Cbd oil for nf1

How CBD can help for Neurofibromatosis

Let’s look at how CBD can help for Neurofibromatosis.

Neurofibromatosis, also known as NF, affects almost every organ system in the body. It´s a series of complex genetic disorders in which tumors grow in the brain, spinal cord and nerves throughout the body. Half of the people diagnosed with neurofibromatosis have inherited the condition. However, it is also possible that spontaneous cases occur through mutations in the genes.

Living with neurofibromatosis is a challenge. A study published in Genetics in Medicine discovered higher stress levels, more symptoms of depression and lower levels of self-esteem in a group of 248 people with this condition.

In addition, CBD has been responsible for slowing tumor growth rates and reducing their size.

Different cases

Each person reacts differently to the diagnosis of NF. When you have neurofibromatosis, you are likely to experience strong emotions. You may be afraid of what the future holds. Also, you can worry about possible changes in physical appearance and how others might react. You will also fight with feelings of isolation and perhaps fear. It is natural to feel numb and shocked when you have given a life-changing diagnosis.

Some people experience anger and denial, and you can too. You can isolate yourself from others and have no interest in the activities you once enjoyed. You may worry if you have children or not, since the condition is often inherited. Given all these factors, NF can cause an emotional burden for you and your partner or family.

CBD has proven to be a remedy for patients seeking relief from pain, anti-inflammatory effects and the treatment of Neurofibromatosis. It´s already known that it can stimulate the appetite of patients. However, researchers have learned that, in addition to having palliative benefits in cancer therapy, they have been associated with anticancer effects, which are responsible for preventing or delaying the development of cancer or tumor spread. In addition, CBD has been responsible for slowing tumor growth rates and reducing their size.

How CBD can help?

These are some of the symptoms of neurofibromatosis that CBD can help speed up:

– Tumors. It´s known that CBD has antitumor properties. This suggests that it may be useful to limit the growth and development of tumors related to NF. One study found that two children with NF1 saw a regression in their tumors over a period of three years. During this time, in addition to using CBD oil, no other treatment was used.

– Pain, mood and sleep. Many people use CBD to treat chronic pain and inflammation. It can also help you rest well at night. Depending on the dose, it is even useful to elevate the mood.

– Loss of appetite. We know CBD for returning users their appetite after having lost it due to the condition or treatment that accompanies it.

Treating Neurofibromatosis with Medical Marijuana

Medical marijuana treats symptoms of neurofibromatosis, such as mood disorders, pain, seizures, headaches, sleep problems, and fatigue. Cannabis can also be used to treat side effects of neurofibromatosis treatments. In addition, cannabis has anti-tumor effects that may be able to prevent or slow the growth of tumors.

What is Neurofibromatosis?

Neurofibromatosis refers to a group of rare, genetic disorders that cause tumors on nerves and growths in other areas of the body. Tumors may develop on the skin, brain, or spinal cord. Tumors in neurofibromatosis are usually benign or non-cancerous, but can sometimes become cancerous. Neurofibromatosis is caused by gene mutations in genes that suppress tumors. In some cases the gene mutation is inherited and in others is it a newly changed gene mutation.

Types of Neurofibromatosis

There are three main types of neurofibromatosis -NF1, NF2, and Schwannomatosis. Neurofibromatosis 1 (NF1) is the most common type and is usually apparent during childhood. It is characterized by bone deformities or curvature of the spine (scoliosis) and flat brown spots on the skin (cafe au lait spots). Children with NF1 may also be short in height and have a larger than normal head size. They may also experience tumors on the optic nerve, neurofibromes (benign tumors in or under the skin), and bumps on the iris of the eye.

Neurofibromatosis 2 (NF2) is a less common type that can be diagnosed from childhood through early adulthood. It usually causes benign tumors in the ears, called acoustic neuromas. These tumors can cause hearing deficits. Tumors may also affect nerves that control balance.

Schwannomatosis is a rare type of neurofibromatosis that is usually diagnosed in early adulthood. Benign tumors often develop on the cranial and peripheral nerves, as well as spinal nerves. Nerves that control hearing and balance are rarely affected.

Symptoms of Neurofibromatosis

Symptoms of neurofibromatosis vary based on the type and nerves affected by tumors. Common symptoms include pain, weakness of the legs, balance deficits, gradual hearing loss, tinnitus (ringing in the ears), headaches, vision problems, seizures, and loss of muscle. In rare cases, tumors may develop into cancerous tumors. Having neurofibromatosis increases the risk of some forms of cancer, including leukemia, breast cancer, and brain tumors. Some people with neurofibromatosis may have neurological deficits or learning disabilities.

Neurofibromatosis Treatment

There is no cure or standard treatment for neurofibromatosis. Symptoms are managed through pain medications, epilepsy medications, and anti-depressants. Surgery may be performed to remove tumors that damage organs or compress nerves. Radiation therapy can be used to shrink tumors. If a tumor becomes cancerous it is often treated with cancer therapies, such as chemotherapy or radiation. Tumors should be monitored closely, as well as blood pressure, bone deformities, vision, and hearing, to prevent complications.

Neurofibromatosis and Medical Marijuana

Neurofibromatosis may be an approved condition for medical marijuana treatment in some states. If it is not approved in your state, you may be eligible to receive medical marijuana through doctor approval or through a diagnosis of severe pain, headache disorder, seizures, or other symptoms of the condition or its treatments.

Medical marijuana relieves a majority of neurofibromatosis symptoms, has anti-tumor properties that slow the growth and development of tumors, and treats side effects of medications and treatments. Medical marijuana is an excellent treatment supplement and less harsh than pharmaceuticals. CBD dominant medical marijuana is non-intoxicating and can be used in pediatric conditions.

Case Study: CBD Improves Neurofibromatosis Symptoms

A 2019 case study of a 25 year old woman diagnosed with NF1 found that CBD dominant cannabis improved pain, depression, and anxiety over the three months of the study. The patient experienced severe pain and mood disorder due to NF1, which she was diagnosed with at puberty. She reported intense pain from the tumors themselves, as well as over 20 surgeries and laser treatments. She also struggled with crying episodes, stress, and migraine headaches. Anti-depressants were not tolerated due to their side effects and her migraine headaches were not relieved with pain medications. The patient’s symptoms interfered with her quality of life, ability to find employment, and resulted in social withdraw and overall stress.

After 3 months of using CBD oil in a 20:1 CBD to THC ratio twice per day in 8 milligram doses, her pain was reduced significantly. Pain scores dropped from an average of 6/10 to 1/10. The patient’s mood was stabilized and anxiety scores dropped from 9/10 to 3/10. Her migraine incidences dropped from 15 per month to only 5 per month. She also noted she was able to decrease dependence on anti-inflammatory medications for pain relief. This patient did not report negative side effects and the CBD dominant cannabis oil was well-tolerated.

Studies: Cannabis Reduces Tumor Size and Slows Tumor Growth

There is growing evidence that the cannabinoids in medical marijuana, such as THC and CBD, have anti-tumor properties that slow the growth and development of tumors.

Pre-clinical studies have found that cannabinoids induce cell death (apoptosis) in unhealthy, cancerous, and malignant cells, while keeping healthy cells alive.

In 2001 a multi-institutional and international research team showed a “considerable regression in the size of malignant tumors” using injected cannabinoids in animal studies.

In 2003 Italian researches found that CBD produces stress in brain cancer cells and promotes apoptosis, the process the induces death of cancer cells. CBD was able to promote apoptosis, or cell death, in unhealthy cells, but did not have this effect on normal healthy cells.

In Spain, researchers confirmed the cannabinoids including THC caused reduction in tumor size in animal studies in 2004.

One study of 2 children with neurofibromatosis found cannabis reduced tumors over a 3 year period as the only treatment.

Further research is needed at this time, however this pre-clinical and anecdotal evidence shows that cannabis has positive effects in reducing tumor size and slowing the growth of tumors. It is recommended to use cannabis in conjunction with other treatments, unless a knowledgeable doctor has agreed it is the best option.

Medical Marijuana Relieves Neurofibromatosis Symptoms

Medical marijuana can relieve the following symptoms of neurofibromatosis:

Cannabidiol (CBD) for Treatment of Neurofibromatosis-related Pain and Concomitant Mood Disorder: A Case Report

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Neurofibromatosis type 1 (NF1) is a common genetic disorder. Pain is a major symptom of this disease which can be secondary to the development of plexiform and subcutaneous neurofibromas, musculoskeletal symptoms (such as scoliosis and pseudoarthrosis), and headaches. Visible neurofibromas add significant psychosocial distress for NF1 patients. Along with the chronic pain, psychosocial distress contributes to associated mood disorders, such as depression and anxiety. Cannabis has been the focus of many studies for treating multiple conditions, including epilepsy, multiple sclerosis, Parkinsonism disease, and many chronic pain conditions. Cannabidiol (CBD) is the major non-psychotropic component of cannabis. CBD has shown anti-inflammatory and analgesic properties, as well as having mood stabilizer and anxiolytic effects. In this report, we present the use of cannabidiol (CBD) for the management of chronic pain and concomitant mood disorder in an NF1 patient.

Introduction

Neurofibromatosis type 1 (NF1) is one of the most common autosomal dominant genetic disorders, affecting approximately 1 in 2,600 to 3,000 people [1]. A mutation in the NF1 gene on chromosome 17 causes a loss of function or production of the neurofibromin protein, encoded by the gene. Clinically, NF1 is characterized by the presence of multiple café-au-lait spots, Lisch nodules of the iris, and neurofibromas. However, the widespread expression of the neurofibromin protein throughout the body and the variability in mutation expression involves multiple body systems that can vary greatly from one patient to another, between families, and even within a given family carrying the same mutation [2]. These patients have a high predisposition for developing benign and malignant tumors due to the loss of the tumor suppression property of the NF1 gene. More commonly, they can develop cutaneous and subcutaneous neurofibromas, gliomas of the optic pathway, malignant peripheral nerve sheath tumors, and gastrointestinal stromal tumors [3]. Chronic pain is commonly associated with this condition, mainly due to the development of these tumors, notably plexiform and subcutaneous neurofibromas, musculoskeletal symptoms (such as scoliosis and pseudoarthrosis), and headaches. These patients do not only suffer from physical distress but the accompanying body dysmorphia also affects their psychological well-being and overall quality of life [4]. In prior studies, the prevalence of pain among patients with NF1 ranged from 55% to 70%, with 35% of patients complaining of chronic pain [4-5]. More importantly, pain chronicity is related to mental health problems, including depression and anxiety [4]. These symptoms are worse when the disease presents on the face or other visible regions of the body. This leads to patients reporting increased psychological burdens related to issues of self-perception, drastically reducing their overall quality of life [5-6]. Although pain is clearly a frequent problem in NF1, with 41% of the patient’s reporting use of over-the-counter (OTC) or prescribed pain medications, it is still understudied and underreported in the medical literature [4, 7]

The goal of this case report is to demonstrate and present the use of cannabidiol (CBD), one of the major components of phytocannabinoids (plant cannabinoid), as a treatment option for managing NF1-related pain, anxiety, and depression, and increasing the overall quality of life in these patients.

Case presentation

A 25-year-old woman of African descent with NF1 presented to our clinic complaining of chronic pain, depression, and anxiety. She was diagnosed with NF1 at puberty but had reported symptoms since childhood. She was unaware of a family history of similar conditions. She has Lisch nodules on her iris bilaterally and 10 café-au-lait patches across her body. The patient also has numerous subcutaneous neurofibromas on her face (plainly visible and causing some facial disfigurement) and in several regions of her body. These caused her chronic, intermittent, sharp pain of varying intensity but averaging 6/10 on the 10-point pain scale. She has tried many OTC pain medications with limited benefits. She has had over 20 surgical resections and multiple laser treatments for the neurofibromas with limited success as they often recurred after treatment. She reports pain from both the treatment and the tumors themselves. The neurofibroma tumors have also caused her cosmetic issues. She reports being withdrawn, stressed, and anxious, especially in social situations when she feels that people are staring at her. She reports low energy and had lost interest in most activities. Furthermore, she reports that her condition has interfered with finding employment and leading a normal life. She states that her mood is low, and she has frequent crying episodes. Her general practitioner (GP) has prescribed multiple antidepressants that were not tolerated due to the side effects. Consistent with NF1 common symptoms, she reports having migraine headaches. She averages around 15 episodes per month varying in intensity between 5/10 and 10/10. She has reportedly used OTC pain medications for the migraines unsuccessfully.

CBD oil has no established dosing guidelines or maximum doses, except in psychosis (800 mg) and seizure disorders (2,500 mg or 25 – 50 mg/kg) [8]. Dosing is highly individualized and relies to a great extent on titration. The general approach to initiation is to “start low and go slow.” Many patients report benefits at low doses, starting with as little as 5 – 20 mg (0.25 ml – 1 ml) per day of oral oil preparations [8].

The risks and benefits of using cannabis for her condition were discussed in detail. She was advised to start a three month trial of sublingual CBD oil at 4 mg (0.2 ml) twice per day (BID) and titrate upwards to 10 mg (0.5 ml) BID with a maximum increase up to 20 mg (1 ml) BID if no response. She was advised to try and hold it in contact with the buccal membrane for at least 90 seconds [9]. The recommended formulation had low amounts of tetrahydrocannabinol (THC) at less than 1 mg per 1 ml of oil. The low levels of THC reportedly assist CBD in reaching the receptors, having a synergistic benefit [10].

At the three-month follow-up visit, the patient reported starting with 4 mg (0.2 ml) BID of cannabis oil with CBD to THC ratio concentrations of 20 mg/ml to 1 mg/ml (CBD: THC 20:1). This was gradually increased by the patient (self-titration) to 8 mg (0.4 ml) BID. During this period, the patient reported that her pain was significantly reduced (from an average of 6/10 down to 1/10). She reported being less emotional and feeling calmer. She said that her anxiety dropped from 9/10 down to 3 to 4/10 and that her mood had stabilized. Also, as an added benefit, she reported that her migraines had improved. She reported fewer episodes per month (five per month down from 15 per month before starting the CBD oil) and that she was able to decrease her dependence on OTC anti-inflammatory pills for pain relief. Overall, a significant improvement in her quality of life was evident by the change in her demeanor and a novel enthusiasm for seeking employment.

CBD is generally better tolerated by patients when compared to THC. Some patients may experience side effects, usually mild and infrequent, including fatigue, diarrhea, increased/decreased appetite, and somnolence [11]. These may be due to the low levels of THC in the formulation [12]. Our patient did not report any side effects during the treatment period.

Discussion

Cannabidiol (CBD) is the major non-psychotropic component of phytocannabinoids extracted from the Cannabis sativa plant. CBD interacts with the human endocannabinoid system mainly through two G-protein-coupled membrane receptors – cannabinoid receptor 1 (CB1) and cannabinoid receptor 2 (CB2). Predominantly, CB1 receptors are located in the central and peripheral nervous system, while CB2 receptors are found in immune cells. THC acts as an inverse agonist on these receptors, while CBD exhibits antagonist properties on them. Specifically, this antagonism on CB2 receptors inhibits immune cell migration and might explain the anti-inflammatory effects of CBD, as well as the attenuation of THC psychoactive side-effects [13]. Recent studies have also shown that CBD can interact with a wide range of other targets, such as sodium, potassium, and calcium channels, and serotonin and glycine receptors, independently from the CB1 and CB2 receptors [14].

CBD has been showing positive results in alleviating chronic pain. A large meta-analysis by Whiting et al. and other studies showed that cannabinoids are effective with neuropathic pain, fibromyalgia, cancer, and diabetic neuropathy, refractory pain due to multiple sclerosis and other neurological conditions, including rheumatoid arthritis, noncancer pain, central pain, musculoskeletal problems, and chemotherapy-induced pain [15-16]. Its efficacy with migraines and mood disorders has been consistently noted in the literature as well [17-19]. A recent preclinical study demonstrated effective neuropathic pain and comorbid anxiety and depression reduction through its interaction with the serotonin 5-HT1A receptor [20]. It is speculated that this might be the physiological model responsible for the noted improvement in the case study. Similarly, a study on the mechanism of pain in NF1 patients proposes that modulation of ion channels, specifically sodium channels, might be one of the pain pathways in these patients [7]. Giving the effect of CBD on these channels, it is postulated that the CBD might be modulating pain via this mechanism, as described above.

Current treatment options for pain in NF1 include OTC medications (such as ibuprofen and acetaminophen), prescribed pain medications (such as opioids, anticonvulsants, and anti-depressants), and surgical removal of neurofibromas. Other than emerging potential targeted therapies, specific treatments for NF1 are rather deficient due to the complex nature of the NF1 pathophysiology and the minimal understanding of its pain etiology [7].

Conclusions

Cannabidiol use with our patient has shown promising results in controlling the pain and concomitant mood disorder. Given our experience and the growing body of evidence for the efficacy of CBD in treating patients with multiple chronic pain conditions, it should be considered as a treatment option in the management of this patient group, especially when conventional pain medications have failed or were not well-tolerated. CBD also seems to have a positive effect on the psychosocial pain component of NF1. Nevertheless, more research targeted at understanding the etiology of the pain in NF1 and also more clinical trials using CBD for NF1 are still needed.

Notes

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