical counterparts.

CBD is completely natural; it also produces no dangerous side effects and is non-toxic — so you don’t have to be afraid about overdosing.

The only real side effects your dog can experience after taking too much CBD are sedation and diarrhea. It may feel sleepy and drowsy for a while, but this isn’t a threat to its health.

That stays in vivid contrast with the harsh side effects (sometimes even fatal) that can occur when a drug isn’t administered properly.

Plus, unlike conventional medications, CBD uses more than just a single mechanism to improve your dog’s well-being.

It’s a well-rounded health supplement that can also have direct therapeutic effects.

Best CBD Oil for Dogs: Royal CBD

As I said, I started giving Rocky CBD oil after experiencing its benefits first-hand. Royal CBD has been my go-to brand, and after experimenting with different companies to find the right pet product, the guys at Royal CBD introduced its “Paws” collection.

The Royal CBD pet range includes CBD oil for pet dogs in two concentrations and three formulas of CBD dog treats formulated with superfoods.

The CBD oil is available in 250 mg and 500 mg bottles and comes in a bacon flavor to convince the fussier dogs to take it properly.

The treats include three versions:

  • Active: with cinnamon and pumpkin spice
  • Hearty: with potato and blueberry
  • Calm: with peanut butter and apple

Royal CBD products are made from US-grown, non-GMO hemp. They’re also tested for potency and purity in an ISO-certified laboratory so that you can rest assured your dog eats only safe products.

Final Thoughts on CBD as a Way to Wean Your Dog Off Medications

My dog medicine cabinet has become a lot smaller since I introduced CBD into Rocky’s routine.

If you’re curious about the potential health benefits of CBD oil for your dog and want to use it to wean it off its current medications, make sure to save this article for later and use it as a guide to a safe transition.

Most importantly, always consult your veterinarian before introducing a new supplement; and be that informed customer who doesn’t fall for outlandish health claims and inch-deep marketing phrases from companies that sell snake oil all over the internet.

Check out my other CBD reviews and rankings to see a bigger picture and pick out some high-quality suppliers for yourself.

Nina Julia

Nina created CFAH.org following the birth of her second child. She was a science and math teacher for 6 years prior to becoming a parent — teaching in schools in White Plains, New York and later in Paterson, New Jersey.

Does CBD Interact With Fluoxetine (Prozac)?

Fluoxetine (Prozac), is a common prescription SSRI medication used in the treatment of anxiety and depression.

There’s a moderate risk of CBD interacting with fluoxetine.

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According to the CDC, roughly 13% of the population takes antidepressant medications. Another survey found that nearly 14% of the population takes CBD .

Unsurprisingly, there are a lot of people who take both CBD (cannabidiol) and SSRIs at the same time.

Is this combination safe? Are there any dangers to be aware of? We’ll explore the potential risks and interactions when combining CBD with fluoxetine (Prozac).

Table of Contents
  • Does CBD Interact With Fluoxetine (Prozac)?
  • Precautions While Taking Fluoxetine

Does CBD Interact With Fluoxetine (Prozac)?

There is a moderate risk of increased side effects when using CBD with antidepressants such as fluoxetine (Prozac) [1].

The chances of users experiencing a serious interaction are low. However, some of the rare but possible side effects are severe — including seizures and serotonin syndrome.

There are two main ways CBD can interact with fluoxetine.

Interaction 1: Slowed Elimination (Metabolic Inhibition)

CBD strongly interacts with other drugs metabolized by CYP2C19 and moderately interacts with drugs metabolized by CYP2D6 [2].

Most SSRIs, including fluoxetine, are also metabolized by CYP2D6 [3]. Fluoxetine is a moderate inhibitor of drugs metabolized by CYP2D6 but a strong inhibitor of drugs metabolized by CYP2C19.

Since CBD and fluoxetine compete for metabolism in the liver, serum levels of both compounds can elevate. This slows fluoxetine’s metabolization, which, in turn, increases the possibility of side effects.

Adverse effects from mixing CBD with fluoxetine include nausea, diarrhea, and headaches.

Interaction 2: Increased Effect (Agonistic Interaction)

Simultaneously taking two substances with similar actions results in an agonistic interaction. CBD and fluoxetine may compound each other’s actions as they are both used to treat depression, anxiety, and panic disorders.

This interaction can result in serious side effects.

Therefore, before taking CBD and fluoxetine together, you must consult with your physician first. They may want to reduce your dose of Prozac or advise you to separate your dose of SSRIs and CBD by about 2-hours to minimize your risk.

Other Names for Fluoxetine

Fluoxetine is a generic drug marketed under many different brand names. All of the following medicines share the same risk and potential for interaction with CBD.

Some of the other names for fluoxetine are:

  • Prozac
  • Sarafem
  • Rapiflux
  • Selfemra
  • Fludac
  • Fludep
  • Flugen
  • Fluoxee
  • Flutrac
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Similar Medications

Fluoxetine (Prozac) is classified as an SSRI drug. CBD and SSRIs interact and share the same risks.

  • Fluvoxamine (Luvox, Faverin, Fluvoxin, Boxamine, Fluvator)
  • Paroxetine (Aropax, Paxil, Pexeva, Seroxat, Sereupin, Brisdelle)
  • Sertraline (Zoloft, Lustral, Actiser, Dazolin, Depsert, Insert, Mares)
  • Citalopram (Celexa, Cipramil, C-pram, Celepra, Celica, Cipam, Citalent, Citalomine)
  • Escitalopram (Lexapro, Alwel, Anipram, Rhopram S, Talo, Szetalo, Stalopam, S Celepra)
  • Dapoxetine (Priligy, Dasutra, Duralast, Kutub, Dapox, Ejalong, Prilyxet, Xydap)

Is It Safe to Take CBD & Fluoxetine (Prozac) Together?

Safety concerns with the co-administration of CBD and fluoxetine (Prozac) are still a topic of debate. Few studies exist on potential drug interactions between these two substances.

CBD and fluoxetine, when taken together, may lead to some undesirable side effects such as dizziness, drowsiness, difficulty in concentrating, and confusion. Older individuals may experience impairment in motor coordination along with judgment and thinking.

A lower dosage of fluoxetine, when taken with CBD, may have fewer side effects than higher dosages. However, it’s best to avoid the co-administration of CBD and fluoxetine.

Consult your doctor before you combine CBD with any other medication, including fluoxetine.

Is CBD a Viable Alternative to Fluoxetine (Prozac)?

CBD could be a natural alternative in treating depression, substituting fluoxetine due to its similar effects, but it depends on what fluoxetine is prescribed for [4]. If it’s for anything other than mild depression, CBD is unlikely to help. It appears to be better tolerated than routine psychiatric medications [5].

According to the WHO, there have been no reports of a lethal overdose with CBD, and it has an exceedingly low potential for abuse or dependency [6].

CBD has a low overall risk of side effects with short-term use compared to most antipsychotics. However, further research is needed to evaluate possible long-term dangers and damages.

However, do not stop taking fluoxetine or adjust the dose as it can lead to withdrawal symptoms. Always consult your physician first before switching between drugs or supplementing prescribed antidepressants with CBD.

What Is Fluoxetine (Prozac)?

Fluoxetine (Prozac) is a prescription-only medication belonging to the selective serotonin reuptake inhibitor (SSRI) class of antidepressants. It is a generic drug with trade names such as Prozac, Rapiflux, Sarafem, Barazac, and Selfemra.

It’s the drug of choice in treating obsessive-compulsive disorders, panic disorders, social phobias, eating disorders, premenstrual dysphoric disorder, and post-traumatic stress disorder.

These drugs also treat anxiety and bipolar disorders, body dysmorphic disorder, compulsive buying, kleptomania, and premature ejaculation.

It’s for use in children seven years or older only and is available in dosages of 10 mg, 20 mg, 40 mg, and 90 mg capsules.

Fluoxetine Specs

Drug name Fluoxetine
Trade Names Prozac, Rapiflux, Sarafem, Barazac, Selfemra, etc
Classification Selective Serotonin Reuptake Inhibitor (SSRI)
CYP Metabolism Metabolized by CYP2C19 and CYP2D6
Interaction with CBD Metabolic Inhibitor and Agonistic Interaction
Risk of interaction Moderate

What Does Fluoxetine Do?

Fluoxetine (Prozac), belonging to the SSRI class of drugs, blocks serotonin’s reabsorption (reuptake) into neurons.

This leads to increased levels of serotonin in the brain. SSRIs mainly affect serotonin, not other neurotransmitters. Serotonin, famously known as the happy hormone, stabilizes our mood, feelings of well-being, and happiness.

Side Effects of Fluoxetine

  • Rash
  • Sweating
  • Altered appetite and weight
  • Insomnia
  • Nervousness
  • Anxiety
  • Abnormal dreams
  • Weakness
  • Flu-like syndrome
  • Nausea
  • Diarrhea

The following are serious side effects that need immediate medical attention. Call your healthcare provider right away if you have any of these symptoms.

  • Allergic reactions and rash
  • Seizures
  • Abnormal bleeding
  • Potential for cognitive and motor impairment
  • Suicidal thoughts and behaviors in children, adolescents, and young adults under twenty-five years of age
  • Serotonin syndrome (change in mental status, overactive reflexes, fever)

Precautions While Taking Fluoxetine

Besides side effects, there are other things to be aware of if you’re using fluoxetine.

Concomitant Use With Alcohol

Do not mix CBD or fluoxetine with alcohol. The adverse effects of both substances may be fatal when taken with alcohol.

Use With Other Medication

Do not use fluoxetine if you have previously used monoamine oxidases (MAO) inhibitors such as phenelzine and tranylcypromine. It may lead to a condition known as serotonin syndrome, which is life-threatening.

Other drugs that increase serotonin levels include tricyclic antidepressants (TCA), triptans, amphetamine, methamphetamine, MDMA, buspirone, and serotonin-norepinephrine reuptake inhibitors.

Patients using blood-thinning medications should also avoid fluoxetine.


Opioids like pethidine, tramadol, dextromethorphan, and tapentadol will increase serotonergic activity. Fentanyl and methadone have similar effects but to a lesser degree.

A combination of opioids and fluoxetine may increase the risk of serotonin toxicity. Fluoxetine also blocks the metabolism of opioids leading to reduced analgesic effects [7].

Use In Pregnancy

Fluoxetine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus (Pregnancy Category C). It is not for use in breastfeeding women as fluoxetine is excreted in breast milk.

Dose Adjustments

Dose adjustments are required in patients with liver cirrhosis; these patients need lower or less frequent dosing. Unlike other drugs, dose adjustment for fluoxetine is not necessary for patients with impaired renal functions.


Do not stop fluoxetine without talking to your healthcare provider. Stopping the drug suddenly may cause serious withdrawal symptoms such as anxiety, irritability, high or low mood, feeling restless, or changes in sleep habits. Other symptoms include headache, sweating, nausea, dizziness, electric shock-like sensations, shaking, and confusion.

Key Takeaways: Is It Safe to Take Fluoxetine (Prozac) With CBD?

CBD is a natural, relatively nontoxic chemical with antidepressant action. There is a moderate risk if you use CBD and fluoxetine (Prozac) together.

Adverse effects of co-administration include dizziness, drowsiness, difficulty in concentrating, and confusion.

Always consult with your healthcare provider to ensure that CBD does not interact with any medication you are currently taking.