What cbd oil works for lack of enery and interest

Top 10 CBD Oils – Our Favorites for 2021

The CBD oil that works best for you should meet your needs for symptom relief, price point, and minimal side effects. It may even depend on your previous experience with marijuana and cannabis products. Since this is different for everyone, you may need to do your own research and try a couple different oils before you find the one you like best.

However, if you’re like us, you probably don’t want to break the bank testing out a variety of products. That’s why we’ve already done it for you. Below, we’ve picked the top 10 CBD oils currently on the market and evaluated them for a range of different uses. Whether you’re looking for an unflavored oil, broad-spectrum, or high potency, we’ve got you covered.

Keep in mind that CBD could be a great option toward holistic health and wellness, though there’s still much research to be done. Use our guide to help get started with CBD.

Top 10 CBD Oils

  • Best Potency – Spruce
  • Best Natural Ingredients – NuLeaf Naturals
  • Best By Reviews – MedTerra
  • Best For Beginners – Naternal
  • Best Natural Flavor – Cornbread Hemp
  • Best Without THC – Sunday Scaries
  • Best Full Spectrum – Populum
  • Best Organic Oil – Vital Plan Select
  • Best Low-Cost – Superfine
  • Best To Buy In Bulk – Mega Good Vibes
Our Favorite CBD Oil
Spruce 2,400mg Lab Grade CBD Oil

What is CBD Oil?

CBD oil or Cannabidiol is a natural molecule of cannabis, which comes from the hemp plant. It’s become popular in the media over the last couple of years, but it was discovered before THC in 1940. The chemist, Roger Adams, of Harvard University was the first person to extract CBD successfully, and scientists started to see the benefits of CBD in the 1960s.

Scientists Dr. Walter S. Loewe and Dr. Raphael Mechoulam took further steps to conduct a test to prove CBD doesn’t alter your mental state. They also identified the three-dimensional structure of the molecule.

CBD oil can be made from both hemp and marijuana, but there are some key difference between the two. Unlike marijuana, hemp plants are legal in the U.S. since the introduction of the 2018 Farm Bill which excluded it from the Controlled Substances Act, and therefore all hemp-derived products are legal. Another main difference between CBD oil derived from hemp versus CBD oil derived from marijuana is the cannabinoid content. Unlike marijuana, which contains between 5% and 30% THC, hemp plants legally cannot contain more than 0.3% of THC. As a result, hemp-derived CBD oil does not have THC’s intoxicating effect, allowing you to experience the benefits of CBD without the “high” associated with marijuana.

How is CBD Oil Produced?

What exactly does it mean when you see “hemp extract” on the label of CBD oil? CBD production starts with the process of extraction from the cannabis plant. Different extraction methods can be used for converting hemp into CBD products, but the quality of the extraction varies.

The CO2 process is the most common method for CBD oil and provides high-quality extraction. It is performed by heating CO2 and diffusing it throughout the hemp plant to pull the oil. Extraction then leads to the many methods of bottling and consumption, such as tinctures, vape juice, CBD oil-infused coffee and beer, gummies, massage oils, and pet treats.

You can ingest the oil by mixing it with other drinks and liquids or simply put a few drops on your tongue. Gummies are also extremely popular, and many people feed their pets CBD infused treats to help with anxiety and illnesses. Topical oils and lotions containing CBD may also alleviate sore muscles and joint aches. Users enjoy CBD oil as it may relieve pain, anxiety, inflammation, nausea, and seizures.

Why Should Seniors Use CBD?

CBD is increasingly popular for those who want to find natural relief for health conditions or who are looking to promote their overall wellness. In particular, seniors may find relief from the use of CBD oil as the potential benefits it offers align with conditions commonly experienced as we age. If you’re looking for a natural, plant-based product instead of pharmaceuticals, CBD may temporarily ease symptoms caused by digestive problems, muscle pains, and other conventional medical issues. Users report that CBD oil causes minimal side effects, is non-toxic, non-addictive, and there are currently no reported deaths or overdoses linked to CBD. CBD oil may be an excellent alternative to some medications as it is cost-effective, easy to use, and eco-friendly.

How to Start Using CBD

While the FDA is working to answer questions about the science, safety, and quality of CBD products, there are no regulatory guidelines in place just yet. However, the medical community is more commonly suggesting CBD as a potential option for the relief of temporary symptoms. While CBD can deliver a variety of health benefits, we advise consulting your doctor before taking CBD. Your current health conditions and any prescription medications should be considerations, as adverse CBD drug interactions can be a concern. It is known to increase the effects of some drugs, including blood thinner or over-the-counter medication, which has the risk of blood-thinning like ibuprofen. Your doctor can help identify if it is safe for you to take CBD or suggest a precise dose that won’t be harmful.

Determining what dose of CBD oil to take includes looking at many factors, including your body’s chemistry and BMI. You should always consult your medical provider to assess accurately how much of the product you should take. It is also smart to start at a lower dose and slowly increase your daily use. Before beginning to use CBD, you should consider the quality of a CBD product based on organic growing techniques, extraction method, mg per dose, full-spectrum offerings, flavors, and reviews reporting effectiveness.

Top 10 CBD Oils for Seniors

There are many CBD oils out there these days, so we’ve narrowed it down to 10 great options to kickstart your entry into the CBD world. We compared CBD oils based on how they utilized, price, dosage, size, and top features. We also considered the diet’s it may be best suited for and unique qualities. By collecting customer reviews and research, we’ve got you covered on the best CBD products available.

Best Potency

Spruce

Price:
Dosage:

25 mg / 80 mg per dropper

Top Features:
  • Family owned business
  • Unique moonshine extraction method
  • Organic
  • Vegan and gluten-free
  • Offer an “extra strength” potency

Spruce offers lab-grade CBD in the form of oils and cream. They offer a competitive price with 2,400 mg of oil at $269, and 750mg oil tinctures for both humans and dogs at $89. They also offer a subscribe and save option for all products that will give you a 15% discount and free shipping. Spruce offers one of the best options in dosage and price comparison, and customers agree that it’s hard to beat their potency. Learn more about Spruce’s CBD oils in our full review.

Best Natural Ingredients

NuLeaf Naturals

Price:
Dosage:

5 mL, 15 mL, 30 mL, 50 mL,
and 100 mL

Top Features:
  • Derived by CO2 extraction
  • Organic
  • Made without additives or preservatives
  • Fast and free shipping
  • Third-party lab tested

NuLeaf Naturals offers CBD oil in its most pure and simple form. The company features a variety of bottle sizes making it easy to find your optimal dosage, whether you use CBD every day or just when you need it the most. Each bottle contains CBD oil that is free of additives, preservatives, herbicides, pesticides, and fertilizers. When using NuLeaf Naturals CBD oil, drop your preferred dose under your tongue and hold it before swallowing. Many customer reviews celebrate the product’s effectiveness for minor pain, such as shoulder and backaches.

Best By Reviews

MedTerra

Price:
Dosage:

50 mg, 1000 mg or 3000 mg per bottle

Top Features:
  • US Hemp Authority Certified
  • Ship to all 50 states and internationally
  • 30-day money-back guarantee
  • Non-GMO and organic
  • 10% discount when you subscribe

MedTerra offers CBD tinctures that combine 99% CBD and MCT oil in one-ounce bottles. They offer 500 mg, 1000 mg, and 3000 mg per dropper, and the tinctures have measurement markers to allow for accuracy and flexibility in servings. The average customer reviews for MedTerra are the best based on price, effectiveness, and speediness in delivery.

Best for Beginners

Naternal

Price:
Dosage:

20 mg – 80 mg per serving

Top Features:
  • Combines CBD with MCT oil
  • Published lab results online
  • Proprietary True Dosing System to help guide beginners
  • Testimonials about reduced anxiety, depression, and insomnia
  • Contains less than 0.3% THC

Naternal is a Hemp company with a desire to help newcomers access the benefits of CBD. The company has developed a proprietary True Dosing System and online guide that can help you customize your dose regardless of which Naternal product you choose. The company uses 20 mg as its foundation for dosing, which is usually the standard minimum dose recommended for most adults. Their Full Spectrum Help Extract Oil is available in 20 mg, 40 mg, and 80 mg servings.

Best Natural Flavor

Cornbread Hemp

Price:
Dosage:

25 mg per serving

Top Features:
  • Distilled to 75% purity
  • Quick absorption
  • Natural flavor
  • Kentucky-grown hemp
  • 30-day satisfaction guarantee

Cornbread Hemp gets its name from Kentucky hemp farmers who grew the plant as far back as 1775, even before it was legal. Now that hemp and CBD are legal nationwide, Cornbread Hemp is dedicated to using the highest-quality Kentucky hemp to provide a variety of wellness products to its customers. The Original CBD Oil offers CO2 extracted CBD that’s distilled to 75% purity. For best results, take Cornbread Hemp CBD Oil daily directly in your mouth or mixed in with a beverage. Customer reviews especially liked its effects on sleep, anxiety, and chronic pain.

Best Without THC

Sunday Scaries

Price:
Dosage:

10 mg per serving

Top Features:
  • Contains coconut oil and organic stevia
  • Contains vitamins D3 and B12
  • Broad spectrum, meaning no THC
  • Subscription savings
  • Hemp sourced from Colorado

True to its name, Sunday Scaries CBD Oil helps eliminate some of life’s common everyday anxieties. The company says their CBD can help with sleep, calming your mind at night, relieving flight anxiety, and enhancing your meditation. Though these claims have not been evaluated by the FDA, customer reviews do say they’re happy with the oil and its effects after everyday use. The oil is broad spectrum, meaning it contains absolutely no THC. While most oils still contain trace amounts, this option could be best if you’d like to avoid THC altogether. This oil is also designed to be better tasting and packed with essential vitamins that may help regulate your nervous system and even boost your immune system. To use, start with 1/3 of a dropper. You should feel effects within 20 to 30 minutes after ingestion.

Best Full Spectrum

Populum

Price:
Dosage:

8 mg – 33 mg per serving

Top Features:
  • Ethically sourced hemp from Colorado
  • Award-winning orange flavor
  • Non-GMO and gluten-free
  • 30-Day risk-free trial
  • Step-by-step instructions available online

Populum offers a Full Spectrum CBD Oil with more than 500 excellent customer reviews. Populum sets itself apart with a dedication to the customer experience, from purchasing the bottle to using it for the first time and coming back for more. Customers say they enjoy the unique, mild orange flavor, and the oil has helped them get a full night’s sleep and feel overall better throughout day to day activities. If you’re just getting started, Populum recommends starting with the 8mg dose each day, and even offers a video tutorial of how you can successfully take your CBD tincture.

With a full-spectrum CBD oil, this means that the product you get undergoes minimal processing. Using an extract method like CO2 extraction, CBD and more cannabinoids are drawn out of the hemp plant. These products do contain very nominal amounts of THC. Some companies and studies assert that the additional cannabinoids in full-spectrum products help to boost CBD’s effects.

Best Organic Oil

Vital Plan Select

Price:
Dosage:

20 mg – 40 mg per serving

Top Features:
  • Certified organic green cherry hemp
  • Full-spectrum with terpenes and organic compounds
  • Contains MCT oil and peppermint extract
  • Peanut, egg, and dairy free
  • Contains less than .3% THC

Vital Plan Select offers a USDA-certified organic CBD oil that’s sourced from Colorado-grown hemp. Vital Plan Select is dedicated to providing customers with the safest CBD experience possible, ensuring their product is safe for vegetarians, those with Celiac Disease, and anyone with common peanut, egg, or dairy allergies. The Vital Plan Select oil is full spectrum, meaning it contains trace amounts of THC along with additional cannabinoids and hemp compounds, including terpenes. This product has up to 6 times more terpenes than most other CBD oils on the market, which could help enhance the effects of CBD.

Best Low-Cost

Superfine

Price:
Dosage:

250 mg – 750 mg per bottle

Top Features:
  • Free or preservatives and pesticides
  • Vegan, organic, and gluten-free
  • Processed in FDA-registered facility
  • Third-party lab results immediately available
  • 30-day satisfaction guarantee

Superfine offers one of the most budget-friendly options for CBD lovers and beginners alike. Their Organic CBD Oil has a starting price of $38. Furthermore, you can cut your cost to $30.40 by opting for a monthly subscription. Superfine CBD Oil is easy to use with a marked dropper that ensures you’re taking the correct dose. Simply drop the oil under your tongue and hold it for one minute before swallowing. You can take the CBD oil twice per day and split your dose in the morning and night for best results.

Best to Buy in Bulk

Mega Good Vibes

Price:

$174.99-$199.95 per bottle

Dosage:

2500 mg per bottle

Top Features:
  • Organically grown hemp
  • Contains MCT oil and peppermint oil
  • 30-day satisfaction guarantee
  • Colorado-grown hemp
  • Triple-tested hemp

Mega Good Vibes offers a pure hemp extract CBD oil that includes MCT coconut oil and peppermint oil for flavor. The company offers a unique offering of 2-packs, 3-packs, and 6-packs, so you can buy a single bottle or buy in bulk. When you first purchase a bottle, you get a 30-day satisfaction guarantee so you can determine if it’s the right product before purchasing again. Overall, the bulk options will offer cost savings if you know you enjoy the CBD oil for everyday use. To use Mega Good Vibes, you can take 1-3 servings per day depending on your unique dose and needs. The company does recommend starting with one full dropper before increasing your dose from there. Customers say they enjoy the oil to help relieve stress throughout the day and to sleep better at night.

What are the Potential Benefits of CBD?

The properties of CBD have the potential to provide health benefits for a wide range of conditions, as increasingly evident by scientific research. For many, CBD may improve quality of sleep and temporarily relieve insomnia. Studies have also shown it can help alleviate pain and inflammation frequently caused by arthritis and joint pain. More recent research suggests that CBD may improve heart health. A 2017 study determined CBD can reduce blood pressure and may also have therapeutic potential for treating cardiovascular disorders by reducing cardiac inflammation. There is also promising research that CBD may help preserve bone density and promote bone fracture healing, which both can be issues of concern for many seniors.

Potential Benefits of CBD:

Common FAQs

Is CBD safe for seniors?

CBD may have many benefits for seniors, but it’s essential to consult with your doctor before giving CBD a try. Your current prescriptions and medications may react with CBD products, so your doctor can recommend replacing CBD with some medications or advise on the correct dosage for your specific needs.

Does CBD oil have side effects?

Side effects of CBD are rare but could include dry mouth, nausea, diarrhea, and changes in appetite. If you’re taking other medications, CBD can affect the way the liver breaks down those medications causing an adverse reaction. CBD has also been linked to temporarily lowering blood pressure.

Can I buy CBD oil online?

CBD oil has increasingly become more available online, with numerous retailers across the world shipping CBD right to your doorstep. It helps to do your research and compare products based on potency, flavors, price, size, extraction, broad vs. full-spectrum, how you consume the CBD, dietary restrictions, and other factors. There are many CBD options for you to try out as you begin your journey.

Tips for Purchasing CBD Oils

CBD Oil Choices

Because there are so many CBD products available, it is first helpful to know there are three major categories to choose from, each with different characteristics: CBD Isolate, Full Spectrum CBD, and Broad Spectrum CBD. Although products may differ, they all deliver CBD inside a carrier oil, and these categories will indicate which type of cannabinoid your product contains.

CBD Isolate

As with CBD Isolate, there is no significant level of THC in Full Spectrum CBD though it’s not completely removed. Unlike CBD Isolate, the additional compounds found within the cannabis plant are preserved, offering the potential for a broader range of therapeutic benefits and a higher level of relief comparatively.

Full Spectrum CBD

As with CBD Isolate, there is no significant level of THC in Full Spectrum CBD though it’s not completely removed. Unlike CBD Isolate, the additional compounds found within the cannabis plant are preserved, offering the potential for a broader range of therapeutic benefits and a higher level of relief comparatively.

Broad Spectrum CBD

Broad Spectrum CBD is similar to Full Spectrum in that it contains a variety of cannabinoids for added Benefit, but it has zero THC. Though there is less research available for Broad Spectrum CBD, it may be the right choice if you are sensitive to THC or have a condition not alleviated by Isolate CBD that may benefit from the enhanced effect of multiple cannabinoids.

CBD Oil vs. Hemp Seed Oil vs. Full Spectrum Hemp Oil

CBD oil, hemp seed oil, and full-spectrum hemp oil all have potential health benefits that interest consumers. It is essential to know, however, that they are very different products. Here we will help you understand the differences and how to choose which one may be the safest and most appropriate for your needs.

CBD oil utilizes the highly concentrated CBD found in flowers, stalks, and leaves of the hemp plant. Hemp plants produce a variety of cannabinoids with numerous potential medicinal benefits from relieving pain and inflammation to treating epilepsy. It can be ingested or used topically.

Hemp seed oil is derived from the seeds of the Cannabis sativa plant. These seeds are nutrient-rich but do not contain CBD. Hemp seed oil offers many healthful benefits and can be used in a variety of ways. It is packed with essential fatty acids and amino acids and often taken a supplement to support cardiovascular health, promote brain function, and for its possible antioxidant and anti-aging effects. It is commonly found as a capsule or tincture or used topically for skincare.

Full-spectrum hemp oil refers to the oil produced from the entire Cannabis sativa plant, not just the seeds. Full-spectrum hemp oil that also contains plant matter has a higher concentration of other additional compounds that may offer more benefits when used for issues such as inflammation and muscle tension. It can be found in different forms, including capsules, balms, tinctures, and more.

CBD in the News

CBD is undoubtedly gaining traction. The shifting and growing market see an increase in online purchasing and an increase in the types of CBD products used. The CBD oil market is expected to grow by almost 32% by 2027. With CBD products becoming more accessible and affordable, companies are also becoming aware of the pressure of getting the U.S. Food and Drug Administration’s approval.

Seniors are increasingly looking towards CBD for treating aches and pains, but it can be challenging to find safe products while the market isn’t regulated. While the FDA is still developing regulations that could allow CBD to be marketed as a food item or dietary supplement, it published draft guidelines on cannabis research for drug manufacturing in July 2020, a sign that some progress is happening.

Conclusion

CBD oil has seen a considerable increase in popularity over the last several years, becoming a mainstream product in many countries. The CBD industry seems here to stay, and ongoing studies continue to provide evidence supporting some of the many potential health benefits of CBD.

It is important to remember, however, that CBD still needs more thorough research and is still largely unregulated. It is best to let your doctor advise on how CBD can work for you. Seniors should certainly take note of the risks, but CBD could be a viable option if you’re looking for natural relief for pains, anxiety, and restlessness. Luckily, there are plenty of resources to be found if you’re interested in exploring what CBD has to offer.

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CBD Oil for Chronic Fatigue Syndrome

Adrienne Dellwo is an experienced journalist who was diagnosed with fibromyalgia and has written extensively on the topic.

Verywell Health articles are reviewed by board-certified physicians and healthcare professionals. These medical reviewers confirm the content is thorough and accurate, reflecting the latest evidence-based research. Content is reviewed before publication and upon substantial updates. Learn more.

Meredith Bull, ND, is a licensed naturopathic doctor with a private practice in Los Angeles, California.

Chronic fatigue syndrome (CFS or ME/CFS) is an extremely difficult illness to treat. It features dozens of symptoms believed to stem from the dysregulation of multiple systems throughout the body. Cannabidiol (CBD) oil is a hot, up-and-coming treatment right now that’s being touted as a fix for all kinds of diseases. It’s only natural that a lot of people with ME/CFS would develop an interest in CBD oil as a possible treatment.

But is CBD a safe and effective treatment for this complex and debilitating disease? Thus far, we have no specific research on CBD for ME/CFS, so it’s too early to have an answer to that question.

Another possible deterrent for people considering this treatment is that CBD oil—which comes from hemp—gets wrapped up in the controversy over medical marijuana. That may make some people hesitant to try it. Additionally, it’s been hard to find a straight answer about whether it’s legal, but that concern should be going away soon.

Nusha Ashjaee / Verywell

What Is CBD Oil?

CBD stands for “cannabidiol,” which comes from the cannabis plant. That’s the same plant that gives us marijuana. However, CBD—as an oil or in other forms—doesn’t have psychoactive properties. That means it doesn’t provide the “high” associated with marijuana.  

The substance in marijuana that gets you high is called THC (tetrahydrocannabinol).   Growers who want to maximize the plant’s psychoactive effect use breeds and techniques that result in higher levels of THC. On the other hand, cannabis that’s grown for hemp is generally richer in CBD than THC, and that’s where CBD comes from.

CBD oil can be used in several different ways. You can smoke it (typically in vape pens), take it in capsule form, use it sublingually (under the tongue), use oral sprays or drops, or apply it topically to your skin. A crystalline form of pure CBD is also available, which is generally taken sublingually.

CBD products that are extracted from cannabis are being used for a lot of medical purposes, and you can find many claims online about miraculous results.

But are these claims true? And would it work as well for you? From a scientific standpoint, the answers are more like “we don’t know” and “possibly” and “some claims appear to be true” than a firm “yes,” and it depends on which claims you’re looking at.

People are using CBD oil for a whole lot of different medical purposes, including:

  • Chronic pain and inflammation, including neuroinflammation (a suspected feature of ME/CFS)
  • Social anxiety disorder
  • Halting the growth of cancerous tumors
  • The pain of glaucoma , especially in children
  • Bipolar disorder
  • Schizophrenia
  • Movement problems caused by Huntington’s disease
  • Help with smoking cessation

As of June 25, 2018, CBD oil has been approved by the U.S. FDA as an oral solution (Epidiolex) for the treatment of seizures associated with two very severe forms of epilepsy that usually affect children: Lennox-Gaustaut and Dravet syndromes.  

Research in the United States for other diseases is still in the early stages. That’s because legal restrictions have for decades made it extremely difficult to study the medical benefits of marijuana or any of its components, which are called cannabinoids. Promising research is being done, though, on multiple conditions. Down the road, it’s likely that we’ll eventually see many applications submitted to the FDA.

CBD Research and ME/CFS

Anyone who’s studied ME/CFS for very long will not be shocked to hear that, so far, we don’t have any research done on CBD oil as a treatment for this disease. That doesn’t mean we don’t know anything, though.

CBD is being researched for numerous conditions, and many of those conditions share features with ME/CFS. While we can’t say for certain that those results apply to similar conditions, they provide some basis for informed speculation.

Also, we’re likely to see CBD investigated for ME/CFS before long, for several reasons.

First, we just don’t have good treatments for ME/CFS. In fact, none are FDA approved. And while dozens of different medications and other interventions are used to help lessen the symptoms, many of them are only marginally effective and only help a fraction of those with the condition. Side effects tend to be a problem for this group, as well.

Second, we have a pain epidemic in the U.S. While not all ME/CFS involves pain, many cases do. Current treatments are inadequate, though, so there’s a big financial incentive to find something that’s better at relieving ME/CFS pain.

Third, we’re currently struggling with an opioid addiction and overdose epidemic in the U.S. Several studies have shown that when a state legalizes marijuana, either medicinally or recreationally, the number of opioid prescriptions drops. That’s good news for healthcare providers looking for safer pain treatments, for law enforcement agencies struggling to control the tide of illegal use, and for lawmakers trying to find solutions.

Fourth, CBD oil is believed to be effective against pain and inflammation, and, in its pure form, it’s generally regarded as safe. Especially in light of the theory that ME/CFS is related to neuroinflammation, and the wealth of evidence pointing to it being an inflammatory disease, it’s pretty obvious that there’s a potential benefit that should be explored.

Finally, while anecdotal evidence isn’t proof of anything, we already have an abundance of it from people with ME/CFS. When patients with difficult-to-treat conditions tell their healthcare providers something works, you can bet it gets them interested.

A 2017 ​paper published in Expert Opinion on Therapeutic Targets suggested CBD as a possible way to diminish the activity of brain cells called glia that can lead to central sensitization. That’s a hypersensitive central nervous system and a major feature of ME/CFS and other central sensitivity syndromes such as fibromyalgia, irritable bowel syndrome, and migraine.

CBD is believed to help with your body’s homeostasis, which is keeping things like temperature, respiration, and blood flow in proper balance. Homeostasis tends to be out of balance in ME/CFS.

While it’s less well documented in ME/CFS, a condition called endocannabinoids deficiency, characterized by lower amounts of naturally produced endocannabinoids in certain individuals, has been linked to fibromyalgia, making cannabis products a promising treatment.

A 2016 review published in Cannabis and Cannabinoid Research found evidence that CBD is effective in treating migraine and irritable bowel syndrome, which are related to ME/CFS. It also stated that some cannabis-based treatments appeared effective for fibromyalgia. The authors stated that CBD is often preferable to patients because it doesn’t include the high and other effects of THC.

As mentioned earlier, several studies have suggested that CBD can fight inflammation. That’s a big deal for a disease that research links to chronic inflammation, and possibly to neuroinflammation as an underlying cause.

A 2017 French study on Alzheimer’s disease suggests that CBD lessens oxidative stress, diminishes mitochondrial dysfunction, and suppresses pro-inflammatory activity. All of those things could prove helpful against known and suspected dysfunctions associated with ME/CFS.

A 2011 study out of Italy suggested that CBD may lower intestinal inflammation via control of the neuro-immune axis. While that study was on inflammatory bowel disease, changes to the neuro-immune axis could be beneficial in ME/CFS, as well.

Side Effects

We don’t have a full picture of the possible side effects of CBD. Some reported side effects include:  

  • Changes to liver enzymes used to process drugs
  • Dry mouth
  • Low blood pressure
  • Lightheadedness
  • Drowsiness
  • Increased tremor in Parkinson’s disease, at high doses

The following effects are possible but require more study, according to the World Health Organization:

  • Alteration of hormonal levels
  • Immune system stimulation at low levels, and immune suppression at higher levels

The immune system effects will be especially important for ME/CFS, which is believed to involve a chronically overactive immune system.

Addiction and abuse don’t appear to be problems with CBD, and it appears to have a low toxicity level, which means that it takes a lot to overdose.

Is It Legal?

When the 2018 Farm Bill was signed into law, it made hemp an agricultural product. That means products made from hemp—including CBD—are legal at the federal level.

However, some states and municipalities have passed laws specifically banning hemp products or CBD. Technically, federal law overrides state law. That doesn’t mean, though, that your state or town will automatically stop making arrests and pressing charges under its CBD laws.

If you’re in an area with laws prohibiting CBD, you may want to consult a legal expert on whether it could be a problem for you. Better safe than sorry.

The website ProCon.org has information about which states have laws specific to CBD oil. A site called Governing maintains a map of where marijuana is legal in some form.

A Word from Verywell

You have a lot to consider when it comes to any form of treatment, and even more when it comes to CBD. Be sure to consider the pros and cons, including the legal ones. Discuss this option with your healthcare provider to make sure you’re not endangering your health. As with any treatment, watch for side effects.

With legal changes in-store and more research coming, things may change rapidly when it comes to CBD oil and other cannabis-based treatments. It’s likely that we’ll know a great deal more about the effectiveness and safety of these products a few years from now.

Chronic Fatigue Syndrome Doctor Discussion Guide

Get our printable guide for your next doctor’s appointment to help you ask the right questions.

Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.

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Nagarkatti P, Pandey R, Rieder SA, Hegde VL, Nagarkatti M. Cannabinoids as novel anti-inflammatory drugs. Future Med Chem. 2009;1(7):1333-49. doi:10.4155/fmc.09.93

Burstein SH, Zurier RB. Cannabinoids, endocannabinoids, and related analogs in inflammation. The AAPS Journal. 2009 Mar;11(1):109-19. DOI: 10.1208/s12248-009-9084-5.

De Filippis D, Esposito G, Cirillo C, et al. Cannabidiol reduces intestinal inflammation through the control of neuroimmune axis. PLoS One. 2011;6(12):e28159. DOI: 10.1371/journal.pone.0028159.

Hill KP, Saxon AJ. The role of cannabis legalization in the opioid crisis. JAMA internal medicine. 2018 May 1;178(5):679-680. DOI: 10.1001/jamainternmed.2018.0254.

Nijs J, Loggia ML, Polli A, et al. Sleep disturbances and severe stress as glial activators: key targets for treating central sensitization in chronic pain patients? Expert opinion on therapeutic targets. 2017 Aug;21(8):817-826. DOI: 10.1080/14728222.2017.1353603.

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