Your complete guide to all things CBD and ADHD, according to the experts. CBD may interact antagonistically with lisdexamfetamine (Vyvanse), a stimulant, and cause side effects. Find out if they’re safe to use together. Hey everyone! I have a 9 year old son with ADHD, and he takes 20 mg of Vyvanse each morning. It is working very well for him, but he is metabolizing through it very quickly, and it is out of his…
Can CBD help with ADHD symptoms?
Your complete guide to all things CBD and ADHD, according to the experts.
Disclaimer: you should always talk to your physician or pharmacist before trying anything new that may affect your health (substances, medication). This guide is simply for reference, and is NOT intended to be a substitution for professional medical advice. Additionally, please note that this article was written from the perspective of a USA citizen. Please check with your local cannabis laws for more information on CBD products in your area.
So, CBD is having a moment.
It’s on Instagram ads, I hear it on podcasts. even my local grocery store sells CBD products! But what the heck is CBD? And can it treat or help with ADHD symptoms?
This CBD + ADHD guide is here to give you the scoop.
Everything you need to know about CBD
What does CBD stand for?
CBD stands for cannabidiol, an active ingredient in the marijuana plant. It’s typically made from hemp, a non-intoxicating variety of cannabis. Unlike the main active ingredient in marijuana, THC (Tetrahydrocannabinol), CBD is non-psychoactive, which means it doesn’t get you high. It’s perhaps best known for treating pain and anxiety.
How do you take CBD?
Cannabidiol oil is available in a variety of forms:
- Ingestion: eating products containing CBD oil, such as gummies, candies, or tinctures
- Sublingual: putting the oil underneath your tongue
- Inhalation: smoking hemp or marijuana with high CBD content
- Topical: applying CBD lotions to your skin
If and when you decide to purchase CBD, make sure you know exactly what you’re buying. Some CBD products also contain THC, which means it can have psychoactive effects. As a general rule, cannabis products with a ratio on their packaging (1:1, 20:1, etc.) contain both compounds. The first number is CBD and the second is THC. So, a 1:1 ratio means the product contains equal amounts of THC and CBD.
CBD and ADHD
The above section was great and all, but how does CBD affect ADHD?
Oh right. That is indeed the point of this article!
In all honesty, the jury is still out. Much of the medically-reviewed research covers general marijuana use, and not cannabidiol specifically.
A 2017 clinical data review published in Cannabis and Cannabinoid Research found promising positive effects of the compound. This review confirmed that cannabidiol is indeed safe, with fewer adverse side effects than comparable medications. Though the review focused on epilepsy and psychosis, the safety and efficacy findings can apply to all uses.
A 2014 study compared the executive functioning of neurotypical adults versus those with ADHD who had or had not recently used cannabis. (Keep in mind that this study was about general cannabis, and didn’t specifically look at CBD by itself.) The study concluded that while ADHDers scored lower on executive functioning than those without ADHD (duh, you already knew that), cannabis did not have a significant effect on that functioning.
Does cannabis make ADHD symptoms worse?
While the data can’t speak for everyone, the 2014 study mentioned above did answer this question with a resounding “no”. However, researchers found that early cannabis use (before age 16) can reduce the capacity for executive functioning, but more research needs to be done in order to determine specifics.
So, does cannabis improve ADHD symptoms?
Now, hold on — I didn’t say that! Let’s look at another study that was inspired by ADHDers who self-medicate with cannabis. Researchers investigated possible benefits of cannabis for ADHD and published their findings in European Neuropsychopharmacology. Again, this study wasn’t CBD-specific, but instead investigated general cannabis use. The results of the small study (30 participants) ranged from positive to neutral. ADHDers using cannabis scored slightly better on cognitive performance and activity levels than the placebo group.
Participants also demonstrated small but promising improvements in:
- Impulsive behaviors
Research estimates that 25-50% of ADHDers have an anxiety disorder; lucky for us, there’s some evidence that cannabidiol can relieve anxiety. Some people with ADHD praise CBD for its ability to calm their racing anxious minds, which allows them to relax and focus.
You can find resources on using CBD for anxiety relief here and here.
CBD side effects
Cannabidiol is generally considered safe, but some users report undesired side effects, such as:
- Dry mouth
- Feeling lightheaded
In rare instances, CBD can cause liver damage. Because of this, you should proceed with extreme caution if you have liver disease, risk factors for liver disease, or are taking medication that can cause liver problems.
CBD’s interactions with medications
General medication interactions
If you take prescription medications, check with your doctor or pharmacist before trying CBD. It’s always good to consult with your doctor, but I’m also empathetic to fears about being labeled a “drug user” or being otherwise judged by physicians for taking CBD. If you have a good relationship with and trust your doctor, I recommend full honesty.
It’s also important to remember that cannabis products aren’t strictly regulated the same way prescription drugs are. You should only purchase products from trusted, vetted, authorized retailers. Here are some common prescription drugs that can potentially interact with CBD. Note that this list isn’t exhaustive and to ask a professional about drug interactions.
Some drugs known to interact with CBD:
- Warfarin: commonly prescribed blood thinner
- Amiodarone: heart rhythm medication
- Levothyroxine: thyroid medication
- Seizure medication: valproate, clobazam, lamotrigine
- Blood pressure drugs: large doses of cannabidiol may interact
- Metformin and heartburn drugs like Prilosec: increase risk of diarrhea
ADHD medication interactions
Unfortunately, there isn’t a ton of research on the interaction with ADHD medications. I found at least one source that said CBD may worsen the decreased appetite that’s common when taking stimulants. There also appears to be a small risk of decreasing the effectiveness of your ADHD medication when taking cannabidiol.
One major caveat to keep in mind is the grapefruit rule: if your medication interacts with grapefruit, you shouldn’t take CBD with it. Here’s a resource about cannabidiol and medications that interact with grapefruit, but you should check if your specific medication brands apply to the grapefruit rule. Additionally, I found some positive interactions between CBD and stimulants, including reduced muscle tension and anxiety. To read more about CBD and ADHD, check out this resource.
Below is everything we could find on common ADHD meds (both stimulant and nonstimulant) and their potential for CBD interaction. This list isn’t comprehensive. We’re always learning new information about this topic, so make sure you’re up to date with current protocols.
- Adderall: Potential appetite loss and reduced efficacy
- Ritalin: Potential interactions at extremely high CBD doses (hundreds to thousands of milligrams); common therapeutic doses are well below this threshold
- Dexedrine: Potential appetite loss and reduced efficacy
- Concerta, Vyvanse: Cannabidiol may prevent proper processing of meds and decrease efficacy
- Wellbutrin: Potential interaction; extent unknown. CBD might increase Wellbutrin’s side effects and/or decrease effectiveness
Is CBD legal?
To paraphrase The Simpsons’ Reverend Lovejoy, “Short answer yes, with an if; long answer no, with a but.”
Federally, all cannabis products are illegal and CBD isn’t FDA-approved (Food and Drug Administration). But 36 states have legalized medical marijuana, and many others legalized recreational use. If you’re in one of those states, CBD is indeed legal and available at dispensaries and other authorized retailers. CBD can be derived from either hemp or marijuana.
Hemp is legal in all states because federal law requires hemp products contain less than 0.3% THC. If marijuana (medical or recreational) is not legal where you live, then products made directly from marijuana are also illegal.
If you’re outside of the USA, I suggest looking up your local marijuana laws.
So, should you try treating your ADHD with CBD?
First, I want to remind you that I’m not a doctor – simply a woman with ADHD who did a bunch of research about CBD.
As suggested above, you should always check with your doctor before starting any new substance or medication. You could even send them the studies I linked above so you’re both on the same page about current research. Let’s say you’ve talked to your doc and they approve of you trying CBD. So — should you go for it? That depends on several things.
I take CBD daily for chronic pain; the pain relief helps me focus on work instead of my pain. So in that way, it benefits my ADHD. However, I can’t say CBD specifically helps ADHD-related behaviors. It doesn’t make my symptoms worse, but it’s not a go-to for treatment. Of course, this is just one person’s experience and shouldn’t influence your own health decisions! But as a daily user, I’d be remiss if I didn’t acknowledge that.
Here are some circumstance where I think it’d be safe to try CBD:
- It’s legal where you live and easy to obtain
- You’ve had previous positive experiences with cannabis
- Your doctor approves
. and some instances where I think you should not try CBD:
- CBD isn’t legal for recreational use in your state or country
- You have liver disease or are at risk for liver disease
- You’ve had previous adverse experiences with cannabis or CBD
- Your doctor advised against it for health reasons
I hope this humble ADHD and CBD guide has given you some answers and helpful info. Whether you’re already a CBD aficionado, are curious to try it, or know it’s not for you, I hope you find some relief — from CBD or from whatever works for you.
Looking for support?
Inflow can help you thrive with ADHD and reach your full potential. Start your journey now by taking our quiz.
Ash Fisher is a Portland-based writer, performer and corgi mom. Check out her writing at ashfisherhaha.com.
Does CBD Interact With Lisdexamfetamine (Vyvanse)?
CBD may interact antagonistically with lisdexamfetamine (Vyvanse), a stimulant, and cause side effects.
The risk of this interaction is mild to moderate.
Lisdexamfetamine (Vyvanse) is a neuro-stimulant used to treat attention deficit hyperactivity disorder (ADHD) and binge eating disorder. It belongs to the amphetamine family of drugs.
Cannabidiol or CBD , a cannabinoid with many health-promoting properties, may behave antagonistically with or slow down the metabolism of lisdexamfetamine and cause side effects.
Are the two safe to take together?
Table of Contents
Does CBD Interact With Lisdexamfetamine (Vyvanse)?
Yes, CBD is likely to interact with Vyvanse — however, the severity of this interaction is low and unlikely to result in any lasting side effects.
There are two primary ways CBD can interact with stimulant drugs like lisdexamfetamine (Vyvanse).
1. Decreased Effects (Antagonistic Interaction)
CBD may counteract some of the stimulating effects of Vyvanse — preventing it from doing its job effectively.
Antagonistic interaction occurs when two drugs act in opposite ways. If taken together, one drug could interfere and even stop the actions of the other drug, causing the second drug to become less effective.
Lisdexamfetamine is a stimulant drug that enhances brain activities such as awareness, wakefulness, emotional regulation, attention, learning, and memory.
In contrast, CBD is a neuromodulator that exerts its effects on the central nervous system (CNS) via multiple pathways that are not yet fully understood. CBD is used as an anticonvulsant and anxiolytic. These effects may happen through its actions on endogenous systems such as neuronal inhibition and intracellular calcium modulation.
Because of their opposite effects, they are likely to cancel each other out, and CBD may reduce the activity and efficacy of lisdexamfetamine.
2. Slowed Elimination (Metabolic Inhibitor)
CBD may interfere with the body’s ability to metabolize Vyvanse — leading to elevated levels. This could lead to an increased risk of side effects from the medication.
Drugs are metabolized in the body due to the actions of the cytochrome P450 class of enzymes. When two medications that need similar enzymes for metabolism are taken together, they compete for the enzyme. This action could result in slowing down the metabolism of both drugs.
Lisdexamfetamine is extensively metabolized and eliminated by the CYP2D6 enzyme. While CYP2D6 also metabolizes CBD, CYP3A4 is the major enzyme responsible for its metabolism. However, CBD has inhibitory effects on CYP2D6, which can slow down the metabolism of lisdexamfetamine. This could cause lisdexamfetamine to accumulate within the body and cause unintentional side effects.
Other Names for Lisdexamfetamine
Lisdexamfetamine is sold under different names. All of them have the same base ingredient and have similar possible interactions.
Other names for lisdexamfetamine include:
Similar Medications: CBD & Stimulants
Lisdexamfetamine (Vyvanse) is a stimulant. CBD and stimulants all share similar risks for interaction and side effects.
Some of the medications that share similar risks when combined with CBD are:
- Amphetamine (Adderall, Adzenys ER, Mydayis)
- DextroamphetamineSulfate (Zenzedi, Dexedrine)
- Methylphenidate (Ritalin)
- Atomoxetine (Strattera)
- Modafinil (Provigil, Nuvigil)
Is It Safe to Take CBD & Lisdexamfetamine (Vyvanse) Together?
Yes, CBD is unlikely to pose any danger when taken with Vyvanse (when used in responsible doses).
However, CBD may negate some of the beneficial effects of the drug, causing it to be insufficient for managing the symptoms it was prescribed for.
Because the conditions Vyvanse is used to treat aren’t life-threatening, there’s a low chance of this effect resulting in any serious consequences.
The main indication for lisdexamfetamine is ADHD, and taking the two drugs together may make symptoms of ADHD worse due to decreased efficacy of lisdexamfetamine.
Always consult your prescribing physician first before you start these drugs, and never adjust the dose or stop taking Vyvanse on your own.
Is CBD a Viable Alternative to Lisdexamfetamine (Vyvanse)?
CBD is not considered a viable alternative to lisdexamfetamine (Vyvanse).
However, there are a few conditions where CBD may work for which lisdexamfetamine is indicated or even work as an adjunct to it.
Researchers had initially believed that CBD could worsen the symptoms of ADHD, but studies have not found any evidence to support this. In fact, some research shows positive results using CBD for ADHD .
Depending on the severity of the problem, maybe CBD could be enough to help, but it’s always best to talk to your doctor before changing or adjusting medications.
CBD may also help patients who binge eat but, again, the research lacks anything conclusive .
One of the most significant differences between CBD and lisdexamfetamine is that the latter is more likely to result in dependence and withdrawal symptoms. Therefore, there is a chance that lisdexamfetamine can be misused and overdosed.
What Is Lisdexamfetamine (Vyvanse)?
Lisdexamfetamine (Vyvanse) is a derivative of the drug amphetamine and belongs to a class called central nervous system stimulant.
Vyvanse is the brand name of the drug lisdexamfetamine. It is a prodrug of the psychostimulant d-amphetamine.
It’s used mainly to treat attention deficit hyperactivity disorder (ADHD) and binge eating disorder. It’s a prescription medicine approved by the FDA that works by increasing the production and decreasing the metabolism of the neurotransmitters like dopamine, serotonin, and norepinephrine.
Lisdexamfetamine (Vyvanse) Specs:
|Trade Name||Vyvanse, Tyvense, Elvanse|
|Classification||Central nervous system stimulant|
|CYP Metabolism||CYP2D6 enzyme|
|Interaction With CBD||Antagonistic and Metabolic Inhibition|
|Risk of Interaction||Mild|
What Does Lisdexamfetamine (Vyvanse) Do?
Lisdexamfetamine (Vyvanse) can increase the attention span and decrease restlessness in children and adults with ADHD.
It’s also used for binge-eating disorders because of its appetite suppressant qualities.
Lisdexamfetamine for ADHD
ADHD is a disorder of the brain where the person tends to lack the ability to concentrate, has difficulty controlling impulsive behaviors, and is overly active.
The exact mechanism of ADHD is not completely understood. However, it is linked to genetics, exposure to environmental risks, and toxins during pregnancy, among other things.
People with ADHD may have a higher concentration of dopamine transporters in the brain. This means these transporters remove dopamine from the brain too fast, causing a decreased level of dopamine in the brain. There also tend to be low levels of serotonin and norepinephrine in the brain in those with ADHD.
Once consumed, lisdexamfetamine turns into dextroamphetamine and L-lysine. This drug has two optical isomers called trace-amine associated receptor 1 (TAAR1) and vesicular monoamine transporter 2 (VMAT2). It can enter monoamine neurons and release monoamine neurotransmitters like dopamine, serotonin, and norepinephrine from their storage places in presynaptic neurons.
These neurotransmitters help in alertness and increase and maintain concentration and motivation. It can also prevent the reuptake of these neurotransmitters from the synaptic cleft but does not bind to the sites of the reuptake of norepinephrine and dopamine.
Lisdexamfetamine for Binge Eating
The exact action of lisdexamfetamine (Vyvanse) on binge eating disorders is unknown. In binge eating disorders, food may trigger the brain to make more dopamine, the hormone that makes us feel pleasure.
It’s possible that lisdexamfetamine raises the dopamine levels in the brain and sustains it enough so that the person does not consume more food than necessary. However, this has not been proven yet.
Lisdexamfetamine may have less abuse potential compared to other amphetamines but can still cause dependence.
Side Effects of Lisdexamfetamine (Vyvanse)
Symptoms vary from minor to severe. It’s good to know what can happen so you can inform your doctor if you experience any.
- Loss of appetite
- Stomach upset
- Increased blood pressure
- Increased heart rate
- Blurred vision
- High possibility of substance abuse
If you’re using lisdexamfetamine and suspect you’re becoming dependant on it, speak to your doctor immediately. They can help you reduce the dose gradually to avoid withdrawal.
Lisdexamfetamine withdrawal symptoms include:
If you want to stop taking lisdexamfetamine and shift to CBD, you should talk to your doctor first. They may recommend slowly tapering this drug to avoid or to reduce the withdrawal symptoms.
Key Takeaways: Is It Safe to Take Lisdexamfetamine (Vyvanse) With CBD?
CBD can decrease the effects of lisdexamfetamine (Vyvanse) and even slow down its metabolism from the body, causing more unintended side effects.
This interaction is considered mild and low risk — but caution is still advised.
If you experience any adverse effects after taking CBD with Vyvanse, seek medical attention immediately.
ADHD med in morning and CBD oil in af. – CHADD’s ADHD Pare.
Hey everyone! I have a 9 year old son with ADHD, and he takes 20 mg of Vyvanse each morning. It is working very well for him, but he is metabolizing through it very quickly, and it is out of his system by 3:30. I was interested in possibly giving him some CBD oil in the afternoon to help with his symptoms in the afternoon/evening, but I’ve read here that some are saying that CBD oil should not be given with stimulant meds. Now, is that still the case if it isn’t given until after the meds have left the system? Is it okay to give it to him after the meds have worn off to help with the remainder of the day?
I appreciate your kind responses.
I have been given my son a low dose of CBD Oil in the morning and afternoon. Our doctor still has not prescribed us medication (that’s another discussion). We have seen a lot improvement with his anxiety but not much with the symptoms of ADHD. If you don’t mine me asking, approximately how many milligrams of CBD Oil do you give your son?
How do you know which is CBD oil to give?
HELLO! I JUST JOINED! I’M NOT SURE IF YOU’VE FINALLY PUT YOUR CHILD ON CBD OIL, BUT WE ARE STARTING THE ISOLATE SINCE THE BROAD FULL SPECTRUM CBD OIL HAS TRACE AMOUNTS OF THC, WHICH CAN AGGRAVATE ANXIETY MORE SINCE IT SPEEDS UP HEART RATE PLUS AT A YOUNG AGE IT IS BETTER TO AVOID THE THC BUT EVENTUALLY AS THEY GET OLDER IT SHOULDN’T BE MUCH OF AN ISSUE! THESE ARE THE DAYS WE ARE GUINEA PIGS SINCE WE DO NOT FULLY KNOW THE LONGTERM AFFECTS OF CBD OIL! THEY SEEM TO THING IT CAN SLOW DOWN RESPONSE BUT EVERYONE IS DIFFERENT PLUS THE BODY GOES THROUGH WITHDRAWALS WHICH IS SCARY! IT JUST DEPENDS ON YOUR SITUATION HOW SEVERE IT IS! MINE IS PRETTY SEVERE SO I HAVE EXHAUSTED OPTIONS! MY SON IS ON PROTANDIM WHICH IS A HOLISTIC OPTION! HE HAS DEFINITELY GOTTEN BETTER & COULD CONTINUE TO BUT HIS ADHD IS THROUGH THE ROOF & PROTANDIM AT THIS MOMENT IN TIME ISN’T AS AFFECTIVE! IT MAY BE DOWN THE ROAD BUT IN THE MEANTIME WE ARE STRUGGLING! I HOPE YOUR CHILD HAS IMPROVED! WISHING YOU THE BEST
Bring your concerns about the Vyvanse to your son’s doctor and talk about changes in dose or a different medication or supportive intervention. That is a better choice and a more effective one for your son than including CBD oil. It may be a relatively easy fix and one that the doctor can better assist you with.
There is not any evidence that CBD oil will treat ADHD symptoms, which are related to executive function. There is limited research into CBD oil for anxiety, which has been done in small groups with adults, only. There is no indication that it would be effective in treating ADHD symptoms in children.
Also, there hasn’t been research into possible interactions between CBD and other medications. So you run a chance of a medication interactions, especially since CBD oil is not regulated and you can’t be sure of what you actually have.
Furthermore, using CBD oil could make it difficult for you to get good treatment for your son in the future, as many professionals will decline to work with people or families that us cannabis products, including CBD oil.
You might find our Q&A “Will ADHD Symptoms Improve with Marijuana?” at bit.ly/nrcmarijuanaQA to be helpful.
The National Resource Center on ADHD
Our son is also on 20 mg vyvanse and some days it’s gone before 3. We’ve chosen to give a “booster” in the afternoon. It’s just 5 mg of Ritalin and it’s so much better. It took a couple of weeks to establish but makes such a huge difference in keeping evenings happier.
We are also doing a booster of our medication so he can get through homework, sports and the evening.
Vyvanse (like many stimulants) do have a short lifespan, which isn’t always bad for the long term health of our kiddos, but can be problematic for our kids “surviving” their last class of the day, completing any/all homework effectively/efficiently (without you and/or them wanting to rip your hair out), or participation in afterschool activities/sports. My son has ADHD (diagnosed at 5) and Autism Spectrum Disorder (diagnosed at 9) and has been on Vyvanse since he was 6 (was on Adderol at 5, but the weight loss and lack of sleep was too destructive). When my son began gymnastics, we quickly realized it wasn’t just a matter of being able to complete homework and focus during sports, it was also a SAFETY issue for him and his teammates since gymnastics can be dangerous if you’re not focused and impulsive. We opted to give him a fast-acting 5ml dose of Adderol (or was it Ritalin? It was a tiny oval blue tablet) afterschool (between ages 10-12) on the afternoons he had gymnastics practice (3+ days a week). It made a HUGE difference! I cannot impress upon you enough the benefits of discussing these concerns with his pediatrician/neurologist and if they don’t take you seriously, seek a second opinion elsewhere. As much as our family discourages the use of prescription medications, there are times and needs for them. I’ve seen so many kids who not only failed to succeed but also suffered social, emotional, and relationship detriments because it can take such a toll on them to “keep it together” to behave/act/appear like all the other neurotypical kids. I’d love one day for my son to not be on meds, as he’s getting older, we’re finding him taking more weekends off of meds (his choice) and we’re slowly seeing an increase in his ability to manage (he’s nearly 15 now) the symptoms of his ADHD/ASD, but it has taken a LOT of work at home, school, therapies, ADHD/ASD-specific summer camps (Talisman Programs) and kind/constructive conversations for him to become more self-aware so as to better negate, prevent, or diminish the challenges he faces from ADHD/ASD. At the end of the day, I believe our ADHD/ASD kids are quite brilliant, unfortunately they are on the outside looking in and sometimes feel trapped in their own mind/bodies. It takes so much effort to fit in with neurotypicals, it’s taken me years to personally wrap my own head around it. But I believe their unique qualities can help them succeed in ways that are not as effortless for neurotypicals. Companies like Microsoft are seeking individuals like our kids, because they can hyperfocus and see/do things that blow the rest of us out of the water Best of luck to you and your son. It does get easier, and some behaviors/challenges diminish, go away, or are replaced by different ones, but with your support, it does improve!