Cannabis Oil Not Wise for Skin Cancer
A patient recently asked if Cannabis oil might be used to cure a small skin cancer.
Never having been asked this before, a thorough review of the available literature was carried out, but sadly there have been absolutely no published clinical trials to date so it is impossible to recommend this treatment.
Cannabinoids do bind to receptors which are present in many cells and there is some evidence in highly controlled laboratory circumstances that cannabinoids may inhibit some cancers. Sadly, there is also evidence that it may actually accelerate growth in others. There have been no useful trials in living humans and animal trials are not conclusive. The link at the end of this article gives more information and is maintained by the Uk Cancer Society so may be seen as a trusted and valid reference.
The proposed mechanisms of action of cannabis oil are plausible but unfortunately that does not make it safe or effective.
A search of the internet lists many sites where people claim to have had skin cancers cured by cannabis oil. This effect may occur for one of the following reasons:
- It is possible that the cannabis oil actually removed the cancer (a small proportion probably do get better as a result of treatment)
- The act of rubbing itself can stimulate immune reactions which can deal with some skin cancers.
- Some skin cancers will naturally go away on their own.
- The skin cancer may actually have been something else entirely (misdiagnosis of these lesions is common)
It is important to note that some of the cancers being illustrated as treated with the oil are of a type that can spread and potentially kill the patient. We feel that using a totally untrialled medication like cannabis oil in such circumstances is very unwise.
Cannabis oil is of course illegal in New Zealand so as a treatment option it is not valid in any case. Hemp oil contains cannabinoids but the concentration is much lower.
The good news is that not all skin cancers need surgery – some may be suitable for treatment with cream, especially in older patients and in many cases, the treatment is fully funded.
If you think you may have a skin cancer, please make an appointment – our doctors are very good at skin diagnoses and can give you proper treatment advice from leaving harmless things alone through creams to surgical removal if required.
We feel that it is important to point out that there is also good evidence that smoking cannabis (as opposed to a topical application) significantly increases the risk of lung and head and neck cancer, whether or not it is used in combination with tobacco. Whilst there may in the future be a place for medicinal use of cannabinoids, at present the evidence very strongly suggests that in almost all cases the side effects outweigh the benefits.
Addendum September 2016:
We have been asked to provide evidence to support the statement that cannabis smoking causes cancer. The spectrum of carcinogens in cannabis smoke is similar to that in tobacco smoke. It is the inhaling of burned leaves that results in tar deposition in the lungs. Cannabis smoke is generally retained in the lungs for longer than tobacco smoke which may also explain how cannabis causes chronic obstructive pulmonary disease. In a New Zealand study in 2008, it was found that cannabis smoking was associated with similar, or higher rate of lung cancer than tobacco smoking. Cannabis has also been associated with testicular cancer. Recent evidence casts doubt on the assertion that head and neck cancers are caused by cannabis smoking though it is important to note that the development of head and neck cancer is very slow and often occurs in association with other risk-factors. Some studies have shown an association and some have not. It remains our advice that the smoking of any substance is profoundly unwise and there is no reason to believe that cannabis is any safer than tobacco.
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CBD for Skin Cancer
Just hearing the word “cancer” can be alarming—and receiving a diagnosis even more so. While skin cancer is more easily spotted and treatable than other types of cancer, it’s still just as frightening when one is diagnosed with it. After all, our skin is our first impression to the world.
Skin cancer is the most common cancer in the U.S., and is a broad term describing an abnormal growth of cells that has the ability to spread. The areas of the body most commonly affected are those that are exposed to the sun, but skin cancer can develop anywhere on the body.
How do most people get skin cancer? Sun exposure—more specifically, exposure to UVB radiation. This type of radiation comes from not only the sun but also sunlamps and tanning booths. Avoiding exposure to UVB radiation and using sunscreen when you are outdoors may help prevent some skin cancers from forming.
Most skin cancers—with the exception of melanomas—do not spread very quickly, if at all, and many can be successfully treated with surgical procedure called excision.
Table of Contents
- Types of Skin Cancer
- Animal Studies
- Human Studies
- Additional CBD Resources on Cancer
Types of Skin Cancer
There are different types of skin cancer. These include:
- Non-Melanoma Skin Cancer
- Basal cell carcinoma: Basal cells produce new skin cells, and basal cell carcinomas usually occur on sun-exposed skin and may look like a shiny almost translucent or pearly bump on the skin. But they can also be dark brown, black, or a dark bluish color. Sometimes they are a reddish scaly patch of skin. These types of cancers tend not to spread.
- Squamous cell carcinoma: Squamous cells make up the middle and outer layers of skin. This type of cancer also appears on skin exposed to sunlight, and it can manifest in different appearances on different parts of your body. This type of cancer can be aggressive, but it also isn’t prone to spreading. Squamous cell carcinoma can look like a nodule (often red), a crusty area on the skin, or a reddened area in the mouth, the anus, and around the genital area.
- Rarer types include angiosarcomas, cutaneous lymphomas, and others
- Melanoma is the most dangerous form of skin cancer. It develops in the pigment cells of the skin—the cells that produce melanin.
- Melanoma can also metastasize, or spread, to other areas of the body. It is metastasis that makes this cancer—and all types of cancers—so dangerous.
One of the obstacles in catching skin cancer early is that normal skin blemishes, such as moles, are often overlooked for long periods of time as being nothing to worry about. To help distinguish everyday moles from possible melanomas, use the mnemonic “ABCDE.”
- Asymmetric in shape
- Borders are irregular
- Changes in color
- Diameter over ~¼ inch (6 mm)
- Evolving changes—changes that can include shape, color, size or if a mole begins to bleed or itch
CBD and Skin Cancer
Any cell can be transformed into a cancer cell—and there are many, many ways this can happen depending on the specific cell. This is just one of the reasons there may never be a single “cure” for cancer in general; cancer represents well over 100 different types. Each type of cancer may have different mechanisms contributing to its transformation and each may have different points at which it can be treated.
Underlying all cancers is the regulation of gene expression. For every type of cancer, there is a different gene (or genes) that becomes activated or deactivated causing the cell to become cancerous.
The functions of the endocannabinoid system—the natural biological system that “overlaps” with plant-derived cannabinoids—include inhibiting tumor cell replication and growth, inhibiting the spread of a tumor (metastasis) partly by inhibiting the growth of new blood vessels, and inducing a form of cell death known as apoptosis.
Some studies have indicated that poorly functioning endocannabinoid system may set the stage for conditions that allow the cancer cells to proliferate and metastasize. Note the subtle difference between a poorly functioning endocannabinoid system causing the initial transformation of cells into cancer cells and allowing cancer to progress. Think of it as the difference between a water tap where no water flows out at all and a water tap that allows a few drops of water to flow.
In mice, for example, cannabinoids have been shown to reduce the size of breast tumors and lower the frequency of metastasis. Many other studies have indicated that the endocannabinoid system is functional in the skin and may play a role in skin cancers, especially inflammatory skin cancers.
Animal models have revealed some paradoxical findings—in other words, cannabinoids have been found, under different conditions, to be both supporting cancer cells and inhibiting cancer cells. This is true for both melanoma and nonmelanoma, and may be dose dependent.
You probably guessed it—there are very studies on CBD for skin cancer in progress at the moment. For now, though, we have some limited data from studies performed in human cells cultures—but these studies used synthetic cannabinoids and not CBD.
Summary of the Use of CBD for Skin Cancer
Currently, there are only theories why CBD for skin cancer might inhibit cancerous cell growth: In particular, CBD’s anti-inflammatory properties (cancer and inflammation go hand-in-hand) and its ability to inhibit the growth of the blood vessels needed to “feed” a tumor. There may also be some more direct effects of cannabinoids on tumor growth and on inducing apoptosis.
All this taken together shows promise that CBD for skin cancer could play part in future treatment protocols, but more clinical trials and more information are still needed.
Most of the common skin cancers like squamous and basal cell carcinomas are relatively noninvasive and, if caught early, can be completely removed by excision. The more invasive melanoma form of skin cancer is harder to detect and requires a more extensive treatment protocol including surgery, radiation treatment, and chemotherapy. Early melanoma has a survival rate of 98 percent—but this falls to 23 percent if the melanoma spreads to other parts of the body.
Early detection is key. This is why if you suspect that a mole on your body has changed, or you have found a new scaly patch on your skin, or you are just not certain if that spot on your skin has always looked like that or not—go see a qualified dermatologist, and follow their treatment advice. If you receive a cancer diagnosis, don’t be afraid to ask your doctor about CBD for skin cancer. Ask them if they know about any new research.