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Best CBD Oil for Pain Relief & Inflammation: Highest Quality Brands On The Market

Over the past three years, CBD oil has become increasingly popular as a health and wellness supplement.

One of the main reasons people are interested in trying CBD oil is because of its pain-killing benefits. We’ll get into the details of how CBD is suggested to help with pain later, along with some suggestions for the best CBD oils for pain and inflammation.

The ability for CBD to help with pain is a significant advantage over conventional pain management options — which often involve addictive and potentially harmful medications. Instead, this natural supplement has very few side effects and an exceptional safety profile — all without compromising on effectiveness.

But how do you choose the right CBD oil for the job?

This is an important question to ask because the truth of the matter is that not all CBD oils work. Many simply contain too little CBD to be of any help, while others contain harmful contaminants like heavy metals, pesticides, or chemical solvents — all of which could add to the pain you’re already experiencing by damaging the sensitive nerve cells around the body.

We’re going to cover all of this in the article below. You’ll learn how to spot a high-quality CBD oil and how current evidence shows CBD to work inside the body.

This is a big topic, so let’s get started with our list of top-rated CBD oils for pain.

Top 10 Best CBD Oil Brands for Pain Management in 2022

Not sure which CBD oil to buy to help with chronic pain? Before we get into the nitty-gritty of how CBD is suggested to work for pain and inflammation, here’s our top 5 list of CBD oils I’ve used myself for back pain.

We’ll also offer some advice on a few ways you can spot a trustworthy CBD vendor even if they didn’t quite make it onto our list.

I’ve been using CBD for over 5 years now and I’ve stumbled upon some stellar companies with top-notch oils and fly-by-night businesses with oils that can’t simply don’t work.

I have a relatively short list of CBD brands that I fully trust and I want to share my choices with you so you can avoid some of the headaches and disappointment I’ve already endured.

Here are my top 10 CBD oil brands for pain:

1. Royal CBD (Best CBD Oil On The Market)

Technical Details
Total CBD Content 250 – 2500 mg
Available Flavors Natural, Mint, Vanilla, Berry
Potency 8.3 – 83.3 mg/mL

Get 15% off all Royal CBD products. Use code “CFAH” at checkout.

Why Royal CBD is My Top Pick:

As skeptical as I am towards the majority of new CBD brands, I decided to give Royal CBD a try because I liked the company’s dedication to quality. I love seeing companies that take what they do seriously.

You can tell right away from the color, flavor, and consistency of the oil that you’re dealing with a product well above average.

This oil is cheaper than most of the other premium CBD oils I’ve tried, comes in a full range of potencies, and uses some of the best full-spectrum hemp extracts I’ve ever seen. I’ve heard friends using this brand for quite some time and decided to give it a try for myself — so I ordered a few bottles in different strengths.

After taking the Royal CBD’s 2500mg full-spectrum CBD oil for just over a week, I noticed an improvement in my back pain. There was a time when I had serious problems falling asleep because of the sharp pains in my back that seemed to intensify whenever I laid down to fall asleep. It was a nightmare. I’d lay awake for hours changing positions to try and find a spot that didn’t leave me writhing in discomfort.

With this oil, my experience went far beyond what I expected. Not only did it help ease the pain, but my overall quality of sleep improved. I mean, I didn’t sleep longer but I began to wake up rested and with a clear head.

My favorite combination for this particular oil is the vanilla in the 1000 mg bottle. This is the largest potency option currently offered by Royal CBD and has the best value overall. I took the oil twice per day, once in the morning when I woke up, and again in the evening before bed. One bottle of the 1000 mg CBD oil lasted me about a month.

  • Sourced from US-grown organic hemp
  • Extracted with supercritical CO2
  • Contains the full spectrum of cannabinoids and terpenes
  • Available in 4 different strengths
  • Up to 2500mg of CBD per bottle
  • Lab-tested for potency and purity
  • Great natural flavors (no aftertaste and comes in multiple flavor options)
  • Free shipping within the USA
  • Newer brand on the market that only sells online, no physical presence

2. Gold Bee (Best Organic CBD Oil)

  • Premium Colorado-grown hemp
  • CO2 extraction
  • Contains full-spectrum CBD
  • Delicious kiwi flavor
  • Sweetened with organic honey
  • Lab-tested for potency and purity
  • Only one flavored option available
  • No high-strength oils (yet)

What I Like About Gold Bee:

I honestly believe Gold Bee makes the best organic CBD products out there. The brand combines premium Colorado-grown hemp with organic honey sourced from the Brazillian Rainforest. While Gold Bee offers a modest selection of oils — with up to 1200 mg of CBD per bottle — the formula is spot-on when it comes to the quality of ingredients. I’m totally not going to complain about the potency, as my back pain and sleep quality got better than with some high-strength oils I’ve tried in the past. Considering the quality of these products, they actually come at a bargain price. If you want to try other formats from Gold Bee, you can choose between its high-strength capsules and CBD-infused honey.

3. CBDPure (Runner Up)

Technical Details
Total CBD Content 100 – 600 mg
Available Flavors None
Potency 1.6 – 10 mg/mL
What I Like About CBDPure CBD Oil:

I love how transparent this company is. If I were judging companies solely by their transparency level, CBDPure would have scored the second place, right after Royal CBD. The company provides all the details about each stage of production when making this CBD oil. You can find all the third-party lab test results for each batch on the product page — something we’ve come to expect from any high-quality CBD company.

What really makes this company stand out is its incredible satisfaction guarantee. If you order the product and decide it wasn’t working for you, simply send it back and get a full refund. This satisfaction guarantee extends over 3 whole months — which is about three times longer than the industry average.

I keep a bottle or two of CBDPure oil in my medicine cabinet for achy moments after a run or hike with the kids.

The only real downside to this oil is the potency — which comes in denominations of 1.5, 5, and 10 mg/mL. This is suitable for more minor symptoms, but may not be enough for people with heavy CBD demands.

  • Sourced from Colorado-grown organic hemp
  • Extracted with supercritical CO2
  • Tested for the cannabinoid content and purity in a third-party lab
  • Rock-solid 90-day return policy
  • Narrow product range
  • Low potency
  • They don’t ship to every state (i.e. Louisiana, Indiana, Arkansas, Kansas)

4. HempBombs

Technical Details
Total CBD Content 300 – 4000 mg
Available Flavors Unflavored, Acai Berry, Orange Creamsicle, Peppermint, Watermelon
Potency 10 – 133.3 mg/mL
What I Like About HempBombs:

I used HempBombs CBD isolate-based hemp oil for quite some time before switching to full-spectrum CBD oil and in my opinion, this is the best brand when it comes to CBD isolates. Their products contain 99% pure CBD and ZERO THC.

Now don’t get me wrong, CBD isolates are great, they offer consistent doses of CBD, contain 0% THC, and are generally cheaper than their full-spectrum counterparts. In most cases, I like using a full-spectrum extract like Royal CBD oil because of something called the entourage effect — which is a concept highlighting the phenomenon where cannabinoids like CBD tend to work better when other hemp-derived compounds are also present.

In isolates, the only cannabinoid present is CBD.

HempBombs CBD oil is available in five different strengths — from 300mg to 4000mg per bottle. The CBD is added in the form of a 99% pure isolate — which means there’s going to be virtually no traceable amounts of any other cannabinoids, including THC, CBC, CBG, or CBN.

You can also buy these oils in different flavors. Hemp Bombs often adds new flavors to the list, but my all-time personal favorite is the Acai berry. It’s not too sweet but adds a really pleasant flavor to the otherwise bland CBD and MCT oil formula.

  • Sourced from 100% certified organic hemp from European farms
  • Extracted with supercritical CO2
  • Completely THC-free
  • Tested in third-party laboratories for purity and potency
  • Available in 5 separate strengths
  • Up to 4000mg of CBD per bottle
  • Lacks the synergistic effects from other cannabinoids
  • The highest potencies are overkill for most users
  • Uses synthetic flavoring agents

5. CBDistillery

Technical Details
Total CBD Content 250 – 5000 mg
Available Flavors None
Potency 8.3 – 166 mg/mL
What I Like About CBDistillery:

CBDistillery is now one of the largest CBD companies in North America. The company began in 2016 as a legacy brand for Balanced Health Botanicals.

Over the years, CBDistillery has had the chance to really dial-in its CBD oil formula. The company now sells its CBD oil in two formats — “full-spectrum” and “THC-free.” The THC-free option is great for people who want to benefit from the synergy of CBD and other cannabinoids but without bringing any THC whatsoever into their system.

Even the full-spectrum option contains less than 0.3% THC — which is well below the amount needed to cause any psychoactive effects. These oils are both completely non-psychoactive.

You can choose between five different strengths, starting at 250mg up to 5000mg of CBD per bottle. This covers just about every range of potencies you would ever need. We recommend opting for the higher potency options because they have the best value overall. The higher potency you purchase, the further your dollar gets you.

The more potent options also las the longest because you need smaller amounts of the oil each time to get the desired dose of CBD.

I tried the 1000mg bottle to keep myself calm during the first few months after giving birth to my first son and I must admit it helped me maintain my sanity during that time. I found it to have a remarkable calming effect on the body and mind.

  • Available as full-spectrum CBD or pure CBD oil (THC-free)
  • 5 strengths to choose from
  • Carries up to 33.3 mg of CBD per mL (in the 1000 mg bottle)
  • Excellent value CBD oil
  • The hemp isn’t certified organic
  • No flavor options available
  • The company website is clunky and hard to navigate

6. NuLeaf Naturals

Technical Details
Total CBD Content 240 – 4850 mg
Available Flavors None
Potency 48.5 mg/mL
What I Like About NuLeaf Naturals

Nuleaf Naturals is one of the most popular CBD companies in the United States — most likely related to how long the company has been in the business of selling CBD. Nuleaf naturals were one of the first CBD companies to enter the mainstream market.

Despite the companies longstanding reputation, Nuleaf Naturals only sells one CBD oil. When you go to the website you’ll find a few different options, including a pet oil — but it’s important to understand that these are all the exact same full-spectrum extract, the only difference is the bottle sizes.

We love the simplicity of Nuleaf Naturals product lineup. The oils come with a decent potency of around 48 mg/mL, and just about every bottle size you can imagine. This makes it easy for everybody to find a product that works for them regardless of the budget.

With that said, if you have the cash, we highly recommend getting the larger bottle sizes in order to get the best value for your money.

You can choose between five different sizes:

  • Sourced from organic Colorado-grown hemp
  • Extracted using supercritical CO2
  • Made from a full-spectrum hemp extract
  • More expensive than the other brands in this ranking
  • Narrow product range

7. Charlotte’s Web

Technical Details
Total CBD Content 200 – 1800 mg
Available Flavors Mint Chocolate, Lemon Twist, Orange Blossom, Olive Oil
Potency 7 – 60 mg/mL

About Charlotte’s Web:

Charlotte’s Web is one of the pioneers in the American CBD industry. Established by the Stanley Brothers, the company has coined a reputation of a trustworthy manufacturer by helping now late Charlotte Figi with her treatment-resistant epilepsy. Although the company has recently received a warning letter from the FDA due to their health claims, they still have many faithful customers and a massive number of positive reviews on the web.

Charlotte’s Web CBD oil comes in several potencies: 200 mg, 500 mg, 1500 mg, and 1800 mg of CBD per bottle. The highest strength offers 60 mg of full-spectrum CBD per milliliter. There are two bottle sizes to choose from: 30 mL and 100 mL; Charlotte’s Web also has flavored variants of its CBD oil, including Lemon Twist, Orange Blossom, Mint Chocolate, and Olive Oil.

What could the company do better?

First off, they could change their extraction method because they use ethanol, which is less efficient than CO2 extraction. Secondly, and most importantly, the suspension in olive oil makes them taste a bit bitter — even in the flavored versions.

Pros:

  • One of the most reputable brands on the market
  • Full-spectrum CBD
  • Delicious flavored versions
  • Up to 1800 mg of CBD per bottle
  • Available in two sizes: 30 mL and 100 mL
  • Third-party tested for potency and purity

Cons:

  • Non-organic hemp
  • Ethanol extraction
  • Suspension in olive oil (bitter taste)
  • The company received a warning letter from the FDA in the past due to inappropriate health claims

8. cbdMD

Technical Details
Total CBD Content 300 – 7500 mg
Available Flavors Natural, Berry, Orange, Mint
Potency 10 – 250 mg/mL

About cbdMD:

cbdMD is another popular manufacturer that offers a wide range of CBD extracts, from tinctures to gummies to capsules, bath bombs, topicals, sleep aids, and pet products.

The brand offers a wide range of pure CBD oils, with up to 7500 mg of CBD per bottle. The highest potency comes with a whopping dose of 200 mg of pure CBD suspended in MCT oil for higher bioavailability and a smoother flavor. cbdMD also has three flavored CBD oils: Berry, Orange, and Mint.

Despite an impressive potency range, cbdMD uses broad-spectrum CBD in their products, which doesn’t evoke the full entourage effect. The higher potency may not necessarily mean better results in this case.

The company has high transparency standards; not only does cbdMD broadly describe their activity from farming to testing, but they also provide batch-specific certificates of analysis for their products, including the results for potency and common contaminants like pesticides, heavy metals, and residual solvents.

Pros:

  • US-grown, non-GMO hemp
  • CO2 extraction
  • THC-free
  • Up to 7500 mg of CBD per bottle
  • Batch-specific certificates of analysis

Cons:

  • Limited entourage effect due to the lack of THC
  • Most people don’t need such high doses of CBD in their routine

9. Medterra

Technical Details
Total CBD Content 500 – 3000 mg
Available Flavors Natural, Citrus, Mint Chocolate
Potency 16 – 100 mg/mL

About Medterra:

Medterra is a small craft company from California. The brand offers premium CBD oils in different spectra: full-spectrum CBD, broad-spectrum CBD, and isolates. The potency of these products ranges between 500 mg and 3000 mg of CBD per bottle, which is a standard range. On top of the unflavored version, there are two flavored options: Citrus and Chocolate

Medterra prides itself on making the real full-spectrum CBD because each bottle of its full-spectrum CBD oil comes with 2 mg of THC. However, these products are only legal in the states that have legalized higher amounts of THC for recreational use. So, if you want to buy the company’s products in all 50 states, your options are limited to broad-spectrum CBD and CBD isolate. These provide more CBD per bottle — upwards of 1000 mg.

The entire Medterra’s product range is tested in a third-party laboratory for their CBD content and safety.

Pros:

  • Premium-grade CBD oils
  • Up to 3000 mg of CBD per bottle
  • Available as full-spectrum CBD, broad-spectrum CBD, and isolates
  • Lab tested for potency and purity

Cons:

  • The “real” full-spectrum CBD oil isn’t available in all states
  • Some of the lab reports indicate higher CBD levels than stated on the bottle
  • No discounts for returning customers

10. Joy Organics

Technical Details
Total CBD Content 450 – 900 mg
Available Flavors Tranquil Mint, Fresh Lime, Summer Lemon
Potency 15 – 30 mg/mL

About Joy Organics:

Joy Organics holds the reputation of one of the most reputable CBD vendors in the industry. The company was established by a woman named Joy Smith, who has been using CBD oil to manage her problems with pain and sleep. After experiencing the benefits of CBD first-hand, she has decided to share her passion for cannabis with other health-conscious consumers.

The brand sells a range of broad-spectrum CBD products from certified organic hemp. They have many positive reviews all over the Internet; they also haven’t received any warning letter regarding health claims from the FDA — unlike many companies in this space (even the veterans like Charlotte’s Web).

The Joy Organics CBD oil features a broad-spectrum CBD formula in a modest potency range, from 450 to 900 mg of CBD per bottle. You can choose from three refreshing flavors: Summer Lemon, Fresh Lime, and Tranquil Mint. The strongest version of the Joy Organics CBD oil contains 30 mg of broad-spectrum CBD in every milliliter, which is a standard dose for most people who take CBD oil for daily supplementation.

In 2018, one of the company’s flavored CBD oils was found to contain a fungicide that is commonly sprayed on citrus fruit during independent lab testing. Fortunately, Joy Organics recalled the product shortly after this incident and implemented a new third-party testing system to make sure there are no flaws in the end product.

Pros:

  • Non-GMO, US-grown hemp
  • Supercritical CO2 extraction
  • Broad-spectrum CBD
  • THC-free
  • Delicious flavors

Cons:

  • A bit expensive
  • No high-strength oils

CBD Oil for Pain Management: Complete Guide for Beginners

Now that we’ve covered a few CBD oil options that are going to provide the best value for your money, let’s discuss how CBD is suggested to support chronic pain in the first place. We’ll also cover some of the most common ways people are using CBD oil for pain.

What is CBD Oil?

CBD stands for cannabidiol _ it’s one of the primary active ingredients in the cannabis plant. It’s completely non-psychoactive and offers a wide range of benefits to the human body.

CBD oil is a combination of a CBD extract, with a carrier oil to help dissolve and store the CBD. Most CBD oils use carrier oils like MCT oil, or hemp seed oil — which is then combined with CBD isolate, or full-spectrum hemp extract rich in CBD and other similar cannabinoids.

Cannabinoids like CBD are fat-soluble — which means they dissolve when mixed with oil, but won’t dissolve in water. By dissolving these compounds in an oil solution, the CBD becomes much easier to store and use. Instead of measuring out micrograms of CBD crystals or hemp resin, all you need to do is measure oil to get your dose of CBD. This can be done using a simple dropper that comes standard with most CBD oils.

Because of their ease of use, and long shelf-life, CBD oils have become the go-to method of using CBD and other hemp extracts.

You can also opt-out to use CBD-infused gummies if you wanted something discreetly, read our in-depth review on CBD Gummies to understand better.

How Does CBD Work?

Cannabis has been used for managing pain and inflammation for thousands of years.

The earliest records of the medical use of the herb date back to ancient China when the emperor Shen-Nung placed it among other therapeutic substances in the Chinese pharmacopeia (1). The leaves were wrapped around an injury as a poultice to reduce pain and discomfort, and reverse swelling and bruising.

Despite being a known medicine for a long time, scientists have only recently begun to unlock the mechanisms cannabis uses to achieve its important pain-killing benefits.

Since the discovery of the endocannabinoid system in 1992, CBD and other phytocannabinoids have been in the spotlight of modern medicine.

The endocannabinoid system is one of the most important neurochemical networks in the human body (2). It works by interacting with the endocannabinoid system — a series of hormones and receptors that help regulate over a dozen core processes in the human body. The active compounds in the cannabis plant are very similar to the naturally-produced hormones involved with our endocannabinoid system.

By interacting with the endocannabinoid system, CBD and other cannabinoids are able to modulate several key processes, such as:

  • Appetite
  • Immune function
  • Memory
  • Mood
  • Stress
  • Sensory perception (including pain)
  • Inflammation
  • Reproductive health
  • Nerve function
  • Sleep

How Can CBD Reduce Pain Transmission?

How does all of this relate to pain? The answer lies in the way pain is transmitted to the brain.

When we injure ourselves, cells in the immediate vicinity begin releasing compounds that trigger a cascade of inflammation and sensory activation — which is what triggers the pain transmission.

The pain signal is then sent to the spinal cord through a network of nerves distributed all around the body.

Once in the spine, the pain signal is sent through a gateway (opioid and vanilloid receptors) designed to limit the amount of signal that ends up in the brain for processing. This works like a border crossing. The border security decides whether or not you’re allowed to enter and what you can take with you.

In the context of pain, these gateways can limit the amount of pain signal that continues across the border to the brain. If more pain signal is allowed to pass, the brain perceives more pain. If the pain is stopped at the border, the brain perceives less pain.

Conventional pain medications work by activating the opioid receptors acting as a key gateway for pain transmission to the brain.

CBD has a similar effect, but through a different receptor is known as the vanilloid receptors. These vanilloid receptors are tasked with regulating a specific form of pain caused by either heat or inflammation. CBD has been reported to modulate this vanilloid receptor — leading to a reduction in the pain signals sent to the brain from inflammatory causes such as arthritis, muscle damage, or infection, to name a few.

CBD has other ways it can limit pain transmission as well:

  • CBD may reduce inflammation, limiting the initial cause of pain in the body
  • CBD acts as an antioxidant, helping the body resist and recover from damage
  • CBD relaxes muscle fibers, reducing pain caused by muscle spasms and tightness

More research is needed to fully understand how CBD and other active cannabinoids can block pain. Every year dozens of new research papers are published in an attempt to paint a clear picture of how CBD works, how to get the most benefit from the supplement, and what its limitations are.

(Pain Transmission Pathway to the Brain)

Choosing CBD Oil Companies: How to Differentiate the Good From the Bad

CBD has become a lucrative business. Companies are selling a myriad of different CBD oils and other products in an attempt to cash in on the new health trend. This means there are a lot of excellent products coming to market, but it also means there’s a lot of trash as well. It’s important as a CBD user that you understand what makes a CBD oil good, and what makes it bad so you can avoid wasting your money, or worse — using CBD oils that contain harmful or damaging ingredients.

Let’s cover the most important points to remember when shopping for CBD oil online or in-store.

1. Check the Hemp Source

The source of the hemp used to make the oil is vitally important when it comes to determining which CBD oils are the best. The main reason comes down to the botany of the hemp plant itself.

Hemp is a bio-accumulator — which means it has the tendency to absorb compounds from the soil and accumulate them in its leaves, stems, and roots. The deep taproots of the hemp plant stretch far beneath the soil, pulling out and storing all the heavy metals and other elements it can find in the soil.

This aspect is in part why hemp is so nutritious, but it also means that plants grown in contaminated soils often contain contaminants that can be harmful to your health. Some of the worst offenders are heavy metals — which can build up in the body over time and lead to severe long-term health effects.

You want to avoid consuming heavy metals at all costs.

Poorly grown hemp could contain heavy metals, as well as other contaminants like mycotoxins, or pesticide residues that will end up in the CBD oil after all the processing is complete.

For this reason, it’s important to purchase CBD oil from companies that account for this effect. Only buy from company’s that make an effort to source hemp from organic farms, and take measures to assess every batch of hemp that enters the facility to determine heavy metal, microbial contaminant, and pesticide contamination.

The best hemp sources tend to come from states like Oregon, Colorado, or Alabama, as well as neighboring countries like Canada or Scandinavian countries. These places are all known for having high standards for hemp cultivation, and clean soils.

2. Look for CO2 Extracted Products

Once the company has the hemp, they need to extract the CBD from it. You can do this in many different ways using solvents like ethanol, methanol, hexane, ether, or butane. All of these solvents work to strip the active compounds from the hemp plant and can then be evaporated to leave behind a pure CBD-rich resin.

however, there’s a problem with these solvents.

Even in professional lab settings, it can be very difficult to remove all traces of these solvents from the final product. Most of these solvents are toxic to the human body, even in trace amounts.

Therefore, the best companies are using another method to strop the active ingredients from the starting hemp material. This method uses CO2 placed under high pressure. the high pressure and temperature control convert the CO2 into a phase that’s neither liquid nor gas. This special state is referred to as being supercritical.

Supercritical CO2 acts just like any other solvent, but with one key benefit — as soon as the pressure is relieved, the gas evaporates completely, leaving behind no harmful chemical residues.

when shopping for CBD oil, it’s ideal to look for a company that uses supercritical CO2 to extract the CBD rather than the toxic solvents mentioned above. Supercritical CO2 is very expensive and highly technical — but usually produces a far superior product in the end.

If a company is using harsh solvents like butane or propane (or they don’t tell you anything about their extraction methods), it’s a sign that you should look for another brand.

3. Ask for Third-Party Lab Reports

Every company has the option to send their products to an independent lab or third-party testing.

These laboratory tests check for the entire cannabinoid profile of the extract and are able to detect over 200 common contaminants.

Before a CBD product becomes available for sale, it should pass the laboratory test for potency and purity. If any inconsistencies are shown between different batches of the same product, the company should rework it and send it for analysis once again.

High-quality CBD companies will continually send each batch of product to a lab with no affiliation to the company (called a third-party or independent lab) for testing. These results are then published publicly on the website for customers to view.

The best companies will take this even one step further — adding a database and batch numbers on every bottle of CBD oil so you can view the results for your specific bottle of oil. Third-party testing is now an industry standard.

Always buy your CBD oil from companies that show third-party lab reports on their website. Only then will you know what’s inside the bottle before you even order a product. If the company is producing CBD oil that’s as high quality, as they say, there should be nothing to hide in these lab tests and they should be listed publicly on the company website. If you can’t find them on the site, you can ask customer service for these as well.

If these tests don’t exist, or you can’t track them down from the website or customer service — it’s best to avoid this company and move on to another that takes this important step seriously.

What the Research Says About Using CBD Oil for Pain:

Understanding how CBD works is no simple task. This compound is incredibly complex — working through a number of unrelated receptors around the body, interacting with enzymes, cell membranes, and various other cell structures. This makes studying CBD very difficult.

Nevertheless, there have been thousands of research papers published on medical marijuana — seeking to understand the interaction between cannabinoids like CBD and the human body. A lot of this research specifically focused on the effects of CBD on various forms and causes of pain. Let’s explore some of the results this research has yielded in the context of pain management.

1. CBD Oil for Chronic Back & Nerve Pain

The painkilling properties of cannabidiol have been most thoroughly studied in animal models, as well as a handful of human clinical trials.

One of the best studies we have available on the topic is a meta-analysis published in 2017. This analysis looked at 24 different clinical trials involving 1,334 patients over several years and demographics. These studies all used various forms of cannabis for treating chronic pain. The analysis reports that many of these studies showed a reduction in chronic pain scores by 50% or more (3) — suggesting the cannabis plant to be a potential treatment for chronic pain.

Another clinical trial looked at the effects of a combination of CBD to THC in the treatment of intractable cancer pain. This study found that twice as many people in the treatment group given CBD and THC had a 30% or more reduction in pain symptoms at the conclusion of the trial (6).

Even though more clinical trials on humans are needed to gauge how CBD affects specific forms of pain or other conditions, scientists believe the efficacy of CBD in treating chronic pain is related to its anti-inflammatory effects (3).

2. CBD Oil for Arthritis

CBD has had a lot of research as a potential alternative to prescription and non-prescription pain medications commonly used for alleviating arthritis pain.

Researchers have found a clear link between the endocannabinoid system and the pathophysiology of osteoarthritis, which is a degenerative joint disease associated with chronic pain and inflammation (4).

One of the key areas CBD is thought to support osteoarthritis specifically is through the effects on an enzyme known as 5-lipoxygenase — AKA 5-LOX. CBD has been shown to inhibit this enzyme (7), which converts fatty acids into pro-inflammatory compounds. These inflammatory messengers have been shown to be a key component in the underlying inflammation involved with osteoarthritis (8).

By reducing the underlying causes of arthritis pain, CBD is thought to reduce the overall burden of pain from the condition over the long term.

3. CBD and Multiple Sclerosis (MS) Pain

Due to its antioxidant and anti-inflammatory properties, CBD is a potent neuroprotective — which is how experts believe CBD is able to relieve debilitating MS pain, —which affects roughly 50–70% of patients diagnosed with the condition.

A study conducted on animals at Cajan Institute tested the anti-inflammatory effects of CBD on mice the researchers wanted to find out if CBD can provide a reversed inflammatory response on those cells. After ten days, the researchers found a reduction in inflammatory markers with a rodent encephalitis model designed to imitate the impact MS has on the body (5).

More research is needed to see exactly how these effects are translated to humans. Currently, there are 23 clinical trials currently underway, or planned within the next 12 months seeking to explore the effects of CBD on MS.

4. CBD Oil in Sports: Injuries & Muscle Endurance

Cannabidiol can be applied in two different ways when it comes to pain and physical activities. For example, when you administer CBD orally in the form of oil as a post-workout, it helps alleviate the muscle inflammation that troubles athletes once they go beyond the edge again.

If, however, you’re suffering from an injury, it’s best to apply CBD topically. Its anti-inflammatory and neuroprotective properties allow the cannabinoid to relieve pain and improve regeneration capacities.

Does CBD Have Any Side Effects?

The main reason why parents are so enthusiastic about CBD is that this cannabinoid is completely non-intoxicating, doesn’t cause addiction, and has only a few mild side effects when taken at excessive doses.

Research shows that even doses up to one and a half grams have no severe side effects on human health (9).

Despite being a notoriously safe supplement, there are some side effects of using CBD in high doses. Let’s cover the most common side effects people report from using CBD:

  • Anxiety
  • Brain fog
  • Reduced appetite
  • Mood changes
  • Diarrhea or constipation
  • Dizziness or lightheadedness
  • Drowsiness or fatigue
  • Dry mouth
  • Nausea and vomiting

The most common side effect by far, like other forms of cannabis, is dry mouth. This is best managed by taking your CBD oil along with some juice like pineapple or orange juice.

Another common side effect is lowered blood pressure, which may trigger another unwanted reaction — lightheadedness. This side effect is important to consider if you suffer from low blood pressure already or are taking blood pressure-lowering medications.

Always consult your doctor before using CBD or other cannabis extracts if you’re taking prescription medications or have underlying medical conditions.

In Summary: Buying CBD Oil For Pain

As CBD becomes more popular around the world, scientists are publishing new research on cannabinoids on a near-weekly basis. As time goes on, experts are mapping out the complicated mechanisms CBD and other hemp derivatives are using to support both acute and chronic pain of all different origins.

Here are the main takeaways from the current research:

  • CBD inhibits inflammation at several different levels
  • CBD offers antioxidant support
  • CBD may relieve muscle tension and inflammation
  • CBD interacts with the vanilloid receptors in the brain responsible for regulating inflammatory pain transmission

When it comes to pain, CBD appears to target the cause of the problem instead of just masking its symptoms.

Getting relief on so many levels and without any harmful side effects or risk of addiction is the reason why CBD oil has become so popular over the past half a decade.

I hope this guide has managed to clear up any confusion regarding CBD oil and pain, and given you the insight necessary to find the right CBD oil for the job.

Have you tried CBD oil for chronic pain? Did you feel any difference? Let me know in the comments below!

References:

  1. Brand, E. J., & Zhao, Z. (2017). Cannabis in Chinese Medicine: Are Some Traditional Indications Referenced in Ancient Literature Related to Cannabinoids?. Frontiers in pharmacology, 8, 108.
  2. Alger B. E. (2013). Getting high on the endocannabinoid system. Cerebrum: the Dana forum on brain science, 2013, 14.
  3. Aviram, J., Samuelly-Leichtag, G. (2017) Efficacy of Cannabis-Based Medicines for Pain Management: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Pain Physician, 20(6), E755-E796.
  4. Bruni, N., Della Pepa, C., Oliaro-Bosso, S., Pessione, E., Gastaldi, D., & Dosio, F. (2018). Cannabinoid Delivery Systems for Pain and Inflammation Treatment. Molecules (Basel, Switzerland), 23(10), 2478.
  5. Elliott, D. M., Singh, N., Nagarkatti, M., & Nagarkatti, P. S. (2018). Cannabidiol Attenuates Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis Through Induction of Myeloid-Derived Suppressor Cells. Frontiers in immunology, 9, 1782.
  6. Johnson, J. R., Burnell-Nugent, M., Lossignol, D., Ganae-Motan, E. D., Potts, R., & Fallon, M. T. (2010). Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC: CBD extract and THC extract in patients with intractable cancer-related pain. Journal of pain and symptom management, 39(2), 167-179.
  7. Takeda, S., Usami, N., Yamamoto, I., & Watanabe, K. (2009). Cannabidiol-2′, 6′-dimethyl ether, a cannabidiol derivative, is a highly potent and selective 15-lipoxygenase inhibitor. Drug Metabolism and Disposition.
  8. Lascelles, B. D. X., King, S., Roe, S., Marcellin‐Little, D. J., & Jones, S. (2009). Expression and activity of COX‐1 and 2 and 5‐LOX in joint tissues from dogs with naturally occurring coxofemoral joint osteoarthritis. Journal of orthopaedic research, 27(9), 1204-1208.Chicago
Nina Julia

Nina created CFAH.org following the birth of her second child. She was a science and math teacher for 6 years prior to becoming a parent — teaching in schools in White Plains, New York and later in Paterson, New Jersey.

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Where to buy CBD oil, gummies, more for 4/20: 16 best companies of 2022

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Since 2022 is the year to try new things, better yourself and take the plunge into a wellness trend that has been going strong for almost a decade.

And on 4/20, the holiday celebrating the hemp plant that produces cannabis — maybe this year is the one to introduce CBD into your wellness routine.

CBD, an abbreviation for cannabidiol found in the hemp plant, is now incorporated into drink mixes, skin salves, bath bombs and even food and beverages. While booming in popularity, many are still unsure what CBD is, or if it is psychoactive like its cousin chemical, THC.

“It’s a naturally occurring substance that’s used in products like oils and edibles to impart a feeling of relaxation and calm,” according to a Healthline article explaining CBD. “Unlike its cousin, delta-9-tetrahydrocannabinol (THC), which is the major active ingredient in marijuana, CBD is not psychoactive.”

There are so many products on the market to try, and since the effects vary from person to person, it may be worth experimenting to find the most suitable products. You may come out feeling less anxious, more relaxed or worst case: with a new yummy drink mix or soothing lotion to use.

Also, in honor of the “holiday” many brands below are offering deals on their offerings, helping you celebrate all day and year long.

1. Just CBD, enjoy a store-wide BOGO sale on 4/20

This one is all in the name, and nothing else.

Just CBD is a one-stop-shop for your CBD needs with a full product range for everyone’s tastes and textures. If you want the latest drop, make sure to bookmark their Weekly Specials page for the most current offerings and sales on bestselling products. Right now, some fruity Strawberry Banana CBD Gummies are on sale for $13.99 and for the vegans out there, the Vegan Exotic Fruit Gummies and the Vegan Mixed Fruit Gummies are both on sale for $17.99. For those watching their sugar intake, they also have a sugar-free gummy that cuts the sugar, not the flavor.

If you don’t want to ingest your CBD and prefer a leisurely soak in the tub, be sure to find the bath bomb and soap section of the site. First take a long bath with a CBD Bath Bomb, available in relaxing scents like Rose, Lavender, Eucalyptus, Citrus and Sweet Cherry. Then, lather up with some Hemp Soap and then finish it all off with some lotion or massage oil.

2. Caliper, subscribe to save 10% and get free shipping

Take the guesswork out of how to dose your CBD intake with the flavored and unflavored powder packs from Caliper.

“There’s so much confusion about CBD in the market right now. With Caliper CBD, there’s never a question about the quality or dose of what you’re getting,” Caliper Foods co-founder and brand director, Missy Bradley said in an interview with The Post. “Not to mention the convenience of being able to mix it quickly and cleanly into any food or drink, hot or cold, including something as basic as a glass of water.”

The CBD brand has two easy-to-use products. The first is a 20-milligram unflavored packet to add to a glass of water or mix into food. The pack of 30 goes for $44.99 per month and can be ordered as a subscription so you never run out. As an added bonus, new Caliper customers can take 15% off their first order with code NYPOST15, exclusive to New York Post readers.

Caliper and all its ingredients are tested for quality by top third-party labs in the U.S., making sure each packet is properly dosed and of top quality and potency. As always, Caliper’s products are 100% THC-free, sugar-free, calorie-free, vegan, gluten-free and non-GMO.

The Caliper Swiftsticks is a pixie stick-like packet of flavored CBD to simply pour onto the tongue and enjoy. They come in a cool mint, mixed berry and a lemon-lime flavor, adding a perfect punch of flavor to your daily dose of 20 milligrams.

3. CBDistillery, free shipping on orders over $75

For a full range of CBD products, look no further than CBDistillery.

They carry CBD in almost every form, from traditional orally-ingested oils and capsules to topical creams and balms. If you are new to CBD don’t worry, as the site formulated a quiz to help you decide which product is right for you, asking you about your daily life, what you’re looking to achieve and how you prefer to take your daily dose.

If you’re shopping for someone who could use some TLC with CBD, make sure to check out their gifts section as well. There you’ll find even more tinctures, gummies and even a CBD Sample Pack with soft gels and gummies to get a little taste of everything.

4. Martha Stewart CBD

Martha Stewart cooked up another great idea, and you can bet it tastes amazing, too.

Martha Stewart’s line of CBD products combines the hemp plant’s offerings with her impeccable palate for flavors, making for a yummy gummy treat, or an oil if you prefer. Sold on Shop Canopy’s site, for those wanting to sample them all, check out the 15 flavor sampler pack, including delights like Persian lime, black currant and huckleberry to name a few fruity flavors. Each gummy contains 10 milligrams of CBD which takes the guesswork out of dosing and makes the whole experience that much more enjoyable.

If you’d rather partake with an oil than a gummy, you’re in luck, as the Martha Stewart CBD Oil Sampler is now on sale, with three tinctures of lemon, blood orange and unflavored oil for just $108 instead of the $135 ticket price.

If we’re barking up the wrong tree with human CBD products, Martha also has some special treats for your furry friends, with a whole line of pet-friendly products. For overall wellness, the chicken and blueberry treats come in a small and medium dog size as well as a dose for larger pups. There are also treats for mobility and calming, as well as an oil tincture if your dog will sit and stay to take it (or just drop the chicken-flavored oil in their dish of dog food.)

5. Recess, take 10% off with code SPRING

While many of us don’t miss the classroom, we sure could use a little more recess in our adult lives.

Recess is a sparkling water and drink mix company on a mission to make that a reality, taking a break in your day to sip on something sweet and infused with broad-spectrum hemp, in addition to adaptogens like American ginseng, lemon balm and L-theanine.

For sparkling drink fans, the flavors will tickle your tastebuds. They currently carry blood orange, peach ginger, pomegranate hibiscus, black cherry, coconut lime and blackberry chai, with 10 milligrams of hemp extract per can. For those that can’t decide, the sampler pack is your best bet, coming in a six-pack with one of each, or a 12-pack to share with a friend.

6. Fleur Marché, take 20% off with code FEELZ

Peel, stick and forget.

These CBD patches from Fleur Marché make using CBD so much easier topically and targeted to your needs for that moment. The patches come in four different colors and focus areas called “Sleep, Plz.,” “Energy, Plz.,” “Relief, Plz.” and “Sex, Plz.” Starting at just $6 for a patch, they contain 20 milligrams of CBD extract per patch and can be worn for up to 12 hours.

Stick them on the veiny part of your inner arm for best results and then go about your day. Sleep, Plz. includes melatonin, Energy, Plz. has B12, Relief, Plz. contains peppermint oil and menthol and Sex, Plz. has a blend of L-Arginine, Maca and Tribulus. For those that can’t decide, stick with the variety pack, which comes with either one or two of each depending on what you choose.

7. Lord Jones, get free shipping on all orders

Lord Jones is among the royalty of top CBD brands, offering a wide array of products in varying doses to treat every need.

To start, the classic supplements can be taken in either pill or liquid form, coming in a CBD gel capsule with 25 milligrams of CBD per pill. For those who prefer liquid drops, there are two more options for you: a 500-milligram bottle of full-spectrum CBD in a peppermint or orange flavor and a 250-milligram tincture of broad-spectrum CBD in a lemon or peppermint flavor.

Moving on to the topicals, there are too many to list, including a lip balm with 25mg of hemp-derived CBD per tube, and a high CBD formula bath salts jar, for warm baths of approximately 20 milligrams of CBD per bath or 240 in the whole container.

“Lord Jones Tinctures and Gel Capsules have been expertly crafted from simple ingredients. Our hemp-derived CBD oil retains the plant’s original terpenes and phytocannabinoids for broad and full-spectrum formulations. All Lord Jones products are lab-tested to ensure proper purity and potency,” reads the Lord Jones website.

Check out the gifts under $50 page, which includes favorites like the lip balm, as well as other gems, like the award-winning lotion and some gummy delights.

8. Sunday Scaries, take 25% off sitewide with code 420LIFE

Scare the scaries away with these CBD products from Sunday Scaries.

“Sunday Scaries are the feeling of stress, nervousness, and worry that many people experience on Sunday nights. They are the ping of fear that hits when you realize that the weekend is over and Monday is near — and it sucks!” reads the Sunday Scaries site.

The Vegan AF CBD gummies come in a rainbow of gumdrops inside a teal package. There are 20 gummies per pack, with 10 milligrams of CBD per gumdrop.

The brand also offers pre-made bundles of joy, combining top-selling products, merch and more into a discounted package. To rep the brand, check out the Everyday Scaries pack and get a bottle of the classic gummies plus a hat with an adorable gummy bear on it. For those who want CBD day and night, the bestselling Sidepiece Bundle is on sale now for just $43, down from $98, and comes with a bottle of gummies for the day and a tincture of CBD oil for nighttime.

9. Medterra, buy one, get one free sitewide with code 420

A brand great for bulk orders, Medterra is the place to go for oils, supplements, topicals and gummies, all made with 99% pure CBD, guaranteed to be THC-free in every batch.

“Although hemp cultivation, extraction and manufacturing is relatively new to the US, our team of experts and partners have dedicated their lives to industrial farming methodologies, food-grade compound extraction, vegetable genetics and quality control, just to name a few,” reads their about page.

A great idea for those still exploring CBD, check out their gummies, which are easy to take. “Sleep Tight” gummies taste like strawberries and contain 25 milligrams of CBD. “Stay Alert” gummies also contain 25 milligrams of CBD as well as green tea and Ginkgo Biloba.

Back to bulk, if you’ve moved past discovery and now want a steady supply of your favorites, Medterra offers both bulk orders and bundles. Check out their 12-pack of chewable CBD gum, with each piece containing 20 milligrams of CBD, in addition to nootropics L-theanine, L-tyrosine and vitamin B6. Or, bundle and save with a combination of two or more products from their lineup. Combine two and save 10%, three to save 15% and combine four or more products and save 20% on your entire order.

10. Foria

This company takes CBD out of the medicine cabinet and into the bedroom.

“As the first-ever cannabis and hemp brand in the sexual wellness space, it’s our joy and mission to offer effective organic and plant-based formulas for vibrant wellbeing – in and out of the bedroom. Our lines for intimacy, relief, and wellness have been changing lives since 2014,” reads the website.

Their offerings span three broader categories listed on their website, titled “intimacy,” “wellness” and “relief,” each with oils, topicals and other treatments with varying amounts of CBD in each. To start, the intimacy collection features a natural lubricant with CBD to be used topically to enhance the comfort and enjoyment of sexual activity and can be applied as needed. They also offer a “Get Wet” Set, a kit to share with a significant other or use on your own, featuring three full-sized bottles of the Awaken Arousal Oil, Intimacy Natural Lubricant with CBD and Intimacy Bath Salts with CBD and cacao.

11. Truly Beauty CBD Products

A cult-favorite TikTok beauty brand with over 19.9M profile views, Truly is also on the cutting edge of all things CBD, offering a lineup of bath and beauty products, now sold at Ulta Beauty.

Named after a strain of the harder stuff, the Blueberry Kush collection features a body scrub, body lotion, body oil and face oil, all sold at Ulta. The scrub, a bestseller from Truly overall, contains 300 milligrams of CBD, as well as blueberry seed oil to help detoxify skin and draw out impurities. The formula in all of the products is always vegan, as well as cruelty-free and never tested on animals.

“Our team of experts has worked and continues to work with physicians, microbiologists and world-renowned chemists to perfect Truly’s chemistry. We believed that by formulating with a clean and vegan base and combining with the most powerful, high performing skincare ingredients, Truly products would yield equal or better results than high-end or natural products,” reads the Truly site.

In addition to the Blueberry Kush, another collection — or shall we say strain — is called Pineapple Haze, which includes a CBD Glossy Lip Butter containing 50 milligrams of CBD as well as jojoba and vitamin E.

12. Therabody TheraOne CBD

We love the Theragun massage devices already, but did you know the same company makes CBD oils and ingestibles, too?

The oils and topicals are what we really want to call out, as they are a perfect compliment to a Theragun Mini or other massage device you have at home. Simply apply the oil or lotion to the area and massage away, letting the machine glide over sore muscles and the CBD seep into your skin.

The 24-7 Support CBD Bundle is a great starter kit, coming with a bottle of 100mg Sleep Tincture, a tube of 300mg Activate Lotion and an 835mg stick of Revive Balm to apply to sore muscles. All of the above are also sold separately, as are an array of other products to get you going, like massage oil and even sets that include Theragun devices.

13. Sagely Naturals

Take a walk on the natural side of life and see how you feel.

Sagely Naturals is a CBD wellness brand with that mission in mind, creating all of their topicals with non-GMO, sun-grown hemp and other goodies like turmeric, peppermint, lavender and more.

The site is designed to help you shop by collection if you need a good place to start, like Relief & Recovery, Rise & Well and Drift & Dream to name a few. Within those categories are shoppable products like skincare options, creams, roll-on oils and more, ranging in CBD concentration and the other natural ingredients listed above.

This site is also a hub for CBD knowledge, with a CBD 101 page to help consumers understand the process from beginning to end, along with the medicinal aspect of hemp and answering your most common questions.

14. Day One, take 15% off when signing up for their email list

Is today the day you start adding CBD to your life?

It is as easy as drinking water, with Day One. The beverage brand makes sparkling water with 20mg of CBD inside, along with real fruit and no added sweetener. Currently the lineup of flavors includes grapefruit, lemon and lime, which are all refreshing flavors for the upcoming summer.

The cans are sold in 12-packs, breaking down to $3 per can when you do the math. For those that love sparking water and need a constant supply, they also offer a subscription model with deliveries every two, four, or eight weeks. This lowers the normal price of $36 per box to $29 and eliminated the fear of running out.

To learn more, head to the brand’s About page, where you will also see an endorsement from rapper Kendrick Lamar, an FAQ page and more.

15. Joy Organics

If you get joy from trying new products, here is a CBD brand with great reviews.

Joy Organics is a CBD company that offers a full range of products, including oils, gummies, topicals and even pet products. Each include Broad and Full Spectrum CBD, now USDA Certified organic, to match the name.

Since they offer quite a bit, they have a handy quiz on the site to help you figure out where to start and which products to add to cart. Alternatively, if you know what you want, check out the bestsellers like their line of soft-gels capsules with options for 10mg or 25mg of CBD, as well as other blends with melatonin or curcumin.

16. Charlotte’s Web, take 20% off with code HEMPLOVE

This Charlotte’s Web tells the story of CBD, with chapters on oils, tinctures, gummies and more.

The popular CBD brand is named after a little girl, Charlotte Figi, who passed away after suffering from seizures and other health problems related to Dravet syndrome. She inspired the The Stanley brothers (cannabis farmers from Colorado) and the rest is history.

Now, the company has grown and expanded, offering a wide variety of products. Take the quiz to find out what is best for you, or start shopping the bestsellers like topicals, capsules and even CBD for dogs.