Pure cbd oil for rls

Pure cbd oil for rls

If you’re kicking at night for unknown reasons, you might have RLS or Restless Leg Syndrome. People who’ve been on anti-depressants, for example, may notice an uptick in leg movement at night. That’s because RLS is a neurological-related condition which can cause problems for you as well as your sleeping partner.

In this post, we’ll look at RLS and new research that may show a connection between taking CBD and improved sleep, as well as potentially calming your legs at night. Although CBD for restless legs needs more research, there is an FDA-approved drug for epilepsy.

Keep reading to find out about CBD and how it might be an effective supplement to add to your nighttime regimen, especially if you suffer from RLS!

What Is RLS?

RLS is not only the sensation of “wanting to kick”; it’s also uncomfortable, though not usually painful. Typically taking place at night, before bed, RLS can also occur in the afternoon. Because RLS so often takes place in the late evening, many people report losing sleep. Most people with RLS report feeling some relief after “kicking” because RLS is a neurological disorder. An estimated 10 % of the U.S. population suffers from RLS.

Causes of RLS

Although the causes of RLS are not yet known, scientists speculate genetics may play a role in people who develop it before the age of 40. What researchers do know, however, is that RLS is related to activities in the brain, such as the basal ganglia. Low dopamine levels in the brain may also play a role in developing RLS.

Other factors that may play a role in developing RLS include the following:

  • An iron deficiency.
  • Long-term anti-depressant use.
  • Renal disease.
  • Alcohol use.
  • Excessive caffeine intake.
  • Fibromyalgia.
  • Pregnancy (last trimester).
  • Sleep deprivation.

RLS Signs and Symptoms

The most common sign you may have RLS is an irresistible urge to move. Although it may sound strange to someone who doesn’t have RLS, it’s no laughing matter. RLS can cause uncomfortable feelings such as:

  • Weird sensations in the legs, as well as the arms.
  • Itching, throbbing, or “crawling” feelings in the limbs.
  • Wanting to pace the floor at night.
  • Trouble staying asleep.
  • Trouble falling asleep.
  • Symptoms becoming more severe over time.

What Is CBD?

CBD, short for cannabidiol, is one of two primary compounds found in cannabis sativa, the other being THC (tetrahydrocannabinol). Both CBD and THC have been shown to exhibit medicinal properties for several diseases, including:

Unlike THC, CBD won’t get you high, and the World Health Organization (WHO) also states that CBD is safe and well tolerated. When ingested, CBD works by combining with receptors in your ECS (endocannabinoid system), a complex web of neurons controlling almost every aspect of your body, to produce desirable effects.

Is CBD Legal?

Yes, CBD is legal in the United States. In 2018, Congress passed the Farm Bill Act, making CBD legal – as long as it’s under 0.3% THC. Manufacturers, therefore, are required to properly label and sell their products online as long as their CBD meets the legal THC limit.

However, we’re still in the “wild west” in terms of state laws. Because science has only recently revealed the benefits of CBD (and the fact it won’t make you high), states may still lag behind legally.

How Is CBD made?

CBD is first extracted from hemp plants grown in either Europe or the U.S. There are many different ways to extract CBD. The purest and most popular technique is CO2 extraction. This involves using an expensive machine to remove solvents and residuals left from the extraction process.

Some companies favor an alcohol extraction method, which uses solvents like butane and ethyl to remove the CBD. Some report a cleaner taste with their CBD when it is extracted through the CO method.

How CBD May Help With RLS

Although research is limited, many people have reported remarkable results by using CBD for their RLS symptoms. RLS is typically treated with dopamine agonists (DA), which work well for most people. There is a subset of patients who don’t respond to medical treatment, which is why scientists are so interested in further studying CBD for RLS treatment.

Reduces Inflammation

One of the biggest markers of an underlying health condition is inflammation. Chronic, low-grade inflammation is often an underlying symptom for people suffering from RLS. People with RLS also suffer from low dopamine levels in the brain and other “inflammatory signals,” such as chronic fatigue.

When ingested, CBD combines with two receptors in the ECS – CB1, and CB2. When activated by CBD intake, scientists have discovered that patients’ inflammation signals went down. Research has shown that CBD indicates the ability to block inflammation signals and relieves oxidative stress (OS) responses in test subjects.

Eases Pain

One of the worst symptoms of RLS is that painful, “unknown” source that accompanies people at night. Patients report an uncomfortable throbbing or “crawling”. Although moving your legs or arms often relieves the tension, it’s only for a short time. With regular CBD therapy, RLS symptoms may improve due to its ability to block pain signals.

CBD binds to PPARy, adenosine, and vanilloid receptors to produce analgesic properties – like an all-natural ibuprofen. In one study, researchers showed CBD to be effective at helping symptoms associated with neuropathic pain, while another study demonstrated its ability to contract painful arthritis symptoms. Many RLS patients suffer from other neurological diseases like fibromyalgia, for which CBD has also shown favorable results.

Helps Muscle Spasms

Cramps and muscle pain can be relieved by applying a CBD-infused cream directly to the point of pain. As discussed, CBD is shown to block pain signals. One of the most common symptoms of RLS is periodic limb movement of sleep (PLMS) – a jerking motion lasting up to 30 seconds at a time.

By combining with your ECS system, CBD produces a calming effect. Your brain tells your muscles to relax and releases hormones that may also have an anticonvulsant effect. Many people take a CBD lotion in combination with CBD oil right before bed to achieve maximum benefit.

May Improve Sleep

One of the worst things about RLS is its interference with your sleep. You can go into a disease “loop” by not sleeping, where you’re now fighting off even more inflammation because of lack of rest. Studies have shown CBD may potentially help patients suffering from insomnia. This is good news for RLS patients.

If you’re still concerned about proper rest, consider adding other cannabinoids such as CBG or CBN to your nightly regimen. CBG and CBN are two potent compounds that, combined with CBD, may provide an excellent way to fall asleep faster and stay rested.

How To Find The Best CBD To Treat RLS

When choosing your CBD, there are a few things you’ll want to consider. First of all, where is your CBD coming from? Look for CBD made from American-grown hemp that is 100% organic. This means that not only is it free of pesticides, you’re also helping U.S. farmers! Secondly, you’ll want to make sure your CBD has been tested and approved by a third party.

Why Is CBD Testing Important?

Most importantly, you want to know exactly where your CBD comes from, and whether it is pure. The other important reason to validate your CBD is legality. By law, any CBD over 0.3% THC is considered illegal. Plus, you may not want to ingest any THC over the legal amount, as it may cause unwanted psychotropic effects.

Full-Spectrum CBD vs. THC-Free CBD

One of the most common questions is, “what’s the difference between Full-Spectrum and CBD Isolate?”. Apart from not containing THC, there are some important considerations you may want to know before purchasing your CBD.

Full-spectrum CBD

Full-spectrum CBD can contain over 100 active compounds, responsible for its medicinal profile. Researchers have shown increased metabolic absorption when these compounds, such as CBD and THC, are ingested together. From a medical perspective, this “entourage effect” is thought to provide optimal therapy.

THC-Free and CBD Isolate

For those on the go or who are concerned about drug testing, CBD isolate may be a better option.

How Much CBD Should I Take For RLS?

After starting CBD, be patient with the results. It may take up to two weeks to start seeing any improvement in your RLS symptoms. CBD can be taken daily – preferably at night before bed. Most oil tinctures come with droppers conveniently marked for easy measurement and dosing

If you’re new to CBD, start with ¼ ml for one week at night and listen to your body. After that, bump up your dose to ½ ml for another week. You should start to see gentle improvement by this time, and your body will have acclimated to the CBD. You can then go up to full strength every night – 1 ml per drop.

You can also try working a CBD lotion to your nighttime regimen. Start by working in a dime-sized drop into your legs and work your way up to a quarter-sized drop. Of course, everybody has a different metabolism, and some people may have a severe case of RLS – which requires more potent CBD.

CBD for Restless Legs Syndrome: Effects & Dosage

Untreated restless legs syndrome (RLS) has consequences that affect your overall quality of life. It prevents you from getting restful sleep, which impacts your physical health. It also puts you at risk of developing mental health issues such as depression and anxiety.

Medications help control RLS symptoms, but prolonged use of these drugs sometimes has ugly side effects.

CBD, as research studies suggest, has properties that may help control your RLS symptoms and improve your quality of life. It’s also non-psychoactive, non-toxic, and safe.

Read more to know what RLS is, how CBD helps with this neurological disorder, and how to use CBD for restless legs syndrome.

What is Restless Legs Syndrome?

Restless legs syndrome is a type of neurological disorder that causes a painful throbbing, pulling, itching, or electric sensation in the legs. An uncontrollable need to move the legs also accompanies the sensation.

These unpleasant sensations typically occur late in the afternoon or the evening hours but progressively worsen at night when you’re resting or sleeping. The symptoms also often wake you up and prevent you from going back to sleep. Inactivity, prolonged sitting, and stress typically make the symptoms worse, and moving the legs or walking relieves them.

RLS has no known cause, but a 2020 study published in the International Journal of Environmental Research and Public Health suggests that genetics, kidney disease, and an imbalance in the neurotransmitter levels in the brain may be the causative factors .

Health problems like peripheral nerve damage, kidney failure, iron deficiency, and spinal cord problems also increase RLS risks.

How is Restless Legs Syndrome Treated?

If left untreated, RLS will start affecting the quality of your life.

Because you’re not getting enough sleep, you’ll feel exhausted all the time, with your daytime fatigue affecting your activities of daily living. Mood swings, easy irritability, inability to concentrate, poor memory, short attention span, and sleep deprivation may also occur. Sleep deprivation and RLS symptoms will also impact your mental health and may cause anxiety and depression.

The treatment for RLS consists of finding the underlying cause and treating the problem. Once the root cause is treated, there’s usually an improvement in the RLS symptoms.

If no underlying cause was found, then lifestyle modification may be suggested. These include:

  • Diet change
  • Regular exercise program
  • Healthier sleep habits
  • Warm baths
  • Avoidance of caffeinated beverages
  • Smoking or alcohol cessation

Prescription medications may also be given such as:

  • Muscle relaxants for muscle cramps and spasms
  • Sleep aids for sleep problems
  • Painkillers like opioids for severe pain
  • Anticonvulsant drugs like gabapentin
  • Dopamine agonists like rotigotine and ropinirole
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Short-term effects of these drugs may cause nausea, dizziness, and fatigue. However, prolonged use may also result in drug tolerance, in which case you’ll need a higher dose of the same medication or a different medication altogether. Long-term use may also cause worsening of your RLS symptoms.

CBD, on the other hand, is a safe, non-toxic, and non-psychoactive cannabinoid that may be used for RLS. Before we discuss CBD for restless legs syndrome, let’s first go over the role of the endocannabinoid system.

The Endocannabinoid System and Restless Legs Syndrome

The endocannabinoid system (ECS) is involved in many physiological functions — from regulating appetite and stress to controlling an abnormal inflammatory response. It consists of three components: the endocannabinoids, the cannabinoid receptors (CB1R and CB2R), and the enzymes that degrade the endocannabinoids.

You’ll find cannabinoid receptors all over the body, including the peripheral tissues. However, the brain and the spinal cord have the most abundant numbers of CB1R. This is why its activation results in the modulation of many physiological functions such as appetite, hunger, fear, memory, stress, anxiety, pain, pleasure, sleep, as well as sensory and motor responses, etc.

The CB2R, on the other hand, is mostly found in the immune system, and its activation results in decreased inflammation.

The main role of the ECS is to make sure there’s a balance among the different chemicals inside the body. Unfortunately, noxious stimuli like pain, infection, or diseases easily disrupt this balance and cause symptoms. If left untreated, this imbalance can contribute to ECS dysfunction.

In RLS, for example, low levels of dopamine in the region of the brain controlling motor movements cause painful muscle spasms and cramps. Iron deficiency also contributes to fatigue, dizziness, and joint pains, which worsen RLS symptoms .

Studies suggest that inflammation caused by chronic health problems also plays a role in the worsening of RLS symptoms. It contributes to abnormal dopamine and iron levels in the brain .

We lack studies that focus on the ECS and RLS, but ECS dysregulation has been implicated in diseases like multiple sclerosis, Huntington’s disease, and Parkinson’s disease . Similar to RLS, these neurological diseases also cause motor problems. Parkinson’s disease, in particular, shares similar features with RLS since they both have abnormal dopamine levels .

According to an issue published in the Brazilian Journal of Psychiatry, patients with Parkinson’s disease respond well to CBD . This effect may be one of the reasons why CBD for restless legs helps.

What are the Effects of CBD for Restless Legs Syndrome?

CBD is a non-psychoactive cannabinoid that doesn’t dock very well on the CB1R. However, it binds to several receptors like the serotonin, vanilloid, adenosine, and PPARy receptors to produce its therapeutic effects.

CBD directly stimulates the CB2R though, producing a strong anti-inflammatory response.

Below are the effects CBD may have on RLS symptoms.

CBD for Pain

The classic symptom of RLS is pain in the legs that get worse at night. It’s often described as throbbing, pulling, crawling pain inside the legs, and some also describe it as an itching and electric pain. The pain becomes severe when resting or sleeping, and an uncontrollable urge to move the legs often temporarily relieves the unpleasant sensation.

CBD produces strong analgesic effects when it binds to the vanilloid, adenosine, and PPARy receptors . These receptors play active roles in controlling pain sensation.

When CBD binds to these receptors, the cells stop secreting pain-generating compounds. They start releasing compounds that counteract the effects of the pain-generating ones. This CBD effect also stimulates the cells to reabsorb the pain-generating chemicals, reducing their levels in the system.

CBD for Inflammation

Low-grade inflammation caused by chronic health problems plays a role in RLS and may contribute to the decreased dopamine and iron levels in the brain, fatigue, and chronic widespread pain .

CBD exerts its anti-inflammatory effects through the CB2R, serotonin, vanilloid, PPARy, adenosine, and GPR55 receptors. Activation of these receptors results in apoptosis or cell death of the immune cells. This effectively stops the immune cells from sending signals for more immune cells to the site .

This CBD effect only affects the abnormal immune cells while protecting the healthy cells.

CBD for Muscle Spasms and Cramps

The National Institute of Neurological Disorders and Stroke notes that more than 80% of the individuals suffering from RLS also complain of periodic limb movement of sleep (PLMS). These muscle jerks and spasms typically occur during sleep, with an interval of about 15 to 40 seconds between each involuntary movement .

CBD produces muscle relaxant effects and anticonvulsants through the non-cannabinoid receptors. Their activation prompts the brain cells to slow down their release of excitatory neurotransmitters while increasing their release of inhibitory ones. CBD also allows the endocannabinoids to stay longer in the system by attaching to the enzymes that break them down .

CBD for Stress, Anxiety, and Depression

If you’re suffering from RLS, you’re at a higher risk of developing chronic stress as well as depression and anxiety. RLS also makes you more vulnerable to panic disorders .

CBD reduces stress and anxiety, and it also improves symptoms of depression by stabilizing the abnormal neurotransmitter levels in the brain. Again, these CBD effects are through its activation of non-cannabinoid receptors such as the vanilloid and serotonin receptors .

CBD for Sleep

You never get a full, restful sleep when your RLS attacks. The painful sensation keeps you up at night, and the muscle twitches sometimes pull you out of sleep. If left untreated, RLS results in sleep deprivation, which impacts your overall mental and physical wellbeing.

CBD not only relieves several symptoms associated with RLS but also improves sleep. A study published in The Permanente Journal revealed that CBD improved the duration and quality of sleep in patients with anxiety problems.

CBD for Restless Legs Syndrome

We lack specific studies that focus on CBD for RLS, but one notable study published in Sleep Medicine showed that smoking marijuana and sublingual CBD improved the sleep quality of six patients with RLS .

The study also noted that cannabis use was effective in controlling RLS symptoms. It’s also well-tolerated by the patients.

How to Find the Best CBD Dose for Restless Legs Syndrome?

Unlike other popular supplements in the market, CBD doesn’t have a recommended daily intake. Yes, you’ll see label instructions tell you to take one dropper daily, but the CBD dose it contains may not be the best dose for you. Depending on the total milligrams of CBD in the bottle, one dropper can either be too low or too high.

The best way to find your CBD dose is to follow this simple rule:

  • For mild symptoms or low-strength CBD, take 1 mg of CBD per 10 pounds body weight
  • For moderate symptoms or medium-strength CBD, take 3 mg of CBD per 10 pounds body weight
  • For severe symptoms or high-strength CBD, take 6 mg of CBD per 10 pounds body weight

For example, if you weigh 120 pounds and have mild RLS symptoms, then you need at least 12 mg of CBD (36 mg of CBD for moderate symptoms and 72 mg of CBD for severe symptoms).

Let’s say you bought a 30 mL bottle containing a total of 750 mg of CBD, then divide 750 by 30, and you get 25 mg of CBD per one full dropper. Each dropper contains at least 20 drops, so divide 25 by 20, and you get 1.25 mg of CBD per one drop.

Since you need 12 mg of CBD for your mild RLS symptoms, divide 12 by 1.25 and you get 9.6. This means that you need at least 10 drops for symptom control.

You can also buy extra-strength CBD oil for moderate to severe symptoms. It may be a bit pricier, but it will last you a long time.

How to Choose the CBD Product?

Looking for CBD products shouldn’t be difficult. CBD’s popularity has made it readily available in the market. However, this doesn’t mean though that you have to buy the first product you see.

Instead, you should be extra careful when buying CBD to avoid mistakes, especially since there’s the risk of buying illegal and/or substandard CBD products.

When buying CBD, always consider these factors.

CBD Source and Extraction Process

Make sure it’s an organic CBD that is sourced from organically grown plants. This reduces your risk of buying contaminated CBD products since no artificial fertilizers and pesticides were used in growing the plants.

There are many ways to extract CBD, including the use of solvents like ethanol, alcohol, butane, oil, and carbon dioxide. Of these methods, the supercritical CO2 extraction process is, by far, the safest and cleanest method that produces pure, residue-free CBD.

CBD Legal Status

The 2018 Farm Bill legalized industrial hemp . This means that we can now use all the parts of the plant legally, including its leaves, stems, flowers, cannabinoids, extracts, derivatives, isomers, acids, etc., as long as its THC level doesn’t go over 0.3%. Cannabis plants containing more than 0.3% THC are considered marijuana and are illegal under federal laws.

People, regardless of age, have access to hemp-derived CBD products. You don’t need to get a letter of recommendation or a prescription from your doctor. You can simply buy CBD from dispensaries, health stores, and online CBD shops. There’s also no restriction to the amount of hemp-derived CBD products you can possess.

Marijuana-derived CBD products, on the other hand, are only available to people residing in states that legalized marijuana. Some states require patients to register into their medical marijuana program to get a card, while other states don’t. You only have to present a valid ID as proof that you’re of legal age to buy marijuana-derived CBD with higher THC content.

Before buying CBD products, we recommend checking your state’s cannabis laws.

Certificate of Analysis

One of the differentiating factors between a good CBD and a bad CBD product is its COA.

Legitimate CBD producers send samples of their products to certified facilities for laboratory testing. The tests look for contaminants such as heavy metals, toxic residues, residual solvents, harmful microbes, etc. They also check the potency of the products by getting the cannabinoid profile and their concentration.

The COA is proof that the product underwent third party testing. You’ll see this on the product label and the producer’s website.

Don’t buy CBD products that don’t have COAs. You’re not guaranteed their safety, quality, and potency.

Types of CBD

When choosing CBD products, you’ll encounter the different types of CBD products:

  • Pure CBD which has only CBD and no other extra ingredients
  • Broad-spectrum CBD which also has other cannabinoids and terpenes
  • Full-spectrum CBD which also has THC, in addition to the extra cannabinoids and terpenes

They all help, but with full-spectrum CBD oil, you also benefit from the entourage effect. This is a cannabis phenomenon that states that all the compounds found in the plant (including THC) work together and boost each other’s therapeutic effects.

Forms of CBD

You’ll also encounter different forms of CBD such as sublingual, edible, inhalable, and topical CBD products.

Sublingual and inhalable CBD products give you fast relief since the cannabinoid bypasses the digestive organs and the liver. You’ll feel the effects in under 30mins. However, the effects don’t last as long as edibles.

Edible CBD takes some time before you feel the effects (about 30 minutes to 1.5 hours) since it goes through the digestive system and liver first before joining the blood circulation. However, the effects last longer since the cannabinoid circulates in the body for a longer period.

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Topical CBD creams stimulate the cannabinoid receptors found on the skin and helps provide immediate relief to muscles and joints.

Product Reviews

Once you’ve chosen a CBD product (with consideration to the factors above), the last step is to read reviews. Customer feedback and their experience already tell a lot about the CBD product.

Of course, stay away from CBD products that received more negative than positive reviews.

Is CBD Safe?

CBD is safe and nontoxic . There may be some side effects like eye and mouth dryness or lightheadedness, but these are usually well-tolerated and typically go away in time.

Final Thoughts — Can CBD for Restless Legs Syndrome Help?

Can CBD for restless legs syndrome help control symptoms?

There’s no study yet that purely focuses on CBD for RLS, but other CBD studies show that this non-psychoactive cannabinoid has many properties that relieve RLS symptoms. It helps with the unpleasant sensations in the legs, and it also relaxes the muscles. CBD may also help with associated RLS symptoms like sleep loss, increased anxiety, and depression. Moreover, CBD helps control low-grade inflammation, which contributes to the worsening of RLS symptoms.

Are you using CBD for restless legs syndrome? Has it helped with your symptoms? Comment your story below!

References Used in This Article:

  1. Seeman M. V. (2020). Why Are Women Prone to Restless Legs Syndrome?. International journal of environmental research and public health, 17(1), 368. https://doi.org/10.3390/ijerph17010368
  2. Memon, M. D., Faiz, S., Zaveri, M. P., Perry, J. C., Schuetz, T. M., & Cancarevic, I. (2020). Unraveling the Mysteries of Restless Leg Syndrome. Cureus, 12(10), e10951. https://doi.org/10.7759/cureus.10951 [1]
  3. Weinstock, L. B., Walters, A. S., & Paueksakon, P. (2012). Restless legs syndrome–theoretical roles of inflammatory and immune mechanisms. Sleep medicine reviews, 16(4), 341–354. https://doi.org/10.1016/j.smrv.2011.09.003 [2]
  4. Centonze, D., Battistini, L., & Maccarrone, M. (2008). The endocannabinoid system in peripheral lymphocytes as a mirror of neuroinflammatory diseases. Current pharmaceutical design, 14(23), . https://doi.org/10.2174/138161 2 08785740018
  5. Tan E. K. (2006). Restless legs syndrome and Parkinson’s disease: is there an etiologic link?. Journal of neurology, 253 Suppl 7, VII33–VII37. https://doi.org/10.1007/s00415-006-7008-1
  6. Rieder C. R. (2020). Cannabidiol in Parkinson’s disease. Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999), 42(2), 126–127. https://doi.org/10.1590/1516-4446-2019-0810
  7. Russo E. B. (2008). Cannabinoids in the management of difficult to treat pain. Therapeutics and clinical risk management, 4(1), 245–259. https://doi.org/10.2147/tcrm.s1928
  8. Stehlik, R., Ulfberg, J. (Neuro)Inflammatory Component May Be a Common Factor in Chronic Widespread Pain and Restless Legs Syndrome. Curr Sleep Medicine Rep 6, 121–128 (2020). https://doi.org/10.1007/s40675-020-00180-0 [3]
  9. Atalay, S., Jarocka-Karpowicz, I., & Skrzydlewska, E. (2019). Antioxidative and Anti-Inflammatory Properties of Cannabidiol. Antioxidants (Basel, Switzerland), 9(1), 21. https://doi.org/10.3390/antiox9010021 [4]
  10. National Institute of Neurological Disorders and Stroke. (2020, March 17). Restless Legs Syndrome Fact Sheet. Retrieved September 3. 2021, from https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Fact-Sheets/Restless-Legs-Syndrome-Fact-Sheet
  11. Peres, F. F., Lima, A. C., Hallak, J., Crippa, J. A., Silva, R. H., & Abílio, V. C. (2018). Cannabidiol as a Promising Strategy to Treat and Prevent Movement Disorders?. Frontiers in pharmacology, 9, 482. https://doi.org/10.3389/fphar.2018.00482 [5]
  12. Winkelmann, J., Prager, M., Lieb, R., Pfister, H., Spiegel, B., Wittchen, H. U., Holsboer, F., Trenkwalder, C., & Ströhle, A. (2005). “Anxietas tibiarum”. Depression and anxiety disorders in patients with restless legs syndrome. Journal of neurology, 252(1), 67–71. https://doi.org/10.1007/s00415-005-0604-7
  13. de Mello Schier, A. R., de Oliveira Ribeiro, N. P., Coutinho, D. S., Machado, S., Arias-Carrión, O., Crippa, J. A., Zuardi, A. W., Nardi, A. E., & Silva, A. C. (2014). Antidepressant-like and anxiolytic-like effects of cannabidiol: a chemical compound of Cannabis sativa. CNS & neurological disorders drug targets, 13(6), 953–960. https://doi.org/10.2174/1871527313666140612114838
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Nina Julia

Nina created CFAH.org following the birth of her second child. She was a science and math teacher for 6 years prior to becoming a parent — teaching in schools in White Plains, New York and later in Paterson, New Jersey.

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21 Best CBD Creams for Restless Leg

This article contains affiliate links to products. We may receive a commission for purchases made through these links.

Restless leg syndrome is a neurological disorder that causes an uncontrollable urge to move one’s legs. The condition, which can be accompanied by other symptoms like sleep disturbance and pain in the legs, is estimated to affect between 4% and 14% of adults. Today we’re going to share a new option to help relieve the symptoms of restless leg; CBD creams!

Aspen Green Pain Relief Balm

Cornbread Hemp CBD Lotion

FOCL Relief Cream

Leaf Remedys Cooling Cream

Level Select 2 Cream

Lord Jones CBD Body Oil

Medterra Pain Relief Cream

Naternal CBD Salve

NuLeaf Naturals CBD Salve

Pure Hemp Isolate

R+R Medicinals Cream

Vertly CBD Lotion

CBDfx Muscle and Joint Cream

What is restless leg syndrome?

Restless leg syndrome is a disorder in which one experiences an overwhelming urge to move the legs. People with restless leg syndrome are unable to sit or sleep for more than a few minutes and will experience uncomfortable sensations like itching, tingling, numbness, pins, and needles, or even burning pain.

These intense feelings cause the sufferer to have an uncontrollable urge to move the legs. Restless leg syndrome can also cause other symptoms, such as not being able to sleep, excessive yawning while trying to fall asleep, and feelings of exhaustion during the day.

What causes restless leg syndrome?

The exact cause of restless leg syndrome is unknown; however, certain factors can play a role in its development, such as caffeine intake, deficiency of certain minerals like iron and magnesium, lack of physical activity or exercise, pregnancy, stress or anxiety, dehydration, depression, fatigue, alcohol consumption, smoking cigarettes, and some medications.

What are CBD creams for restless leg?

CBD creams, also known as pain relief lotions or topicals, are a form of cannabinoid that is applied directly to the skin. The cream absorbs through the skin and interacts with cannabinoid receptors throughout different layers of tissue.

CBD creams have been shown to offer an effective treatment option for those suffering from chronic pain and inflammation without causing a psychoactive high.

How does CBD help restless leg syndrome?

Cannabidiol is one of the compounds found in cannabis that is responsible for its effects on the body. Studies have shown that it can effectively help with pain, inflammation, and anxiety.

There are several ways CBD interacts with the brain to relieve painful symptoms associated with restless leg syndrome:

● CBD reduces pain by interacting with both opioid receptors, which are responsible for pain relief and serotonin receptors in the brain.

● CBD activates melatonin receptors to help regulate sleep patterns. Restless leg syndrome is often associated with sleeping disorders like insomnia or poor sleep quality.

● CBD has been shown to improve sleep by regulating the body’s circadian rhythm.

● CBD reduces inflammation by inhibiting the release of cytokines, an immune system response that is responsible for pain and swelling.

● CBD enhances the body’s natural analgesic effects by suppressing the secretion of neurotransmitters that are responsible for feelings of pain.

How do I use CBD creams for restless leg?

Just like with any topical pain reliever, it is recommended to apply a small amount of the cream directly on the skin. A suggested starting dosage for restless leg syndrome is four times a day, and higher doses have been used successfully by others suffering from chronic pain conditions.

The inflammation associated with restless leg syndrome causes severe pain in some cases; therefore, it is important that you increase your dosage if the pain becomes unbearable. Test the CBD creams for restless leg until you find the best dosage and brand for your current symptoms.

What are some other ways to treat restless leg?

Since CBD creams can be used to provide pain relief, they are often used as a treatment method for restless leg syndrome. However, there are several other options that may help relieve your symptoms:

Hot showers

Taking a hot shower is a great way to provide temporary relief from the pain associated with restless leg syndrome. Try taking a hot shower to relax your muscles and ease the pain before bedtime.

Reducing stress and anxiety

Some medical studies have shown that people suffering from restless leg syndrome tend to feel more anxious and stressed than those who do not suffer from this condition. If you are feeling overwhelmed with daily life, take some time for yourself throughout the day to rejuvenate, meditate, and reflect on what you’re thankful for.


For an over-the-counter pain reliever, try an anti-inflammatory like ibuprofen first. You can also use CBD creams in combination with ibuprofen to reduce inflammation and provide quick relief.

CBD oil

If CBD creams are not effective at reducing your symptoms, try taking a full spectrum CBD oil instead. Since the oil is ingested orally, you will be able to get all of the benefits of cannabis without dealing with any sort of side effects that may be associated with the topical ointments.

What criteria should one consider before choosing CBD creams for restless leg?

There are several factors to take into consideration when deciding which CBD cream is right for you:

Quality of ingredients

You should always be concerned about the quality and purity of the CBD used in the creams. Avoid products that do not list their ingredients and try to find one with a full-spectrum cannabinoid extract.

Concentration of cannabinoids

In order to determine the potency of a CBD cream, you should look at its cannabinoid concentration. A higher mg/ml value indicates that there is more CBD in the product.


Some creams are more expensive than others due to their ingredients and production process. By looking at a CBD cream’s price, you will be able to determine how much you are paying for its ingredients.

Type of base

There are two types of bases that CBD creams can be made out of: water-based and oil-based. Water-based CBD cream is easier to apply but it might not provide the longer-lasting effects associated with oils.

Frequency of application

Because CBD creams for restless leg are a topical treatment, you can choose to apply it as often as necessary. However, there is no scientific research to indicate precisely how many times a day you should use the cream.

Who manufactures CBD creams for restless leg?

There are several popular brands of CBD skin care products available on the market today:

1. Penguin CBD

Image courtesy Penguin CBD

Penguin is a premier brand of CBD creams for restless leg formulated with essential oils and natural ingredients to relieve pain from sciatica, plantar fasciitis, neuropathy, migraines, cancer/chemo treatment, and arthritis. Penguin CBD cream is formulated with full-spectrum CBD oil from hemp plants, which has been extracted from its stalks and stems.

2. Everest

Image courtesy Everest

Everest is a popular brand of CBD creams that provides effective relief from symptoms associated with chronic pain, arthritis, and cancer/chemo treatment. Their products have added health benefits such as increased skin hydration and improved sleep quality.

3. Verma Farms

Image courtesy Verma Farms

Verma Farms is a CBD company that uses a combination of CBD and essential oils to treat various skin conditions. Their line of products includes a cream for menstrual pain relief, muscle soreness, arthritis, neuropathy, moles/skin tags removal, scars reduction/removal, scar treatment, wart treatment, stretch marks reduction/removal, and dark circles reduction/removal.

4. Aspen Green Pain Relief Balm

Image courtesy Aspen Green

Aspen Green Pain Relief Balm is a therapeutic balm that uses organic hemp and essential cannabinoids to deliver relief. The organic ingredients and lack of synthetic ingredients make it a safe and toxin-free product. It’s also gluten-free and non-GMO.

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5. Batch CBD

Image courtesy Batch CBD

Batch CBD manufactures products that are 100% natural and organic. The company uses full-spectrum cannabinoids to deliver relief from pain, inflammation, mood disorders, anxiety, depression, stress, and restless leg syndrome.

6. cbdMD Cream

Image courtesy cbdMD

cbdMD has a wide range of CBD-infused creams and oils that target aches and pain in the body. They also offer hemp oil capsules, which you can consume orally to get the same relief as topical ointments. The last product cbdMD offers is an oral spray that gets absorbed directly into the bloodstream, which makes it a convenient way to use CBD for pain relief.

7. CBDmedic Lotion

Image courtesy CBDmedic

CBDmedic lotion is a CBD cream that uses all-natural ingredients to relieve pain. It’s easy to use and it doesn’t leave any greasy residue behind after you apply the cream on your skin.

8. Cornbread Hemp CBD Lotion

Image courtesy Cornbread Hemp

Cornbread uses full-spectrum CBD oil to deliver relief from multiple health conditions, including arthritis, chronic pain, and neuropathy. The CBD cream is made with organic hemp and essential oils and it comes in 3 different concentrations: 200 mg/3.5 oz., 600 mg/8 oz., and 1,500 mg/16 oz.

9. FOCL Relief Cream

Image courtesy FOCL

FOCL uses a blend of healthy hemp oil, coconut oil, and essential oils to provide long-lasting relief from pain. The cream is formulated with full-spectrum CBD from hemp plants and it has more than 10 cannabinoids in its formula.

10. Healthworx CBD

Image courtesy Healthworx

Healthworx CBD oil is known for its high-quality ingredients and their full-spectrum CBD extract. This CBD product is made with hemp oil, which you can use to manage pain associated with arthritis, skin irritations, scars/wounds, sunburn, psoriasis, dermatitis, and more.

11. Leaf Remedys Cooling Cream

Image courtesy Leaf Remedys

The Leaf Remedys Cooling Cream uses CBD-infused oil to relieve pain and inflammation. The ingredients come from natural sources, making it safe to use without worrying about the potential negative effects of synthetic ingredients.

12. Level Select 2 Cream

Image courtesy Level Select 2

Level Select 2 Cream offers natural relief for multiple aches and pains, including muscle pain, arthritis, chronic back pain, neck/shoulder/back pain, sciatica nerve pain, ligament sprains or tears, cramps and spasms of muscles or joints – on legs or elsewhere on the body. The topical cream is free from THC and uses a blend of CBD and essential oils to deliver pain relief.

13. Lord Jones CBD Body Oil

Image courtesy Lord Jones

Lord Jones CBD Body Oil is a topical hemp oil cream that absorbs quickly into the skin for fast pain relief. The formula combines full-spectrum CBD, nourishing oils, and essential bodily fluids to deliver long-lasting health benefits in an easy-to-use product.

14. Medterra Pain Relief Cream

Image courtesy Medterra

Medterra uses full-spectrum CBD extracts in its pain relief cream to relieve all sorts of aches and pains, including arthritis, cramps & spasms, backaches, muscle soreness, and other types of pain.

15. Naternal CBD Salve

Image courtesy Naternal

Naternal makes a CBD-infused salve that you can use to soothe aches and pains. The formula specifically targets restless leg syndrome, which is why it’s called RLS Salve. Even if you don’t have restless leg syndrome, the ingredients are powerful enough to provide relief from other types of pain associated with backaches, muscle soreness, and more.

16. NuLeaf Naturals CBD Salve

Image courtesy NuLeaf Naturals

NuLeaf Naturals uses organic hemp oil to create a CBD salve that’s designed to target pain. The cream works for all types of skin, including dry skin, dehydrated skin, and damaged skin. It can even be used as part of an overall skincare routine.

17. Pure Hemp Isolate

Image courtesy Pure Hemp

Pure Hemp Isolate offers a broad range of pain relief products, including also CBD-infused oil. The company uses full-spectrum hemp extract in its formula to deliver fast results.

18. R+R Medicinals Cream

Image courtesy R+R Medicinals

R+R uses CBD-infused oil to create its cream. It’s made with all-natural ingredients and it can be used on all sorts of skin types, including dry, oily, acne-prone, and sensitive skin. The cream is effective at relieving pain associated with arthritis, backaches, migraines/headaches, and more.

19. Spruce CBD Oil

Image courtesy Spruce

Spruce makes CBD oil that you can use for all sorts of pain, including arthritis, joint pain, muscle aches, and nerve pain. The formula uses pure hemp extract to deliver full-spectrum benefits.

20. Vertly CBD Lotion

Image courtesy Vertly

Vertly CBD Lotion uses a blend of coconut oil and hemp extract to create a pain-relieving lotion. The main ingredient in the cream is full-spectrum CBD, which provides an all-natural way to soothe aches and pains.

21. CBDfx Muscle and Joint Cream

Image courtesy CBDfx

CBDfx muscle and joint cream is designed to target pain associated with arthritis, cramps and spasms, backaches, muscle soreness/stiffness, neck/shoulder/low back pain, and more. The formula combines CBD oil with natural ingredients to work as one of the best CBD creams for restless leg.

How to Use CBD Creams for Restless Leg Syndrome?

CBD creams are easy to apply on your skin. Just follow these simple steps:

● Wash your hands with soap and warm water before you begin.

● Apply a small amount of CBD topical cream to the affected areas of your body.

● Rub it in gently for about 1 minute.

● Allow the formula to absorb into your skin before putting on your clothes.

● It’s important not to wash off the lotion if you are using it for pain relief because washing will remove the oil from your skin, and you don’t want to lose it.

Pro Tip: You can also use the creams for pain relief on other parts of your body, such as your shoulder or back. Just make sure you keep the cream away from your eyes and mucous membranes. Don’t apply it to red, irritated skin.

What else can CBD creams be used for?

CBD creams for restless leg can be used for a variety of ailments and symptoms. Not only can you buy one of the 21 best CBD creams for restless leg for relief, but you can use these CBD creams for:

Relieving joint and muscle pain.

CBD cream has anti-inflammatory properties and provides a soothing sensation on your skin. Many of the top brands use coconut oil in their formulas to reduce inflammation, fight off free radicals, and speed up the recovery process.

Fighting excessive itching sensations.

If you get restless leg syndrome, CBD creams can reduce the intensity of itching sensations in your legs. Some people have been using CBD cream to fight against itchy skin associated with psoriasis and other types of dermatitis.

Reducing eczema and psoriasis symptoms.

Eczema and psoriasis can be incredibly uncomfortable and irritating. CBD cream, on the other hand, is incredibly soothing on your skin. Some people with these skin conditions use CBD cream to reduce the itchiness associated with them, while others use it for overall relief from inflammation.

CBD creams for restless leg can be used to relieve a number of different ailments and symptoms. The best CBD creams for pain relief use full-spectrum CBD in their formulas, which provides all-natural benefits and the highest potency possible.

Ways To Use CBD Creams For Restless Leg Syndrome

Different CBD brands sell their formulas in different ways. Here are the most common ways to apply CBD topical cream for relief:

Body Massages

Some people rub CBD cream onto their legs during body massages. This is a great way to get your muscles relaxed and prepared for a good night’s rest.

Just make sure you don’t use too much CBD oil, which can lead to the cream transferring onto your bedsheets.

Lotions And Oils

CBD creams for restless leg are best applied as lotions or oils. Just rub a small amount into your skin and allow it to absorb before putting on your clothes. Not only will this keep you hydrated throughout the day, but it’s an easy way to get relief wherever you need it.

Directly Into the Shoe

The simplest way to use CBD cream for restless leg is by rubbing some into your shoes before putting them on. If your legs are feeling particularly stiff or sore, rub some of the cream onto your muscles and joints.

The Pros and Cons of Using CBD Creams for Restless Leg

Before we wrap up this article, we wanted to share some of the pros and cons of using CBD creams for restless leg.

CBD creams for your legs provide you with all-natural pain relief and overall wellness. You can use it as needed or as part of your daily routine. It’s also made from full-spectrum CBD, which means that it contains all the benefits and properties of other types of cannabinoids like CBG and CBN.

Another pro of CBD creams for restless leg is that they are made with all-natural ingredients. This means that they won’t cause any irritation or side effects, unlike some prescription medications.

Some people find that CBD oil for restless leg is too greasy. This can make it difficult to get dressed if you’ve applied it directly to your skin. If this happens to you, try mixing the cream with other types of moisturizers or oils before applying them to your body.

Another con of using CBD cream for restless leg is that it can be difficult to find a good brand that fits your needs. Not all CBD creams are created equal, and some may not have the same effects as others. Do your research before you buy, and make sure to read reviews from other customers.

How CBD Creams for Restless Leg Compare to Other Treatment Options

While CBD cream is a good choice for restless leg syndrome, it’s not the only option you have. Prescription medication and over-the-counter solutions are also available to treat RLS symptoms.

Using a prescription drug for restless leg syndrome is a good idea if you need immediate relief. However, there are some risks involved with using these medications, and they’re not for everyone. Some of the prescription drugs used to treat RLS include:

The downside of using prescription medication for RLS is the side effects. These drugs tend to make people drowsy, which can interfere with their daily activities. They can also pose a risk for people with a history of lung disease, heart problems, glaucoma, and stomach ulcers.

Over-the-counter medications are another popular choice for restless leg syndrome treatment. The main ingredients in these medications include nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen. Other options may also include vitamins or sedative medications.

You can also use lifestyle changes to treat RLS. This includes making small adjustments in your daily routine that promote better sleep and overall wellness. If you’re looking for natural treatment options, try improving your diet with foods high in magnesium, exercising regularly, practicing relaxation techniques like meditation or yoga, and getting enough sun exposure every day.

Using CBD Oils and Creams for Restless Leg Syndrome

CBD oils and creams are one of the best treatment options for restless leg syndrome. They can provide your legs with soothing relief, which means you’ll be able to sleep better at night and perform daily tasks with ease.

This is a great way to improve your life and overall health and wellness. Just remember to use CBD creams and oil for leg pain as directed on the packaging, and only try out new products after consulting with your doctor or another healthcare professional.