Ever thought about trying liposomal CBD? Learn everything you need to know about these products and where to buy the best CBD liposomes. The whole point of liposomal CBD is to increase absorption & make CBD oil stronger. But does it work? What are the best liposomal CBD oils? Liposomal CBD supplements manufactured by LIPOSOMA contain specific additives based on Vitamin E in the bilayer that further increase liposome stability.
What is Liposomal CBD Oil and How Does It Work?
Cannabidiol (CBD) is a compound found in the cannabis sativa plant (hemp), which was discovered in 1940 by British chemist, Robert S. Cahn. Research over the last few decades have showcased the benefits of CBD oil, which may help reduce pain, inflammation, anxiety, and depression, as well as promote healthy brain function and athletic performance.
Recent studies on the absorption of CBD molecules have also led to the creation of liposomal CBD oil, which is said to have improved efficacy due to its heightened bioavailability.
What is liposomal CBD?
Liposomal CBD is a form of hemp-derived CBD oil that has an increased absorption rate when compared to conventional application styles of CBD. This is due to a class of phospholipids called liposomes. Liposomes are spheres made of microscopic fat molecules, which are the primary building blocks of cell membranes. Owing to this structure, liposomes bond easily with cell membranes to facilitate intracellular delivery of nutrients.
Liposomal technology has been in use since its discovery in the mid 1960’s to aid in the absorption of prescribed medications, and now it’s making its way into the CBD industry. Additionally, liposomal CBD is one of the safest delivery methods since liposomes are non-immunogenetic (do not cause negative gene expression), non-toxic, and research continues to show no adverse side effects with their consumption.
How does liposomal CBD work?
In general, CBD oil works by stimulating the cannabinoid receptors, which are a part of the endocannabinoid system (ECS). The ECS is similar to the immune or cardiovascular system, but it helps maintain hormone balance and the regulation of many internal processes like pain sensation, mood, stress levels, and more. When introduced into the human body, CBD oil can have a positive impact in a variety of ways.
Liposomal CBD oil is absorbed similarly to a traditional CBD tincture, although with the support of liposomes, CBD can bypass potential damage from enzymes in the digestive system and make absorption quicker and more efficient. This is a significant characteristic, especially when taking CBD with a meal or other supplements because the gut can only absorb so much at one time. Liposomes, in a sense, put CBD molecules at the front of the “absorption line” so they’re uptake is prioritized.
As a consumer, this is definitely something to note. CBD oil can be an expensive supplement option, so making sure that you are getting what you pay for is an important part of buying and effective CBD product.
With liposomal CBD, you can ensure you get your money’s worth since there is a higher chance you are absorbing more CBD than you would if taking another form of CBD (i.e. capsules, tinctures, or edibles).
What is Liposomal CBD? Is it Worth The Money?
The whole point of liposomal CBD is to increase absorption & make CBD oil stronger. But does it work? What are the best liposomal CBD oils?
Liposomal cannabidiol is one of the most cutting-edge advancements when it comes to CBD products.
The CBD is placed in a microscopic “packaging,” called a liposome, that increases the bioavailability.
This means more of the CBD is available for your body to use.
Learn everything you need to know about liposomal CBD, including whether it’s right for you, in this article.
Table of Contents
What Is Liposomal CBD?
Liposomal cannabidiol, or liposomal CBD, refers to any CBD placed in liposomes before being packaged and sold.
The liposomes work to keep the CBD compound intact as it moves through your body, increasing bioavailability.
Bioavailability refers to the amount of a substance that’s able to go from the digestive tract to the blood, as well as the blood to the individual tissues.
Having a higher bioavailability makes a compound stronger and faster-acting.
What Are Liposomes?
Liposomes are microscopic “packaging,” that surrounds each individual molecule of a compound to protect it from normal bodily processes like digestion.
Liposomes are “sphere-shaped vesicles,” usually made of natural phospholipids — the molecules that make up our cell membranes — so they’re totally safe to ingest .
Liposomes are used for various medicines and vitamins to protect the compound from the point of ingestion all the way to absorption into the bloodstream. This doesn’t necessarily mean you’re getting 100% of the compound you’ve taken — your body almost always expels at least some of the compounds you ingest.
Note that not all medications can be liposomal. It works best with fat-soluble substances or minerals. CBD is fat-soluble and works great in liposomal form.
What Is Bioavailability?
The FDA defines bioavailability as an estimate of the fraction of the dose that is absorbed into the systemic circulation, a.k.a. the bloodstream.
Bioavailability is essentially the amount of a drug or other substance the body can actually “use.” It’s usually represented as a percentage.
The bioavailability of any substance depends on how it’s introduced to the body. Introducing a drug intravenously puts bioavailability at 100% because all of it enters the bloodstream.
When you take a substance orally or any other way, bioavailability can decrease due to the metabolic and digestive processes that are designed to break down the compounds we ingest.
Liposomes increase the bioavailability of CBD because they protect each CBD molecule from degrading during the digestion process. With the liposomal “packaging” around the compound, your body can take up more of the CBD inside rather than expelling some of it through urine or feces.
What Is The Bioavailability Of CBD?
It might shock you to learn that the bioavailability of most non-liposomal, oral CBD products is very low. CBD isn’t soluble in water, which can make it harder for your body to absorb the compound .
So, when you take a normal CBD gummy or tincture dose, a lot of the milligrams of CBD are filtered out during the metabolic process. This leaves the bioavailability of oral CBD at about 9% . For inhaled CBD products like vapes or flowers, bioavailability is greater — around 31% after smoking CBD .
Regardless of whether you choose to switch to liposomal CBD, it’s good to understand the approximate bioavailability of the products you like so you can have a better idea of how many milligrams of CBD your body is actually able to use.
However, keep in mind that bioavailability refers to the amount of the drug your body has the availability to take up — not necessarily the amount that actually moves into your bloodstream.
For instance, bioavailability can theoretically exceed 100%. That doesn’t mean your body would take up more than 100% of the drug that’s there, but rather that your body is available to move more than 100% of the drug into the bloodstream.
How Liposomal CBD Increases Bioavailability
Liposomal CBD increases the bioavailability of CBD by allowing the compound to stay in your system beyond the metabolic process, giving it time to absorb into your bloodstream, as we’ve covered.
The question is, how much of a difference do those liposomes really make?
A recent study compared liposomal and non-liposomal CBD, both taken orally . Forty percent of the patients who took the non-liposomal CBD had CBD in their blood one hour after ingestion. One hundred percent of the patients who took the liposomal CBD had CBD in their blood after the same period.
While there are limited studies on the increased bioavailability of liposomal CBD, the science is already there. Liposomes have been used since the 1960s for increased efficacy of tons of drugs and vitamins, all for the same reason that it’s being used for CBD now.
Compounds that are not fat or water-soluble simply need a little help getting into the bloodstream, and liposomes accomplish that.
Is Liposomal CBD Right For Me?
Despite the obvious benefits of liposomal CBD in terms of increased bioavailability, it might not be right for everyone. Because the technology is relatively cutting-edge within the world of cannabis, liposomal CBD products can be pricey and hard to find.
It’s also true that liposomal CBD isn’t really necessary if you prefer to take very low doses.
If a 50 mg dose of CBD is equivalent to around 25 mg of liposomal CBD, but the liposomal version is three times the price, it makes more sense to just use the standard CBD oil and take twice as much.
However, if you take very high doses of CBD, the price of liposomal CBD might start to feel worth it so you can get more out of the CBD you’re purchasing.
In terms of risk or difference in experience, liposomes will not impact your CBD in any way other than bioavailability. Liposomes are completely natural and non-toxic, and they’re designed to be absorbed into your blood. The only difference you might notice is higher efficacy; no additional side effects will take place .
Cannabidiol (CBD) is one of the several natural active ingredients of the Cannabis plant. It differs from tetrahydrocannabinol (THC) in that it lacks the well-known psychoactive effects .
Our liposomal supplements are superior in terms of effectiveness due to our proprietary formulation process and liposomal technology.
Our liposome experts have worked in clinical development of liposomal products, which require the highest quality standards.
Our liposomes are essentially non-toxic and biologically degradable.
Why Liposoma’s Liposomal CBD?
CBD is completely insoluble in water, poorly dissolves in alcohol and only dissolves well in oil. To be optimally absorbed in the intestines, CBD must be presented as individual molecules to the intestinal epithelial cells responsible for uptake of nutrients. In theory products with oily solutions could achieve this, but in practice the break up of an oil by the intestinal fluid and the process of dispersing it into tiny droplets ready for absorption is not straightforward and there are reports of poor bioavailability and high variability in uptake of CBD from oil products .
To make sure that CBD arrives in the gut in its active form, a solution is to incorporate it in liposomes, which are small, carefully designed phospholipid vesicles that form very stable dispersions in water . The phospholipids constitute a bilayer structure in which the CBD molecules can be safely kept dissolved, while at the same time they act as surfactants that help present them to the intestinal epithelial cells in the most optimal manner.
What is more, the liposomal supplements that are engineered by LIPOSOMA contain specific additives based on Vitamin E in the bilayer that further increase liposome stability and help protect its vulnerable contents against oxidation as well as attack of gastric fluids and enzymes.